G-protein coupled receptor experimental structures and their ligands used in this study. by Elizabeth Dong Nguyen (429088)

“…</p>b<p>Ligand conformers generated by MOE. The fold decrease in sampling efficiency is the uniform sampling efficiency within a 2.0 Å radius (USE2.0) for the bioactive ligand conformation divided by USE2.0 for ligand conformers.…”

Pathway-specific array analysis of cd45- [cd34+/kdr+]EPCs: impact of age, stroke susceptibility and sex. by Julius L. Decano (278584)

“…<p>Legend: 10-x inc, 10-fold increase in expression level over reference sample; 6 m, 6months; 4 m, 4 months; 2 m, 2 months; EPC, cd45- [cd34+/kdr+] endothelial progenitor cells; DEspR, dual endothelin1/VEGFsp receptor; f, female; m, male; nc, no change; nsp, non-stroke prone, sp, stroke prone; x, not detected, rep, reported involvement in vascular remodeling via intimal hyperplasia; all rat groups with n = 6; <i>P</i>-values, from 2-way ANOVA with multiple pairwise comparison, *, decrease in old compared to juvenile sample; inc, increase in old compared to juvenile sample; gene names, GenBank gene names.…”

Signalling via the Ras-RAF arm of ERK-MAPK is required for HCMV reactivation. by Verity G. Kew (577428)

“…Prior to addition of LPS or IL-6 cells were incubated with inhibitors of ERK, Raf or tpl2 signalling for 1 hour. IE RNA expression was expressed as a fold decrease compared to mock treated control <b>C</b>) immature DCs (1) were incubated with DMSO (2,3) or ERK (4,5), tpl2 (6,7) and Raf (8,9) inhibitors for 1 hour then stimulated with LPS (black) or IL-6 (grey) to promote reactivation. …”

NNRTI-resistance results obtained through phenotypic testing, direct sequencing and ultra-deep sequencing (UDPS). by Eva Agneskog (593818)

“…A fold-change of <5 was considered as sensitive, between 5–15 as decreased susceptibility, and above 15 as resistant. …”

Pulmonary gene signature after BCG vaccination but before <i>M. bovis</i> challenge. by Elihu Aranday Cortes (246656)

“…All VU samples (red squares at the bottom) were clustered together with two UU samples. Bright red represents a 3.4-fold increase in expression above the mean and bright blue represents a 3.4-fold change decrease in the expression from the average to all UU mice. …”

Model Predictions. by Carmen Pin (113170)

“…C) The time for the propagation of a mutation to the stem cell compartment is shorter when the mutation decreases the duration of the division cycle. …”

Comparison between OFF responses predicted by our model and neurobiological data. by Ulysse Rançon (15451568)

“…Thus, it could be that authors tested sounds too short compared to MGB time constants, resulting in a directly saturated effect. (<b>A</b>.) Adaptrans reproduces the decrease in offset response amplitude as a function of preceding fall-ramp duration. …”

Exercise reduces <i>C1qa</i>⁺ microglia/monocytes in the aged cortex. by Ileana Soto (531878)

“…(B) Quantification of IBA1⁺ cells in aging, aged sedentary (Sd), and aged runner (Rn) mice shows a decrease in microglia/monocyte density in the aged runners versus the aged sedentary mice. …”

Changes in antibody profiles between visits. by Bingyi Yang (633876)

“…We divided the changes in titers into four categories, i.e. decrease (green), no change (grey), two-fold increase (light purple) and four-fold change (seroconversion, dark purple).…”

Silencing of <i>MYCN</i> selectively alters genomic DNA binding of its cofactors. by Zhihui Liu (95891)

“…(<b>E</b>) IPA of the G9a ChIP-seq data shows that the G9a binding sites with decreased ChIP-seq signal (>1.2-fold decrease of G9a signal after the silencing of <i>MYCN</i>) associated genes are enriched in nervous system development. …”

