Modulation of PIP₂ levels by PLC activity in INS-1 and RyR2^KO cells. by Kyle E. Harvey (4375987)

“…Carbachol stimulated a greater decrease in PH-PLCδ-GFP fluorescence intensity in control INS-1 cells than in RyR2^KO cells (***, <i>P</i> < 0.001). 2-APB significantly inhibited this decrease in control INS-1 cells (****, <i>P</i> < 0.0001), but not in RyR2^KO cells. …”

Downregulation of ATM1 affects iron-sulfur cluster proteins in <i>Toxoplasma</i> and iron levels in <i>Plasmodium</i>. by Deepti Shrivastava (17715780)

“…Unchanged proteins are displayed in black, while significantly altered proteins are displayed in grey (< 1.5-fold change (FC), local false discovery rate, LFDR < 0.05) or in blue (>1.5-fold increased; LFDR < 0.05) or red (> 1.5-fold decreased; LFDR < 0.05). …”

Effects of different parameters on Rnf2 binding. by Nikolaj Dietrich (181521)

“…Densities, within each bin, depend on the number of peaks, whereas the color-coding corresponds to the average Rnf2<i>_Rest−/−</i>/Rnf2<i>_Wt</i> ratio with red, green and blue illustrating increased, unaffected, or decreased signal, respectively. Peaks were binned in 1.5 fold bins for Suz12 and 2 fold bins for the TSS or CpG position. …”

Impact of modifications to periplasmic volume around optimal solution of ABC cell at nutrient concentration of 1 nM. by Noele Norris (10826554)

In vivo reporter assays uncover changes in enhancer activity caused by type 2 diabetes associated SNPs by Ada Admin (8524211)

4 EC Performance on Structural Genomics test set. by Eric Venner (235381)

<i>In silico</i> clinical trials suggest little efficacy for corticosteroids or DAMP inhibitors. by Cordelia Ziraldo (221649)

TNIP1 abrogates the profibrotic effects of proinflammatory cytokines on collagen synthesis by SSc fibroblatsts. by Yannick Allanore (58641)

“…<p>(A,B) SSc dermal fibroblasts treated with recombinant TNFa or IL1β and incubated 24 hours with TNIP1 displayed decreased mRNA levels for (A) <i>COL1A1</i> (1.6 and 1.5-fold reduction, <i>P</i> = 0.02 and 0.04, respectively) and (B) <i>COL1A2</i> (1.7 and 1.8-fold reduction, <i>P</i> = 0.02 and 0.009, respectively). …”

TNIP1 abrogates the profibrotic effects of proinflammatory cytokines on collagen synthesis by healthy fibroblatsts. by Yannick Allanore (58641)

“…<p>(A,B) Healthy dermal fibroblasts treated with recombinant Il1β or Il6 and incubated 24 hours with TNIP1 displayed decreased mRNA levels for (A) <i>COL1A1</i> (1.6 and 1.4-fold reduction, <i>P</i> = 0.01 and 0.03, respectively) and (B) <i>COL1A2</i> (1.7 and 1.6-fold reduction, <i>P</i> = 0.02 and 0.03, respectively). …”

Table_1_Identification of Cardiomyopathy-Associated Circulating miRNA Biomarkers in Muscular Dystrophy Female Carriers Using a Complementary Cardiac Imaging and Plasma Profiling Ap... by Anca Florian (3542324)

“…Among the circulating miRNAs examined, six were significantly up-regulated in MD carriers compared to female controls: miR-206 (103-fold increase, p < 0.0001), miR-222 (41-fold, p < 0.0001), miR-26a (fourfold, p = 0.029), miR-342 (27-fold, p < 0.0001), miR-378a-3p (minimum 3,600-fold; almost undetectable in controls, p = 0.013), miR-378a-5p (64-fold, p < 0.0001); only two miRNAs were substantially down-regulated in MD carriers: miR-144 (p < 0.0001) and miR-29a (p = 0.002) (both undetectable in carriers). …”

