Novel Antagonist of the Type 2 Lysophosphatidic Acid Receptor (LPA₂), UCM-14216, Ameliorates Spinal Cord Injury in Mice by Nora Khiar-Fernández (8130210)

“…Toward validating this receptor as a target in SCI, we have developed a new series of LPA₂ antagonists, among which compound <b>54</b> (UCM-14216) stands out as a potent and selective LPA₂ receptor antagonist (<i>E</i>_max = 90%, IC₅₀ = 1.9 μM, <i>K</i>_D = 1.3 nM; inactive at LPA_1,3–6 receptors). …”

Novel Antagonist of the Type 2 Lysophosphatidic Acid Receptor (LPA₂), UCM-14216, Ameliorates Spinal Cord Injury in Mice by Nora Khiar-Fernández (8130210)

“…Toward validating this receptor as a target in SCI, we have developed a new series of LPA₂ antagonists, among which compound <b>54</b> (UCM-14216) stands out as a potent and selective LPA₂ receptor antagonist (<i>E</i>_max = 90%, IC₅₀ = 1.9 μM, <i>K</i>_D = 1.3 nM; inactive at LPA_1,3–6 receptors). …”

Table_1_Persistence of Mental Fatigue on Motor Control.pdf by Thomas Jacquet (9960275)

“…Fifteen participants performed an arm-pointing task consisting of reaching a target as fast as possible, before carrying out a 32-min cognitively demanding task [Time Load Dual Back (TLDB) task], and immediately, 10 and 20 min after completion of the TLDB task. …”

Data Sheet 1_Global burden of varicella and herpes zoster across 204 countries, 1990–2021: a temporal trend analysis in the era of the COVID-19 pandemic and projections to 2036.pdf... by Zilun Wu (18696883)

“…Mortality and DALYs declined significantly, with age-standardized mortality rates (ASMR) and DALYs rates (ASDR) decreasing by 50.0 and 36.3%, respectively. A stark disparity remains, with low-SDI regions accounting for over 67% of deaths and DALYs. …”

Synthesis and Biological Evaluation of Peripheral 5HT_2B Antagonists for Liver Fibrosis by Jihyeon Yoon (8705706)

“…<b>19c</b> markedly reduced fibrotic deposition, with a decrease in fibrosis stage and area in the CCl₄-induced liver fibrosis mouse model. …”

Synthesis and Biological Evaluation of Peripheral 5HT_2B Antagonists for Liver Fibrosis by Jihyeon Yoon (8705706)

“…<b>19c</b> markedly reduced fibrotic deposition, with a decrease in fibrosis stage and area in the CCl₄-induced liver fibrosis mouse model. …”

Proteomic Profiling Suggests Central Role Of STAT Signaling during Retinal Degeneration in the <i>rd10</i> Mouse Model by Alice Ly (2561908)

“…Alterations in the <i>rd10</i> retina proteome at pre-, peak-, and postdegenerative time points were examined using a modified high-recovery filter-aided sample preparation (FASP) method in combination with label-free quantitative mass spectrometry, generating a proteomic data set on almost 3000 proteins. …”

A randomized controlled trial of a combination of antiviral and nonsteroidal anti-inflammatory treatment in a bovine model of respiratory syncytial virus infection by Paul Walsh (662015)

“…Very early administration of ibuprofen and GS-561937, a fusion protein inhibitor (FPI), have separately been shown to decrease the severity of bovine RSV. …”

Lizards learn a spatial task in a closed-loop automated paradigm. by Tal Eisenberg (18078801)

“…Notice the strong increase for the third area (blue) and strong decrease for the second area. <b>(F)</b> Position trajectories over a single day (animal 1, block 3, day 3), segmented into stationary (gray dots marking mean location during stationary periods) and movement periods (colored lines). …”

Effects of VPA on zebrafish survival, hatching status, and development. by Sangwoo Lee (1727713)

Bone mesenchymal stem cells transplantation combined with mild hypothermia improves the prognosis of cerebral ischemia in rats by Min Bi (745889)

“…Our results showed that the combination therapy significantly decreased mNSS scores (P<0.01) and reduced the percentage of the infarct area (P<0.01) than a single treatment. …”

The colony front advances with a constant speed after a transient period. by Pintu Patra (412078)

“…The colony front has a sharp edge, which is a consequence of large decrease in diffusion rate below a threshold EPS level, which depends on the population density. …”

Annual total intake of cats per shelter. by W. J. R. van der Leij (7495688)

Image_3_DNMT3A R882 Mutations Confer Unique Clinicopathologic Features in MDS Including a High Risk of AML Transformation.tif by Majd Jawad (12157533)

“…By data mining with publicly accessible cancer genomics databases and a clinical genomic database from a tertiary medical institution, DNMT3A R882 mutations were found to be enriched in AML (53% of all DNMT3A mutations) but decreased in frequency in clonal hematopoiesis of indeterminate potential (CHIP) (10.6%) or other myeloid neoplasms including MDS (27%) (p<.001). …”

Image_1_DNMT3A R882 Mutations Confer Unique Clinicopathologic Features in MDS Including a High Risk of AML Transformation.tif by Majd Jawad (12157533)

“…By data mining with publicly accessible cancer genomics databases and a clinical genomic database from a tertiary medical institution, DNMT3A R882 mutations were found to be enriched in AML (53% of all DNMT3A mutations) but decreased in frequency in clonal hematopoiesis of indeterminate potential (CHIP) (10.6%) or other myeloid neoplasms including MDS (27%) (p<.001). …”

Image_2_DNMT3A R882 Mutations Confer Unique Clinicopathologic Features in MDS Including a High Risk of AML Transformation.tif by Majd Jawad (12157533)

“…By data mining with publicly accessible cancer genomics databases and a clinical genomic database from a tertiary medical institution, DNMT3A R882 mutations were found to be enriched in AML (53% of all DNMT3A mutations) but decreased in frequency in clonal hematopoiesis of indeterminate potential (CHIP) (10.6%) or other myeloid neoplasms including MDS (27%) (p<.001). …”

Table_2_DNMT3A R882 Mutations Confer Unique Clinicopathologic Features in MDS Including a High Risk of AML Transformation.docx by Majd Jawad (12157533)

“…By data mining with publicly accessible cancer genomics databases and a clinical genomic database from a tertiary medical institution, DNMT3A R882 mutations were found to be enriched in AML (53% of all DNMT3A mutations) but decreased in frequency in clonal hematopoiesis of indeterminate potential (CHIP) (10.6%) or other myeloid neoplasms including MDS (27%) (p<.001). …”

Table_1_DNMT3A R882 Mutations Confer Unique Clinicopathologic Features in MDS Including a High Risk of AML Transformation.docx by Majd Jawad (12157533)

“…By data mining with publicly accessible cancer genomics databases and a clinical genomic database from a tertiary medical institution, DNMT3A R882 mutations were found to be enriched in AML (53% of all DNMT3A mutations) but decreased in frequency in clonal hematopoiesis of indeterminate potential (CHIP) (10.6%) or other myeloid neoplasms including MDS (27%) (p<.001). …”

Effects of PoFbx23 protein on fungal growth, conidiation, and the transcription of genes involved in conidiation and spore pigment synthesis under glucose signal. by Zhongjiao Liu (11877464)

Postprandial glucose and insulin responses. by Elin Östman (9022661)