Organ burden of inhaled nanoceria in a 2-year low-dose exposure study: dump or depot? by Jutta Tentschert (1277127)

“…The CeO₂ burden for lung, lung-associated lymph nodes, and major non-pulmonary organs, blood, and feces, was determined in a chronic whole-body inhalation study in female Wistar rats undertaken according to OECD TG453 (6 h per day for 5 days per week for a 104 weeks with the following concentrations: 0, 0.1, 0.3, 1.0, and 3.0 mg/m³, animals were sacrificed after 3, 12, 24 months). …”

Polymorphisms of microRNA Sequences or Binding Sites and Lung Cancer: A Meta-Analysis and Systematic Review by Zhiwei Chen (254191)

“…Methodological quality of eligible studies was adequate with an average score of 8.5. miRNA-196a2 rs11614913 polymorphism was associated with increased lung cancer risk (homozygote comparison, OR = 1.299, 95% CI: 1.096–1.540; dominant model, OR = 1.217, 95% CI: 1.041–1.421) and decreased survival. …”

Estimating the Effect of Liver and Pancreas Volume and Fat Content on Risk of Diabetes: A Mendelian Randomization Study by Susan Martin (6648740)

“…MR analysis provided evidence only for a causal role of liver fat and pancreas volume on risk of type 2 diabetes (1.27 [1.08,1.49] or 27% increased risk and 0.76 [0.62,0.94] or 24% decreased risk per 1SD, respectively) and no causal associations with type 1 diabetes.…”

Image_1_Dry Eye and Phacoemulsification Cataract Surgery: A Systematic Review and Meta-Analysis.TIF by Qiang Lu (49688)

“…Patients with pre-existing meibomian gland dysfunction (MGD) had worsened subjective symptoms of dry eye (1.31, 95% confidence interval (CI) [0.66, 1.95], P < 0.0001), a reduced tear break-up time (BUT) (−2.27, 95% CI [−2.66, −1.88], P < 0.0001), and a worse corneal fluorescein staining (CFS) score (0.75, 95% CI [0.5, 1.0], P < 0.0001) after phacoemulsification cataract surgery, whereas in the general population, the subjective symptoms score and CFS remained unchanged and BUT decreased slightly after surgery. …”

Image_1_Identification and characterization of a novel CASR mutation causing familial hypocalciuric hypercalcemia.tif by Chien-Ming Lin (740034)

“…</p>Objective<p>A 45-year-old male presenting with moderate hypercalcemia, hypocalciuria, and inappropriately high parathyroid hormone (PTH) had a good response to cinacalcet (total serum calcium (Ca²⁺) from 12.5 to 10.1 mg/dl). …”

Table_2_Retinal microvasculature features in patients with migraine: a systematic review and meta-analysis.XLSX by Yulian Pang (14002071)

“…Background<p>Migraine is a central nervous system disorder involving neuronal and vascular factors. …”

Image_2_Identification and characterization of a novel CASR mutation causing familial hypocalciuric hypercalcemia.tif by Chien-Ming Lin (740034)

“…</p>Objective<p>A 45-year-old male presenting with moderate hypercalcemia, hypocalciuria, and inappropriately high parathyroid hormone (PTH) had a good response to cinacalcet (total serum calcium (Ca²⁺) from 12.5 to 10.1 mg/dl). …”

Taxes on Sugar-Sweetened Beverages to Reduce Overweight and Obesity in Middle-Income Countries: A Systematic Review by Sharon S. Nakhimovsky (3138477)

“…Estimates for own-price elasticity ranged from -0.6 to -1.2, and decreases in SSB consumption ranged from 5 to 39 kilojoules per person per day given a 10% increase in SSB prices. …”

Lack of Functional Benefit with Glutamine versus Placebo in Duchenne Muscular Dystrophy: A Randomized Crossover Trial by Elise Mok (264326)

“…</p><h3>Methodology/Principal Findings</h3><p>30 ambulant DMD boys were included in this double-blind, randomized crossover trial with 2 intervention periods: glutamine (0.5 g/kg/d) and placebo, 4 months each, separated by a 1-month wash-out, at 3 outpatient clinical investigation centers in France. …”

Table_1_Causal effect of iron status on lung function: A Mendelian randomization study.docx by Zhimin Yu (2258896)