Table_2_Identification of Cardiomyopathy-Associated Circulating miRNA Biomarkers in Muscular Dystrophy Female Carriers Using a Complementary Cardiac Imaging and Plasma Profiling Ap... by Anca Florian (3542324)

“…Among the circulating miRNAs examined, six were significantly up-regulated in MD carriers compared to female controls: miR-206 (103-fold increase, p < 0.0001), miR-222 (41-fold, p < 0.0001), miR-26a (fourfold, p = 0.029), miR-342 (27-fold, p < 0.0001), miR-378a-3p (minimum 3,600-fold; almost undetectable in controls, p = 0.013), miR-378a-5p (64-fold, p < 0.0001); only two miRNAs were substantially down-regulated in MD carriers: miR-144 (p < 0.0001) and miR-29a (p = 0.002) (both undetectable in carriers). …”

<i>pals-17</i> mutant phenotypes are fully <i>pals-16</i>-dependent. by Vladimir Lažetić (5047592)

“…<p>(A, B) <i>pals-16</i> RNAi decreases <i>pals-5</i>p::GFP expression in <i>pals-17 pals-20</i> mutants. …”

Replication and spread of virus in the brain after intranasal infection with NSV. by Eun-Young Lee (329320)

“…<p>Representative thalamus sections from the brains of at least 3 WTB6, GRKO and GKO mice 3, 5 and 7 days after intranasal infection with 10⁵ pfu NSV were stained with rabbit polyclonal antibody to NSV followed by biotinylated antibody to rabbit IgG, avidin-peroxidase and DAB. …”

UCH-L5 regulates inflammasome activity in chicken macrophages. by Evangel Kummari (719636)

“…</b> UCH-L5 was overexpressed in HD11 macrophages (UCH-L5) and empty vector was used as a control (ctrl). 24-hours past overexpression, the cells were subjected to <i>Salmonella</i> infection at MOI of 50:1 for 18-hours (inf) or left uninfected. …”

Y-27632 mediated signal transduction during differentiation. by Roman J. Krawetz (309735)

“…<p>Total mRNA collected from all groups was converted to cDNA and probed to assay levels of β-catenin (A). β-catenin levels increased under all differentiation induction conditions, however, levels decreased significantly when Y-27632 was added during mesodermal and ectodermal differentiation. …”

Effect of aspirin on endometrial histomorphometry in PCOS rats during the window of implantation. by Ying Zhang (40767)

“…(HE staining, scare bar = 50μm). <b>(a)</b> Control group, the endometrial stroma is loose, with synchronous development of glands and stroma, abundant glands, and a rich vascular supply; <b>(b)</b> Model group, endometrial glandular hypoplasia is observed, characterized by small glandular lumina and a reduced number of glands, along with a decrease in vascularity; <b>(c)</b> Aspirin group, endometrial development shows improvement, manifested by larger glandular lumina, loose stroma, and an increased number of glands and vessels within the stroma. …”

SINGLE PORT LAPAROSCOPIC CHOLECYSTECTOMY: TECHNICAL ASPECTS AND RESULTS by Murillo de Lima FAVARO (5670416)

“…The mean surgical time was 67.97 min, showing a marked decrease when was reached close to 50 cases and a stabilization after 100 surgeries. …”

Increased TCR avidity of memory CD4+ T cells in HIV controllers. by Benoît Vingert (252525)

“…<p>(A) The TCR avidity of Gag293-specific CD4+ T cells was determined by MHC class II tetramer staining in the presence of decreasing tetramer concentrations. …”

Sensitivity to starvation increases after knockdown of sNPF and DTK in neurosecretory cells. by Lily Kahsai (233920)

“…<b>C</b> Kurs 6-driven knockdown of DTK produces strongly diminished survival at starvation (about 12 h decrease at 50% survival) (P<0.001, Log-rank test; for each genotype n = 224–229).…”

Perifosine targets the Aldefluor-positive cell population in breast cancer xenografts. by Hasan Korkaya (159560)

“…<p>(A–C). 50,000 cells from SUM159 cell line or two breast cancer xenografts, MCI, or UM2 were injected into NOD/SCID mice and the tumor size was monitored. …”