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Protein arginine methyltransferase 5 (PRMT5) promotes survival of lymphoma cells via activation of WNT/B-catenin and AKT/GSK3B proliferative signaling
Published 2019“…We show that PRMT5 stimulates WNT/B-CATENIN signaling through direct epigenetic silencing of pathway antagonists, AXIN2 and WIF1, and indirect activation of AKT/GSK3 signaling.PRMT5 inhibition with either shRNA-mediated knockdown or a specific small molecule PRMT5 inhibitor, CMP-5, not only leads to derepression of WNT antagonists and decreased levels of active phospho-AKT (Thr-450 and Ser-473) and inactive phospho- GSK3B (Ser-9) but also results in decreased transcription of WNT/B-CATENIN target genes, CYCLIN D1, c-MYC, and SURVIVIN, and enhanced lymphoma cell death. …”
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Intercalation of ionic liquids into bentonite: Swelling and rheological behaviors
Published 2016“…The results from particle sizes and Zeta potential measurements have shown that bentonite intercalated with IL-1 and IL-2 are the most effective in decreasing the overall repulsive forces and increasing the attractive forces on the bentonite surface. …”
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Production and Determination of Bioavailable Iron in Sorghum and White bean Noodles
Published 2014“…Results of the study showed that the content of white bean in the noodles had a direct influence on the iron content and bioavailability. …”
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Umbelliferone inhibits spermatogenic defects and testicular injury in lead-intoxicated rats by suppressing oxidative stress and inflammation, and improving Nrf2/HO-1 signaling
Published 2020“…Materials and Methods: Rats received lead acetate (50 mg/kg) and UMB (25, 50 or 100 mg/kg) via oral gavage for 4 weeks. …”
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Chemical characterization and therapeutic properties of Achillea biebersteinii leaf aqueous extract synthesized copper nanoparticles against methamphetamine-induced cell death in P...
Published 2020“…The terminal deoxynucleotidyl transferase 2′-Deoxyuridine, 5′-Triphosphate (dUTP) nick end labeling test clarified the DNA fragmentation and apoptosis occurrence. …”
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Effect of sintering temperature of NBT–6BT lead-free ceramics on the structural, ferroelectric and piezoelectric properties
Published 2022“…It is found that the optimal ferroelectric and piezoelectric values were obtained at 1150 °C (P r = 27 µC/cm 2 , E c = 3.89 kV/mm and d 33 = 110 pC/N). According to these results, we suggest that 850 °C and 1150 °C can be considered as optimal calcination and sintering temperature in NBT-6BT ceramic, respectively.…”
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Contrasting cardiovascular mortality trends in Eastern Mediterranean populations: Contributions from risk factor changes and treatments
Published 2016“…Background Middle income countries are facing an epidemic of non-communicable diseases, especially coronary heart disease (CHD). We used a validated CHD mortality model (IMPACT) to explain recent trends in Tunisia, Syria, the occupied Palestinian territory (oPt) and Turkey. …”
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Inhibitory effect of sodium nitrite on corrosion of lead in 0.1 M sodium hydroxide solution
Published 1988“…The maximum inhibition efficiency is found to be 49.4% at 35°C and 45.9% at 50°C.…”
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A Modular Multilevel Voltage-Boosting Marx Pulse-Waveform Generator for Electroporation Applications
Published 2019“…In the BMPG, a controllable, low-voltage input boost converter supplies, via directing/blocking (D/B) diodes, two arms of a series modular multilevel converter half-bridge sub-modules (HB-SMs). …”
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Nanocomposite Ni-TiO2 coatings produced by pulsed electroplating
Published 2014“…Nanocomposite Ni-TiO2 coatings were prepared on mild steel substrate by pulse electroplating with controlled duty cycle and frequency. A systematic study of Ni-xTiO2 coatings with different TiO2 concentrations (x50-20 g L-1) has been conducted. …”
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Evaluation of Apoptotic, Antiproliferative, and Antimigratory Activity of Origanum syriacum against Metastatic Colon Cancer Cells
Published 2019“…Additionally, OSEE inhibited the migration of both LoVo and SW620 cells by decreasing (50–75%) wound-healing capacity at 500 and 1,000 μg mL−1. …”
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