The effects of metformin, donepezil, insulin glargine, and glibenclamide on serum biomarkers: Glucose, HbA1c, lipid profile, IL6, TNFa, amyloid β 42, total plasma tau, and NFL. by Shatw Khalid Ali (13020885)

Effect of ELX-02 in <i>CTNS</i>^{<i>Y226X/Y226X</i>} mice. by Emma J. Brasell (8081969)

“…<p><b>A</b>. Half-cystine measurements show decrease pathologic accumulation in kidneys of <i>Ctns</i>^{<i>Y226X/Y226X</i>} mice treated with 7 injections of ELX-02 (10 mg/kg) over a 3-week period. …”

Image_2_The P2X7 Receptor 489C>T Gain of Function Polymorphism Favors HHV-6A Infection and Associates With Female Idiopathic Infertility.tif by Anna Pegoraro (8213589)

“…We show that functional P2X7R increases while its blockade decreases viral load. …”

CTNS protein and mRNA levels in human fibroblasts. by Emma J. Brasell (8081969)

Analysis of (-)-epigallocatechin gallate (2.5 mmol/L) upon titration with salivary mucin. by Judith Delius (3813784)

The productivity of a research unit as a function of the funding <i>x</i>. by Miguel Navascués (164739)

Validation of NUMB as a target for <i>miR-146a</i>. by Pei-Shi Hung (489732)

Lead Optimization of Androgen Receptor-HSP27 Disrupting Agents in Glioblastoma by Yaxin Li (312731)

“…Compounds <b>4</b> and <b>6</b> exhibit IC₅₀s of 35 and 23 nM, respectively, to inhibit cell proliferation and also show significant activity to decrease the tumor growth <i>in vivo</i>.…”

Image_1_Extracellular Vesicles Carry lncRNA SNHG16 to Promote Metastasis of Breast Cancer Cells via the miR-892b/PPAPDC1A Axis.TIFF by Wenfei Xia (5055482)

Anti-inflammatory Meroterpenoids from <i>Baeckea frutescens</i> by Ji-Qin Hou (3642946)

“…Compound <b>8</b> exhibited anti-inflammatory activity with an IC₅₀ value of 0.36 μM, which might be related to the regulation of the NF-κB signaling pathway via the suppression of p65 nuclear translocation and the consequent decrease of IL-6 and TNF-α.…”

Anti-inflammatory Meroterpenoids from <i>Baeckea frutescens</i> by Ji-Qin Hou (3642946)

“…Compound <b>8</b> exhibited anti-inflammatory activity with an IC₅₀ value of 0.36 μM, which might be related to the regulation of the NF-κB signaling pathway via the suppression of p65 nuclear translocation and the consequent decrease of IL-6 and TNF-α.…”

Anti-inflammatory Meroterpenoids from <i>Baeckea frutescens</i> by Ji-Qin Hou (3642946)

“…Compound <b>8</b> exhibited anti-inflammatory activity with an IC₅₀ value of 0.36 μM, which might be related to the regulation of the NF-κB signaling pathway via the suppression of p65 nuclear translocation and the consequent decrease of IL-6 and TNF-α.…”

High blood glucose levels in rats after exposure to STZ. by Shatw Khalid Ali (13020885)

Enantiomeric Deoxycholic Acid:  Total Synthesis, Characterization, and Preliminary Toxicity toward Colon Cancer Cell Lines by Bryson W. Katona (2465581)

“…To further explore DCA induced changes in cell signaling, we completed a total synthesis of enantiomeric deoxycholic acid (<i>ent</i>-DCA) from achiral 2-methyl-1,3-cyclopentanedione. Using a modified method of the synthesis of <i>ent</i>-testosterone that proceeds through the (<i>R</i>)-(−)-Hajos−Parrish ketone, we have completed the successful synthesis of <i>ent</i>-DCA in 25 steps with a yield of 0.3% with all stereochemical assignments of the product confirmed by X-ray crystallography. …”

Enantiomeric Deoxycholic Acid:  Total Synthesis, Characterization, and Preliminary Toxicity toward Colon Cancer Cell Lines by Bryson W. Katona (2465581)

“…To further explore DCA induced changes in cell signaling, we completed a total synthesis of enantiomeric deoxycholic acid (<i>ent</i>-DCA) from achiral 2-methyl-1,3-cyclopentanedione. Using a modified method of the synthesis of <i>ent</i>-testosterone that proceeds through the (<i>R</i>)-(−)-Hajos−Parrish ketone, we have completed the successful synthesis of <i>ent</i>-DCA in 25 steps with a yield of 0.3% with all stereochemical assignments of the product confirmed by X-ray crystallography. …”

Enantiomeric Deoxycholic Acid:  Total Synthesis, Characterization, and Preliminary Toxicity toward Colon Cancer Cell Lines by Bryson W. Katona (2465581)

“…To further explore DCA induced changes in cell signaling, we completed a total synthesis of enantiomeric deoxycholic acid (<i>ent</i>-DCA) from achiral 2-methyl-1,3-cyclopentanedione. Using a modified method of the synthesis of <i>ent</i>-testosterone that proceeds through the (<i>R</i>)-(−)-Hajos−Parrish ketone, we have completed the successful synthesis of <i>ent</i>-DCA in 25 steps with a yield of 0.3% with all stereochemical assignments of the product confirmed by X-ray crystallography. …”

Enantiomeric Deoxycholic Acid:  Total Synthesis, Characterization, and Preliminary Toxicity toward Colon Cancer Cell Lines by Bryson W. Katona (2465581)

“…To further explore DCA induced changes in cell signaling, we completed a total synthesis of enantiomeric deoxycholic acid (<i>ent</i>-DCA) from achiral 2-methyl-1,3-cyclopentanedione. Using a modified method of the synthesis of <i>ent</i>-testosterone that proceeds through the (<i>R</i>)-(−)-Hajos−Parrish ketone, we have completed the successful synthesis of <i>ent</i>-DCA in 25 steps with a yield of 0.3% with all stereochemical assignments of the product confirmed by X-ray crystallography. …”

The effects of metformin, donepezil, insulin glargine, and glibenclamide on brain biomarkers: Amyloid β 42, nitric oxide, acetylcholinesterase, malondialdehyde, β secretase, and pM... by Shatw Khalid Ali (13020885)

A trial of seven footfalls in which the subject (emu) underwent a gradual deceleration. by P. J. Bishop (4219759)

Activity of miR-124 and miR-23a in NSC-derived neurons and astrocytes. by Annalisa Lattanzi (427545)

“…(B–E) A significant decrease of GFP expression is observed in bdLV.miRT124-transduced neurons (βtubIII, MAP2) (<b>B, C</b>) and in bdLV.miRT23a-transduced astrocytes (GFAP) and immature glial cells (nestin) (<b>D, E</b>). …”