Image_10_Canonical and Non-canonical TGFβ Signaling Activate Autophagy in an ULK1-Dependent Manner.TIF by Charles B. Trelford (11601802)

“…We demonstrated that TGFβ1 increases Unc 51-like kinase 1 (ULK1) protein levels, 5′ adenosine monophosphate-activated protein kinase (AMPK)-dependent ULK1 phosphorylation at serine (S) 555 and ULK1 complex formation but decreases mechanistic target of rapamycin (mTOR) activity on ULK1. …”

Image_2_Neuroimmune pathways involvement in neurodegeneration of R6/2 mouse model of Huntington’s disease.tif by Emanuela Paldino (499905)

“…Such activity is mediated by the inhibition (dephosphorylation) of the proteins signal transducer and activator of transcription (STAT). We found that activated SHP-1 was present in microglia and neurons of WT mice at 5 and 13 weeks, increasing with time; while in R6/2 it was not localized in neurons but only in microglia, where it decreases with time. …”

A standardized extract of Centella asiatica (ECa 233) prevents temporomandibular joint osteoarthritis by modulating the expression of local inflammatory mediators in mice by Nattapon ROTPENPIAN (10409963)

“…Methodology A mouse model was induced by analyzing the CFA-injected TMJ on days 7, 14, and 21. We assessed TMJ histology by the osteoarthritis cartilage grade score. …”

Trends of cause-specific cardiovascular disease mortality in China, 2009-2019: a nationwide longitudinal study by Lu Wang (45927)

“…The CMR of all CVD increased [the annual average percentage change (AAPC) = 3.4%, 95% confidence interval (CI) 2.6% to 4.1%] while the ASMR decreased (AAPC = −2.0%, 95% CI −3.5% to −0.6%). Cerebrovascular disease is predicted to be the leading cause of CVD death in men and IHD will be the top cause of CVD death in women over the period 2025-2029.…”

Image_7_Canonical and Non-canonical TGFβ Signaling Activate Autophagy in an ULK1-Dependent Manner.TIF by Charles B. Trelford (11601802)

“…We demonstrated that TGFβ1 increases Unc 51-like kinase 1 (ULK1) protein levels, 5′ adenosine monophosphate-activated protein kinase (AMPK)-dependent ULK1 phosphorylation at serine (S) 555 and ULK1 complex formation but decreases mechanistic target of rapamycin (mTOR) activity on ULK1. …”

Supplementary Material for: Cancer associated fibroblasts induce proliferation and therapeutic resistance to everolimus in neuroendocrine tumors through STAT3 activation by Amin T. (14226773)

“…STAT3 activation in NET tissue was associated with de-creased chromogranin A expression, increased Ki-67 index and decreased 5-year overall and progression free survival. …”

Image_1_Saccharomyces Boulardii Ameliorates Non-alcoholic Steatohepatitis in Mice Induced by a Methionine-Choline-Deficient Diet Through Gut-Liver Axis.TIF by An-Ming Yang (12436298)

“…For this study, we fed eight-week-old C57/BL6 male mice either a methionine-choline deficient (MCD) diet or a normal chow diet (NCD) for eight weeks. …”

Image_2_Canonical and Non-canonical TGFβ Signaling Activate Autophagy in an ULK1-Dependent Manner.TIF by Charles B. Trelford (11601802)

“…We demonstrated that TGFβ1 increases Unc 51-like kinase 1 (ULK1) protein levels, 5′ adenosine monophosphate-activated protein kinase (AMPK)-dependent ULK1 phosphorylation at serine (S) 555 and ULK1 complex formation but decreases mechanistic target of rapamycin (mTOR) activity on ULK1. …”

Image_1_Transcriptome Analysis of Endogenous Hormone Response Mechanism in Roots of Styrax tonkinensis Under Waterlogging.TIF by Hong Chen (108084)

“…To explore endogenous hormones and phytohormone-related molecular response mechanism of S. tonkinensis under waterlogging, we determined 1-aminocyclopropane-1-carboxylic acid (ACC) and three phytohormone content (ABA, abscisic acid; SA, salicylic acid; IAA, indole-3-acetic acid) and analyzed the transcriptome of its seedlings under waterlogged condition of 3–5 cm. …”

Supplementary Material for: Highly Selective Endothelin-1 Receptor A Inhibition Prevents Bleomycin-Induced Pulmonary Inflammation and Fibrosis in Mice by Manitsopoulos N. (4577806)

“…<b><i>Objectives:</i></b> We addressed the role of highly selective ET-1 receptor A (ETA) inhibition in the pathogenesis of experimental pulmonary fibrosis by bleomycin (BLM). …”

Table_2_Trichostatin A, a Histone Deacetylase Inhibitor, Alleviates Eosinophilic Meningitis Induced by Angiostrongylus cantonensis Infection in Mice.DOCX by Yanhua Zhang (356457)

“…Intragastric administration of TSA significantly ameliorated brain injury and decreased cognitive impairments in mice at 15 days post-infection. …”

Data_Sheet_1_Saccharomyces Boulardii Ameliorates Non-alcoholic Steatohepatitis in Mice Induced by a Methionine-Choline-Deficient Diet Through Gut-Liver Axis.docx by An-Ming Yang (12436298)

“…For this study, we fed eight-week-old C57/BL6 male mice either a methionine-choline deficient (MCD) diet or a normal chow diet (NCD) for eight weeks. …”

Effect of cytochalasin D. by Angelika Kunze (736927)

“…The full width at half maximum of the dissipation signal decreases about 50% ± 14% (calculated by a set of three experiments). …”

<i>In silico</i> inflammation profiles of aging in human tissues: Sex-specific lymphocyte signatures in skin. by William R. Swindell (175427)

“…Dark red colors indicate cases in which signature transcripts for a given cell population increase with age (i.e., the ratio of age-increased to age-decreased signature transcripts is greater than one). …”

Prevalence of malnutrition may impact global viral evolutionary patterns. by Rebekah Honce (9238696)

“…<p>Worldwide rates of obesity are projected to reach over 50% by 2050. Additionally, undernutrition of both children and adults continues to be a global health crisis. …”

Effect of on Bepridil on APP processing. by Kamran Honarnejad (485648)

“…Sulindac sulfide (50 µM) was used as a γ-secretase modulator control. …”

Mu but not delta opioid receptor expressing interneurons are recruited by the SC pathway. by Xavier Rezai (5656768)

“…Representative traces and corresponding time course. * or ^#, p<0.05, ** or ^##, p<0.01 versus baseline or drug respectively. Scale bar 50 pA/500 ms for sIPSC and 100 pA/10 ms for SC-eIPSC.…”

Image_4_Retrospective investigation of the origin and epidemiology of the dengue outbreak in Yunnan, China from 2017 to 2018.TIF by Liang Cao (135383)

Image_1_Retrospective investigation of the origin and epidemiology of the dengue outbreak in Yunnan, China from 2017 to 2018.TIF by Liang Cao (135383)

Image_3_Retrospective investigation of the origin and epidemiology of the dengue outbreak in Yunnan, China from 2017 to 2018.TIF by Liang Cao (135383)