Supplementary file 1_Pharmacokinetic and pharmacodynamic analyses of nafamostat in ECMO patients: comparing central vein and ECMO machine samples.pdf by Dong Hwan Lee (9908916)

“…NM was shown to inhibit the decrease in aPTT in the turnover model. In the patient model, the maximum inhibitory effect (Imax) of NM on the reduction of aPTT was 35.5%, and the concentration of NM required to achieve half of this maximum effect (IC50) was 350 μg/L. …”

Membrane currents and evoked calcium transients. by Saju Balakrishnan (58265)

“…<p><b><i>A</i>–</b>Sample HCN and calcium currents evoked by voltage steps to -50 and -110 mV, respectively, from the holding potential -70 mV, close to the measured resting potential. …”

Co-delivery of free vancomycin and transcription factor decoy-nanostructured lipid carriers can enhance inhibition of methicillin resistant <i>Staphylococcus aureus</i> (MRSA) by Alan Hibbitts (6818348)

“…However, the efficient protection and delivery of the TFDs inside the bacterial cells is a critical step for the success of this technology. …”

AMPK activators reduce DVL3 in cervical cancer cells. by H. T. Kwan (291038)

“…(B) Upon treatment of A769662 at different doses (0, 50 and 100 μM), a 20-30% and 80%–100% reduction of DVL3 in SiHa and C33A could be observed respectively. …”

Stomatal development and responses are impaired in specific <i>crks</i>. by Gildas Bourdais (502310)

“…<p><b>(A)</b> A subset of the <i>crk</i> mutants showed altered water loss (shown as decrease of fresh weight) compared to Col-0 wild type plants after detachment of shoots from roots as evaluated from rosette weight. …”

Phase Behavior and Self-Assembly of Semiflexible Polymers in Poor-Solvent Solutions by Tobia Arcangeli (19540447)

Neurons from Kidins220^−/− mice showed normal post-tetanic potentiation and synaptic depression of evoked EPSCs. by Joachim Scholz-Starke (324807)

“…<p><b>A</b>) EPSCs recorded using a paired-pulse protocol (IPI = 50 ms) are presented before (left trace) and after (right trace) the application of a 1-s stimulation train at 40 Hz (middle trace). …”

Frontal crash seat belt restraint effectiveness and comfort accessories used by older occupants by Tom Whyte (3911467)

datasheet1_Hepatic Cytochrome P450 Abundance and Activity in the Developing and Adult Göttingen Minipig: Pivotal Data for PBPK Modeling.docx by Laura Buyssens (10651334)

“…These data are remarkably comparable to human data and provide a valuable step forward in the construction of a neonatal and juvenile Göttingen Minipig PBPK model.…”

DNA barcodes of 38 plant species by Tingting Shen (21584966)

Data_Sheet_1_Staphylococcus aureus Infection Influences the Function of Intestinal Cells by Altering the Lipid Raft-Dependent Sorting of Sucrase–Isomaltase.PDF by AhmedElmontaser Mergani (11271159)

“…The data show that there is no significant change in the overall expression levels of SI in the infected versus non-infected cells as assessed by Western blotting analysis using monoclonal anti-SI antibodies. By contrast, a significant decrease in the localization as well as the specific hydrolytic activities of SI toward sucrose and isomaltose (Palatinose) was observed in the BBM (P2 fraction) in Caco-2 cells 48 h post-infection. …”

Mechanistic framework predicts drug-class specific utility of antiretrovirals for HIV prophylaxis by Sulav Duwal (152805)

“…Notably, some drugs from this candidate set are patent-expired and currently neglected for PrEP repurposing. A next step is to further trim this candidate set by ruling out compounds with ominous safety profiles, to assess different administration schemes in silico and to test the remaining candidates in human trials.…”

DataSheet1_Wave Equation Numerical Simulation and RTM With Mixed Staggered-Grid Finite-Difference Schemes.docx by Wei Liu (20030)

“…For acoustic wave modeling, with almost identical computational costs, M-SFD can achieve higher modeling accuracy than C-SFD. Moreover, with a larger time step used in M-SFD than that used in C-SFD, M-SFD can achieve higher computational efficiency and reach higher modeling accuracy. …”

Proposed epigenetic regulatory mechanism during the somatic embryogenesis of <i>Coffea canephora</i>. by Geovanny I. Nic-Can (448043)

“…These findings suggest that dynamic changes in chromatin could be a crucial step for switching genes on or off during the dedifferentiation and differentiation events to develop a somatic embryo. …”

Table_1_Effects of dietary arginine supplementation on growth performance, antioxidant capacity, intestinal digestive enzyme activity, muscle transcriptome, and gut health of Sinip... by Liyun Ding (3944732)

“…Fish fed a 3.37% arginine diet had the highest TSOD activity in the serum and liver. …”

DataSheet1_qInward variability-based in-silico proarrhythmic risk assessment of drugs using deep learning model.PDF by Da Un Jeong (13914843)

“…We performed the action potential (AP) simulation using a human ventricular myocyte model to calculate seven in silico features representing the electrophysiological cell states of drug effects over 1,000 beats: qNet, qInward, intracellular calcium duration at returning to 50% baseline (CaD50) and 90% baseline (CaD90), AP duration at 50% repolarization (APD50) and 90% repolarization (APD90), and dVm/dtMax_repol. …”

Anteriorly traveling Lfng stripes and segmentation-clock period. by Susan D. Hester (204004)

“…We increase or decrease the segmentation-clock period by varying how long we integrate the segmentation-clock ODEs during each time step; by doing so, we easily vary the clock period relative to other processes in the simulation without altering parameters within the segmentation-clock submodel or changing the clock response to FGF8, Wnt3a or Delta/Notch signaling. …”

Serum stimulates PLY oligomer formation. by Kristin R. Wade (625971)

“…The decrease in emission intensity of D is dependent on the formation of the oligomer <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1004353#ppat.1004353-Harris1" target="_blank">[47]</a>. …”

CRISPR/Cas9-mediated knockout of <i>c-REL</i> in HeLa cells results in profound defects of the cell cycle by Carsten Slotta (4326091)

Pathway schematic depicting changes that occurred in measured metabolites, gene expression, and enzymatic activities for central metabolism during the transition from succinate to... by Elizabeth Skovran (236606)

“…<p>A boxed gene/protein name indicates the activity of this enzyme was measured. …”