Discovery of Arylsulfonamides as Dual Orexin Receptor Agonists by Dehui Zhang (1332363)

“…This work provides a promising dual small molecule agonist and supports development of orexin agonists as potential treatments for orexin-deficient disorders such as narcolepsy.…”

The species origin of the serum in the culture medium influences the <i>in vitro</i> toxicity of silica nanoparticles to HepG2 cells by Cédric Pisani (4348027)

“…Using human compared with fetal bovine serum, nanoparticle toxicity in HepG2 cells decreased by 4-fold and 1.5-fold, when used at 50 and 10μg/mL, respectively. …”

Phytohormone pretreatment mitigates the negative impacts of salt stress on the germination of common buckwheat seeds (<i>Fagopyrum esculentum</i>) by Congfei Yin (6505796)

“…In this study, our results shown the germination rate decreased with increasing NaCl concentration. The effect of four different synthetic phytohormones (ethephon; gibberellin, GA3; 6-benzylaminopurine, 6-BA; and naphthalene acetic acid, NAA) at different concentrations on the germination of seeds under low (50 mmol L⁻¹ NaCl) and high (100 mmol L⁻¹ NaCl) concentration of salt stress have been investigated. …”

Towards coupling agent-free composites made from regenerated cellulose/HDPE by UV radiation-induced cross-linking by Raja Bade (20550622)

“…The primary focus is to establish a cross-linking mechanism between cellulose fibres and polyethylene by applying UV irradiation to a UV-transparent matrix and UV-absorbing fibres. …”

27-OHC induces NF-κB activation and subsequently increases NF-κB-mediated BACE1 expression. by Gurdeep Marwarha (443735)

“…<p>(a,b) 27-OHC significantly increases the levels of the p65 and the p50 subunits of the NF-κB in the nuclear homogenates, and (c–e) increases the protein and mRNA levels of BACE1; treatment with the NF-κB inhibitor sc514 attenuates the 27-OHC-induced increase in protein and mRNA expression of BACE1. …”

Effects of 1-Ethyl-3-(3-Dimethylaminopropyl) Carbodiimide on Adhesion of Posts in Teeth Obturated With Different Sealers by Beatriz Serrato Coelho (10439939)

“…Regarding the bond strength, a significant difference between the EDC and CON subgroups occurred only in the END (p=0.001). …”

Table1_Tizoxanide Promotes Apoptosis in Glioblastoma by Inhibiting CDK1 Activity.docx by Si Huang (5006288)

“…In vitro, TIZ dose-dependently inhibited the proliferation of U87, U118, and A172 human glioblastoma (GBM) cells at 48 h with IC₅₀ values of 1.10, 2.31, and 0.73 µM, respectively. …”

MicroRNA-96 Directly Inhibits γ-Globin Expression in Human Erythropoiesis by Imane Azzouzi (211962)

“…The overexpression of microRNA-96 in human <em>ex vivo</em> erythropoiesis decreased γ-globin expression by 50%, whereas the knock-down of endogenous microRNA-96 increased γ-globin expression by 20%. …”

The morphological characterization of the dry seeds and reserve mobilization during germination in Morinda citrifolia L. by Stelamaris de Oliveira Paula (12805418)

“…The lipids were mobilized during germination, suffering a reduction of up to 38% of its total. Proteins, as well as lipids decreased by 25.78% during the germination period observed. …”

Discovery of Arylsulfonamides as Dual Orexin Receptor Agonists by Dehui Zhang (1332363)

“…This work provides a promising dual small molecule agonist and supports development of orexin agonists as potential treatments for orexin-deficient disorders such as narcolepsy.…”

IRE-1 is required for dendrite growth in dissociated hippocampal neurons. by Yehuda Salzberg (631553)

“…Dendrite tip number did not increase with development, however 4μ8C-treated cultures exhibited a non-significant trend towards reduced tip number reflecting decreased dendrite complexity. …”

Percent correct responses (diamond symbols) during consecutive blocks of 20 trials. by Alyson Blount (9188423)

“…Lines between symbols connect blocks in the same session. <b>A.</b> Initial blocks for four mice, two discriminating 1,000 ppm limonene (LIM) <b>R</b> vs. …”

Oxygen regulates neurotrasmitter phenotypes of IhNSC-derived neurons. by Guido Santilli (255380)

“…(A) Quantification of the percentage of GABAergic neurons (GABA+) over the total nuclei (DAPI+) number, at 17 days. Values are means±S.E.M (N = 3). At 17 days, the percentage of GABA+ cells significantly decreased in 1% O₂ and 20% O₂ with respect to mild hypoxia conditions. …”

Inhibition of AKR1B1 substrate oxidation by β-glucogallin. by Muthenna Puppala (175119)

“…C) No significant changes were observed in the apparent K_m values. D) A decreasing trend was observed in the apparent V_max values, and the differences were found to be statistically significant as follows: *indicates <i>P</i> = 0.01, and ***indicates <i>P</i> = 0.0002. …”

Chronic ethanol exposure increases microtubule content in PC12 cells by Cindy K Reiter-Funk (7788)

“…We found no significant differences between these two cells types). Data are the mean +/- SEM. Asterisks represent significant differences from corresponding control (p < 0.001). …”

Physical quality and organic matter fractions of an Alfisol under no-tillage by Diony Alves Reis (5221958)

“…SPD deployment time increased Pt, Ma, and EstC, and decreased Mi, RP, Ds. NT promotes MWD, ILC, IEC, and IMC after five years of deployment, and, therefore, it improves soil physical quality.…”

Results from the first culturally tailored, multidisciplinary diabetes education in Lebanese adults with type 2 diabetes: effects on self-care and metabolic outcomes by Sukkarieh-Haraty, Ola

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Intracerebral ventricular infusion of IL-1β receptor antagonist prevents blood-brain-barrier disruption induced by Nef expression in the rat hippocampus. by Jocelyn Rivera (2276668)

“…<b>(B)</b> Quantitative analysis of BBB tight junction claudin-5 showed that Nef decreased (by twofold) the expression of the tight junction compared to Nef with the IL-1β receptor antagonist in both hemispheres. …”

Increased lipid availability for three days reduces whole body glucose uptake, impairs muscle mitochondrial function and initiates opposing effects on PGC-1α promoter methylation i... by Roy Eldor (380760)

DataSheet_1_The effects of sucrose and arsenic on muscular insulin signaling pathways differ between the gastrocnemius and quadriceps muscles.docx by Pablo Pánico (15429539)

“…</p>Methods<p>Male Wistar rats were treated with 20% sucrose (S), 50 ppm sodium arsenite (A), or both (A+S) in drinking water for 8 weeks. …”