Identification of Protozoa in Dairy Lagoon Wastewater that Consume <em>Escherichia coli</em> O157:H7 Preferentially by Subbarao V. Ravva (229603)

“…Although chemical, environmental and biological factors may be responsible for this decrease, we observed an 11-fold increase in native protozoa when wastewater was re-inoculated with 2×10⁷ cells of EcO157/mL. …”

Inhibition of collagen cleavage by prostaglandin E(PGE) and transforming growth factor (TGF)-β2 by Elena V Tchetina (38723)

“…<p><b>Copyright information:</b></p><p>Taken from "Prostaglandin PGEat very low concentrations suppresses collagen cleavage in cultured human osteoarthritic articular cartilage: this involves a decrease in expression of proinflammatory genes, collagenases and , a gene linked to chondrocyte hypertrophy"</p><p>http://arthritis-research.com/content/9/4/R75</p><p>Arthritis Research & Therapy 2007;9(4):R75-R75.…”

Seasonal Dynamics and Interannual Variability in Mercury Concentrations and Loads through a Three-Reservoir Complex by Austin K. Baldwin (3118449)

“…Seasonal export of MeHg was evidenced by increases in monthly mean concentrations of unfiltered MeHg (approximately 2-fold) and the percentage of total mercury (THg) as MeHg (≥4-fold) coincident with reservoir destratification. …”

Comparisons in mRNA levels of cytokines and receptors in pulmonary CD11c⁺ F4/80⁻ and CD11c⁻ F4/80⁺ cells in response to <i>M. pulmonis</... by Xiangle Sun (285335)

“…Data represent average value of two individual experiments.</p>d<p>Fold increase or decrease in cytokine mRNA levels in cells isolated from infected mice from the same cell type isolated from control mice.…”

Network pathway analysis of proteins identified in the BAL fluids of samples from i.a. challenged NHP 7 days post-infection, compared to samples from i.a. challenged NHP 5 days pos... by Anthony C. Marriott (111070)

“…Proteins in green highlight a 2-fold or more decrease in abundance in the NHP 7 days post-infection compared to samples from NHP 5 days post-infection. …”

Gene expression profile in the liver. by Tatsuya Uebi (161964)

“…Red and blue indicate the up- and down-regulated genes in <i>Sik3</i>^−/− mice, respectively. +, fold increase; -, fold decrease. The threshold is set at <i>p = </i>0.1. …”

Data_Sheet_1_Cost-effectiveness analysis of vaccination against COVID-19 in China.PDF by Huixuan Zhou (2146729)

“…Consequently, the strategy will lead to a saving of 37,664.77 CNY (US$5,256.70) and a gain of 0.50 QALYs per person per year on average (lifetime QALY and productivity loss due to immature death are included). …”

Cellular stress response-associated RNA changes and inferred signaling pathways. by Renée Deehan (326438)

“…<p>(<b>A</b>) Biologic processes associated with the cellular stress response inferred to increase or decrease upon treatment with aleglitazar, tesaglitazar or Pio/Feno. …”

DataSheet1_Potential drug-drug interaction of olverembatinib (HQP1351) using physiologically based pharmacokinetic models.docx by Zhiheng Yu (2433805)

“…The predicted results suggest that 1) strong, moderate, and mild CYP3A4 inhibitors (which have some overlap with CYP2C9 inhibitors) may increase olverembatinib exposure by approximately 2.39-, 1.80- to 2.39-, and 1.08-fold, respectively; strong, and moderate CYP3A4 inducers may decrease olverembatinib exposure by approximately 0.29-, and 0.35- to 0.56-fold, respectively 2); olverembatinib, as a “perpetrator,” would have no or limited impact on CYP1A2, CYP2B6, CYP2C9, CYP2C19, and CYP3A4 enzyme activity 3); systemic exposure of olverembatinib in liver function injury with Child-Pugh A, B, C may increase by 1.22-, 1.79-, and 2.13-fold, respectively. …”

Cell parameter sensitivity for switch cell islets. by Janita P. Hogan (10573758)