Synthesis and biological evaluation of quinoxaline derivatives as ASK1 inhibitors by Xiaorui Han (1401655)

“…<p>Inhibiting apoptosis signal regulated kinase 1 (ASK1) is an attractive strategy for treating diseases such as non-alcoholic steatohepatitis and multiple sclerosis. Here, we report the discovery of a dibromo substituted quinoxaline fragment containing <b>26e</b> as an effective small-molecule inhibitor of ASK1, with an IC₅₀ value of 30.17 nM. …”

Sleep Duration and Cancer in the NIH-AARP Diet and Health Study Cohort by Fangyi Gu (266663)

“…A decreased ovarian cancer risk (HR_{≥ 9 vs. 7–8 hours} = 0.50; 95%CI:0.26–0.97) and an increased NHL risk (HR_{≥ 9 vs. 7–8 hours} = 1.45; 95%CI:1.00–2.11) were observed among long sleepers.…”

ADMET profile of screened compounds. by Aasia Kalsoom (18771234)

“…Our Morphological observation showed a significant difference in the cell morphology and proliferation potential which was decreased under the effect of plant extracts treatment as compared to the control samples. …”

Details of primers designed and ‘AZENTA’ IDs. by Aasia Kalsoom (18771234)

“…Our Morphological observation showed a significant difference in the cell morphology and proliferation potential which was decreased under the effect of plant extracts treatment as compared to the control samples. …”

Assessing the occurrence and transfer dynamics of ESBL/pAmpC-producing <i>Escherichia coli</i> across the broiler production pyramid by Ilias Apostolakos (5812853)

Optimized thermal profile for qPCR. by Aasia Kalsoom (18771234)

“…Our Morphological observation showed a significant difference in the cell morphology and proliferation potential which was decreased under the effect of plant extracts treatment as compared to the control samples. …”

Grid box dimensions for target proteins. by Aasia Kalsoom (18771234)

“…Our Morphological observation showed a significant difference in the cell morphology and proliferation potential which was decreased under the effect of plant extracts treatment as compared to the control samples. …”

Non-competitive inhibition of odorant activation of an insect OR by an Orco antagonist. by Sisi Chen (166395)

“…IC₅₀ values for OX1a inhibition of responses to 10nM 3MI (47 ± 5 µM), 100nM 3MI (42 ± 7 µM) and 1uM 3MI (50 ± 4 µM) did not differ (p=0.2970, F-test). …”

GRACEnet (Greenhouse gas Reduction through Agricultural Carbon Enhancement network) by USDA Agricultural Research Service (17476221)

“…Goals are to better quantify greenhouse gas GHG emissions from cropped and grazed soils under current management practices and to identify and further develop improved management practices that will enhance carbon (C) sequestration in soils, decrease GHG emissions, promote sustainability and provide a sound scientific basis for carbon credits and GHG trading programs. …”

Blue cone photoreceptors are efficiently ablated upon addition of prodrug. by Gordon F. Hagerman (3366290)

“…Bottom row: Blue cones are ablated, as shown in retinal sections of transgenic larvae treated with the prodrug. A decrease in the number of mCherry-positive blue cones (magenta) is apparent through 48 hours post ablation, followed by observation of mCherry-fluorescing blue cones at the ciliary marginal zone (panels G & H). …”

Adhesion of Als5 to collagen type IV involves recognition of carbohydrate residues on collagen type IV but is not solely determined by it. by Mohammad Faiz Ahmad (172608)

“…<p>(A) Adhesion of GST-Als5, GST-Als5-SS to collagen type IV. …”

Rapamycin aggravates neurodegeneration in fly model of FXTAS. by Yunting Lin (405839)

“…<b>a–c</b> LM images, <b>d–f</b> SEM images. The concentrations of rapamycin are: 0 μM (<b>a, d</b>), 2.5 μM (<b>b, e</b>), 5 μM (<b>c, f</b>). …”

Data_Sheet_1_Maternal Mental Health in Late Pregnancy and Longitudinal Changes in Postpartum Serum Vitamin B-12, Homocysteine, and Milk B-12 Concentration Among Brazilian Women.doc... by Mônica Araujo Batalha (13026525)

“…Women with anxiety symptoms at baseline exhibited a decrease in daily postpartum homocysteine concentrations compared to women without anxiety symptoms (β = −0.002, SE = 0.001, p = 0.024).…”

DataSheet_1_The effects of sucrose and arsenic on muscular insulin signaling pathways differ between the gastrocnemius and quadriceps muscles.docx by Pablo Pánico (15429539)

“…</p>Methods<p>Male Wistar rats were treated with 20% sucrose (S), 50 ppm sodium arsenite (A), or both (A+S) in drinking water for 8 weeks. …”

Development of erlotinib-loaded nanotransferosomal gel for the topical treatment of ductal carcinoma<i> in situ</i> by Bharti Mangla (16929094)

“…Furthermore, we treated breast cancer cells with the developed gel using a method called MTT assay and the results showed improved cell-killing activity in comparison to plain drug. …”

Table_1_Effects of Aleurone Supplementation on Glucose-Insulin Metabolism and Gut Microbiome in Untrained Healthy Horses.docx by Berit Boshuizen (3747655)

“…Seven adult Standardbred horses were supplemented with four different dose levels of aleurone (50, 100, 200, and 400 g/day for 1 week) by using a Latin square model with a 1-week wash out in between doses. …”

The effect of sGP on immune response when antigen exposure mimics natural infection. by Gopi S. Mohan (111744)

“…<p>(A) Immunization study design. Female BALB/C mice were immunized IM with 50 µg of total DNA per immunization according to the schedule shown. …”

Data_Sheet_1_Effects of Aleurone Supplementation on Glucose-Insulin Metabolism and Gut Microbiome in Untrained Healthy Horses.docx by Berit Boshuizen (3747655)

“…Seven adult Standardbred horses were supplemented with four different dose levels of aleurone (50, 100, 200, and 400 g/day for 1 week) by using a Latin square model with a 1-week wash out in between doses. …”

Table_1_The Isolate Caproiciproducens sp. 7D4C2 Produces n-Caproate at Mildly Acidic Conditions From Hexoses: Genome and rBOX Comparison With Related Strains and Chain-Elongating B... by Sofia Esquivel-Elizondo (4438618)

“…However, this was considerably higher at 83.1 ± 0.44% when both fructose and n-butyrate (electron acceptor) were combined as a substrate. A comparison of 7D4C2 cultures with fructose and n-butyrate with an increasing pH value from 4.5 to 9.0 showed a decreasing n-caproate specificity from ∼92% at mildly acidic pH (pH 4.5-5.0) to ∼24% at alkaline pH (pH 9.0). …”

Data_Sheet_1_The Isolate Caproiciproducens sp. 7D4C2 Produces n-Caproate at Mildly Acidic Conditions From Hexoses: Genome and rBOX Comparison With Related Strains and Chain-Elongat... by Sofia Esquivel-Elizondo (4438618)

“…However, this was considerably higher at 83.1 ± 0.44% when both fructose and n-butyrate (electron acceptor) were combined as a substrate. A comparison of 7D4C2 cultures with fructose and n-butyrate with an increasing pH value from 4.5 to 9.0 showed a decreasing n-caproate specificity from ∼92% at mildly acidic pH (pH 4.5-5.0) to ∼24% at alkaline pH (pH 9.0). …”