Loss of ALS2 results in decreased levels of the lysosome-dependent degradation of LC3 in fibroblasts. by Shinji Hadano (251529)

“…It is notable that a 6 hr of starvation leads to decreased levels of the LC3- and p62-immunoreactive signals in WT cells, but not in <i>Als2</i>^−/− cells. …”

Clinical features of Type 1 Diabetes (T1D) patients. by Adriana Carvalho-Santos (814114)

Subjects:

Juvenile demyelination leads to a substantial decrease in potassium currents in PV interneurons of the PFC. by Sara Hijazi (21656615)

“…Representative traces of TEA-sensitive potassium currents (1mM). <b>D</b>. TEA-sensitive currents were specifically decreased in PV interneurons from mice that received cuprizone treatment compared to control mice (<i>group x voltage two-way repeated measures: n = 10,14 cells from 5 mice per group: F(13,286) = 5.082, p < 0.0001</i>). …”

The fasting glucose (FG) levels are weakly negatively correlated with APRIL serum levels in diabetic patients. by Adriana Carvalho-Santos (814114)

Subjects:

Trehalose decreased PAN-induced apoptosis in human podocytes. by Yu-Lin Kang (663806)

“…<p>Podocyte were treated with PAN (30 µg/ml) or/and Trehalose (50 mM) for 48 h. (<b>A</b>) Trehalose induced autophagy in PAN-treated human podocytes. …”

HFD induces LDs and decreases ER and mitochondria in nephrocytes. by Aleksandra Lubojemska (10746241)

“…<b><a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3001230#pbio.3001230.s007" target="_blank">S2 Data</a></b> provides the source data used for all graphs and statistical analyses. …”

Antineoplastic Effects of siRNA against TMPRSS2-ERG Junction Oncogene in Prostate Cancer by Giorgia Urbinati (554921)

“…The siRNA against TMPRSS2-ERG fusion variant IV showed the highest anti-proliferative effects: Significantly decreased cell viability, increased cleaved caspase-3 and inhibited a cluster of anti-apoptotic proteins. …”

GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) by F. Anthony Romero (2452198)

“…In pursuit of a more potent and selective CBP inhibitor, we used structure-based design. …”

TL decreases cell viability in malignant cells dependent of p53 status. by Ajay Kumar (192967)

Systemic inhibition of TGF-β decreases retinal smad2 phosphorylation <i>in vivo</i>. by Tony E. Walshe (269700)

“…Scale = 50 µm. (D) Higher magnification of ppsmad2 staining in control mice, demonstrating nuclear pp-smad2 in retinal ECs (arrow). …”

Basal ubiquitination of GlyT2 in neurons decreases when the pool of free monomeric ubiquitin is reduced. by Jaime de Juan-Sanz (386083)

The ATR-CHK1 inhibitor AZD6738 decreases HBV cccDNA level. by Kaitao Zhao (3617825)

The three hit compounds decrease bacterial load of <i>Salmonella</i> in mammalian cells. by Abigail L. Reens (5349746)

Reductions in MEF2 expression do not impair PGE₂ decrease of <i>Sost</i>. by Damian C. Genetos (325684)

Deleting NspA decreases binding of fH to <i>N. meningitidis</i>. by Lisa A. Lewis (244867)

Proteasome activity was decreased in the <i>myc-rpt6-S119A</i> mutant. by Esther Magdalena Marquez-Lona (4183126)

“…The mean ± SEM rate of Suc-LLVY-AMC cleavage is decreased in the <i>myc-rpt6-S119A</i> mutant compared to the WT and <i>myc-rpt6-S119D</i> strains. …”

Wild-type SPOP increases, and the prostate cancer-associated SPOP mutants decrease, mitochondria average length. by Xiaofeng Jin (646436)

Hemodiafiltration Decreases Serum Levels of Inflammatory Mediators in Severe Leptospirosis: A Prospective Study by Sérgio Aparecido Cleto (3143949)

rhIL-4 and rhIL-13 decrease LEC proliferation and downregulate expression of Prox-1. by Ira L. Savetsky (749034)

A Functional 12T-Insertion Polymorphism in the <i>ATP1A1</i> Promoter Confers Decreased Susceptibility to Hypertension in a Male Sardinian Population by Victoria L. Herrera (383897)

“…To test the effects of decreased α1Na,K-ATPase expression on blood pressure, we measured blood pressure by radiotelemetry in three month-old, highly inbred heterozygous knockout <i>ATP1A1+/−</i> male mice with resultant 58% reduction in ATP1A1 protein levels. …”