Identification of <em>Orch3</em>, a Locus Controlling Dominant Resistance to Autoimmune Orchitis, as Kinesin Family Member 1C by Roxana del Rio (108216)

“…Mechanistically, we showed that the resistant <em>Kif1c^D2</em> allele leads to a reduced antigen-specific T cell proliferative response as a consequence of decreased MHC class II expression by antigen presenting cells, and that the L⁵⁷⁸→P⁵⁷⁸ and S¹⁰²⁷→P¹⁰²⁷ polymorphisms distinguishing the BALB/cByJ and DBA/2J alleles, respectively, can play a role in transcriptional regulation. …”

Correlated Evolution of Positions within Mammalian cis Elements by Rithun Mukherjee (280865)

“…We report a <em>Maximum-Likelihood</em> (<em>ML</em>) approach to infer correlated evolution at any two positions within a PWM, based on a multiple alignment of 5 mammalian genomes. …”

Anthropogenic CO2–induced seawater acidification driven the biogeochemical processes of dimethylsulfide in Northwestern Pacific marginal seas by Xuxu Gao (9724883)

“…Low pH can also suppress DMS biological production and microbial consumption rates and increase DMS photolysis rate, resulting in lower DMS emissions. We estimated that the decreased DMS emission caused by seawater acidification, would account for up to 35% of DMS flux in the marginal seas under the RCP8.5 high-emission scenario. …”

Optical Inline Interferometer for Enhanced Low-Field Detection via Electric-Field Induced Second Harmonic Generation by Jean-Baptiste Billeau (18886201)

“…Furthermore, we successfully measured an electric field as low as 32 V/cm with an SNR of 7.4 during 0.15 s measurement time, estimating an unprecedented detection limit of 1.7 V/(cm Hz^0.5). …”

Image_3_Netrin-1 Ameliorates Postoperative Delirium-Like Behavior in Aged Mice by Suppressing Neuroinflammation and Restoring Impaired Blood-Brain Barrier Permeability.TIF by Ke Li (106849)

“…We found that a single dose of NTN-1 prophylaxis decreased the expression of IL-6 and HMGB-1 and upregulated the expression of IL-10 in the peripheral blood, hippocampus, and prefrontal cortex. …”

Data_Sheet_2_Risperidone Mitigates Enhanced Excitatory Neuronal Function and Repetitive Behavior Caused by an ASD-Associated Mutation of SIK1.PDF by Moataz Badawi (11080101)

“…SIK1-MT protein was distributed in the nucleus and cytoplasm, whereas the distribution of wild-type SIK1 was restricted to the nucleus. We found the disruption of excitatory and inhibitory (E/I) synaptic balance due to an increase in excitatory synaptic transmission and enhancement of neural excitability in the pyramidal neurons in layer 5 of the medial prefrontal cortex in SIK1-MT mice. …”

Image_3_Risperidone Mitigates Enhanced Excitatory Neuronal Function and Repetitive Behavior Caused by an ASD-Associated Mutation of SIK1.TIFF by Moataz Badawi (11080101)

“…SIK1-MT protein was distributed in the nucleus and cytoplasm, whereas the distribution of wild-type SIK1 was restricted to the nucleus. We found the disruption of excitatory and inhibitory (E/I) synaptic balance due to an increase in excitatory synaptic transmission and enhancement of neural excitability in the pyramidal neurons in layer 5 of the medial prefrontal cortex in SIK1-MT mice. …”

Image 1_CAMDA 2023: Finding patterns in urban microbiomes.tiff by Haydeé Contreras-Peruyero (20320404)

“…We then implemented supervised models conducting 5-fold cross-validation (CV) with a 4:1 training-to-validation ratio. …”

Video_1_Force and Stepwise Movements of Gliding Motility in Human Pathogenic Bacterium Mycoplasma pneumoniae.AVI by Masaki Mizutani (11476414)

“…We detected stepwise movements, likely caused by a single leg under 0.2-0.3 mM free sialylated oligosaccharides. …”

Image_2_Risperidone Mitigates Enhanced Excitatory Neuronal Function and Repetitive Behavior Caused by an ASD-Associated Mutation of SIK1.TIFF by Moataz Badawi (11080101)

“…SIK1-MT protein was distributed in the nucleus and cytoplasm, whereas the distribution of wild-type SIK1 was restricted to the nucleus. We found the disruption of excitatory and inhibitory (E/I) synaptic balance due to an increase in excitatory synaptic transmission and enhancement of neural excitability in the pyramidal neurons in layer 5 of the medial prefrontal cortex in SIK1-MT mice. …”

Fibronectin Matrix Assembly Suppresses Dispersal of Glioblastoma Cells by Joshua Sabari (203453)

“…Previous studies have reported that increased cell-cell cohesion can markedly reduce invasion by discouraging cell detachment from the tumor mass. We have previously reported that α5β1 integrin-fibronectin interaction is a powerful mediator of indirect cell-cell cohesion and that the process of fibronectin matrix assembly (FNMA) is crucial to establishing strong bonds between cells in 3D tumor-like spheroids. …”

Image_2_Netrin-1 Ameliorates Postoperative Delirium-Like Behavior in Aged Mice by Suppressing Neuroinflammation and Restoring Impaired Blood-Brain Barrier Permeability.TIF by Ke Li (106849)

“…We found that a single dose of NTN-1 prophylaxis decreased the expression of IL-6 and HMGB-1 and upregulated the expression of IL-10 in the peripheral blood, hippocampus, and prefrontal cortex. …”

Autoinactivation of the Stargazin–AMPA Receptor Complex: Subunit-Dependency and Independence from Physical Dissociation by Artur Semenov (121893)

“…<div><p>Agonist responses and channel kinetics of native α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors are modulated by transmembrane accessory proteins. …”

HuR antagonizes the effect of an intronic pyrimidine-rich sequence in regulating WT1 +/−KTS isoforms by Hui Li (32376)

“…The +/−KTS isoforms were generated by alternative usage of two adjacent 5′ splice sites at RNA level, however, how these two isoforms are regulated is still elusive. …”

Video_2_Force and Stepwise Movements of Gliding Motility in Human Pathogenic Bacterium Mycoplasma pneumoniae.AVI by Masaki Mizutani (11476414)

“…We detected stepwise movements, likely caused by a single leg under 0.2-0.3 mM free sialylated oligosaccharides. …”

Image_1_Netrin-1 Ameliorates Postoperative Delirium-Like Behavior in Aged Mice by Suppressing Neuroinflammation and Restoring Impaired Blood-Brain Barrier Permeability.TIF by Ke Li (106849)

“…We found that a single dose of NTN-1 prophylaxis decreased the expression of IL-6 and HMGB-1 and upregulated the expression of IL-10 in the peripheral blood, hippocampus, and prefrontal cortex. …”

Harm Reduction Policy Support among Students at Two U.S. Universities by Barbara Andraka-Christou (8153934)

“…We analyzed data using descriptive statistics and logistic regressions. …”

Image_1_Central Treatment of Ketone Body in Rainbow Trout Alters Liver Metabolism Without Apparently Altering the Regulation of Food Intake.pdf by Sara Comesaña (5689613)

“…Using rainbow trout (Oncorhynchus mykiss) as a model, we intracerebroventricularly (ICV) administered 1 μl 100 g^–1 body mass of saline solution alone (control) or containing 0.5 μmol of BHB. …”

Experiment 2. by Lalit Pandey (13195488)

“…<p><b>(A)</b> We increased the number of hardcoded spatial operations by adding more layers to the CNN architecture. …”

Loss of the HPV-Infection Resistance EVER2 Protein Impairs NF-κB Signaling Pathways in Keratinocytes by Françoise Vuillier (5657947)

“…Finally, we demonstrate that EVER2 loss induces constitutive PKCα-dependent c-jun phosphorylation and facilitates activation of the HPV5 long control region through a JNK-dependent pathway. …”