“…</p>Results<p>Based on conservative genetic instruments, MR analyses showed that genetically predicted higher iron (beta: 0.036 per 1 SD increase, 95% confidence interval (CI): 0.016 to 0.056, P = 3.51 × 10⁻⁴), log10-transformed ferritin (beta: 0.081, 95% CI: 0.047 to 0.116, P = 4.11 × 10⁻⁶), and transferrin saturation (beta: 0.027, 95% CI: 0.015 to 0.038, P = 1.09 × 10⁻⁵) were associated with increased forced expiratory volume in 1 s (FEV1), whereas higher transferrin was associated with decreased FEV1 (beta: −0.036, 95% CI: −0.064 to −0.008, P = 0.01). …”

Economic and public health impact of decentralized HIV viral load testing: A modelling study in Kenya by M. de Necker (6407402)

“…The GeneXpert system is a diagnostic point-of-care technology that can quantify, amongst others, HIV VL. …”

Proteomics Analysis of Human Obesity Reveals the Epigenetic Factor HDAC4 as a Potential Target for Obesity by Mohamed Abu-Farha (25322)

“…Using this approach, a total of 47 proteins showed at least 1.5 fold change between lean and obese subjects. …”

Spontaneous cephalic version and risk factors for persistent breech presentation: a longitudinal retrospective cohort study by Zehong Zhou (6927917)

“…Female fetus, lateral or fundal placenta, and known uterine malformation was each associated with an increased odd of 1.4 (aOR, 95% CI, 1.11–1.70), 2.4 (aOR, 95% CI,1.50–3.73), 3.1 (aOR, 95% CI, 1.71–5.53) and 8.7 (aOR, 95% CI, 3.84–19.84) times in the persistent breech presentation, respectively.…”

Image_2_Dry Eye and Phacoemulsification Cataract Surgery: A Systematic Review and Meta-Analysis.TIF by Qiang Lu (49688)

“…Patients with pre-existing meibomian gland dysfunction (MGD) had worsened subjective symptoms of dry eye (1.31, 95% confidence interval (CI) [0.66, 1.95], P < 0.0001), a reduced tear break-up time (BUT) (−2.27, 95% CI [−2.66, −1.88], P < 0.0001), and a worse corneal fluorescein staining (CFS) score (0.75, 95% CI [0.5, 1.0], P < 0.0001) after phacoemulsification cataract surgery, whereas in the general population, the subjective symptoms score and CFS remained unchanged and BUT decreased slightly after surgery. …”

Quantifying skeletal muscle volume and shape in humans using MRI: A systematic review of validity and reliability by Christelle Pons (5196740)

“…Segmentation on one slice (n = 11) increased volume errors. The Deformation of a Parametric Specific Object (DPSO) method (n = 5) decreased the number of manually-segmented slices required for any chosen level of error. …”

Table_2_Dry Eye and Phacoemulsification Cataract Surgery: A Systematic Review and Meta-Analysis.XLSX by Qiang Lu (49688)

“…Patients with pre-existing meibomian gland dysfunction (MGD) had worsened subjective symptoms of dry eye (1.31, 95% confidence interval (CI) [0.66, 1.95], P < 0.0001), a reduced tear break-up time (BUT) (−2.27, 95% CI [−2.66, −1.88], P < 0.0001), and a worse corneal fluorescein staining (CFS) score (0.75, 95% CI [0.5, 1.0], P < 0.0001) after phacoemulsification cataract surgery, whereas in the general population, the subjective symptoms score and CFS remained unchanged and BUT decreased slightly after surgery. …”

Table_1_Dry Eye and Phacoemulsification Cataract Surgery: A Systematic Review and Meta-Analysis.DOC by Qiang Lu (49688)

“…Patients with pre-existing meibomian gland dysfunction (MGD) had worsened subjective symptoms of dry eye (1.31, 95% confidence interval (CI) [0.66, 1.95], P < 0.0001), a reduced tear break-up time (BUT) (−2.27, 95% CI [−2.66, −1.88], P < 0.0001), and a worse corneal fluorescein staining (CFS) score (0.75, 95% CI [0.5, 1.0], P < 0.0001) after phacoemulsification cataract surgery, whereas in the general population, the subjective symptoms score and CFS remained unchanged and BUT decreased slightly after surgery. …”

Table_1_Lactobacillus (Limosilactobacillus) reuteri: a probiotic candidate to reduce neonatal diarrhea in calves.DOCX by Karin Schwaiger (14004423)

“…Since the probability of occurrence of diarrheal disease decreases as the L. reuteri count in the feces increases, oral administration of this species might have a protective effect against diarrhea.…”

<i>In situ</i> Proximity Ligation Assay (PLA) for TUSC2 protein in tumor biopsies (A). by Charles Lu (33589)

“…Detailed methods are provided in the <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0034833#pone.0034833.s001" target="_blank">Information S1</a>. …”

Image_1_Causal effect of iron status on lung function: A Mendelian randomization study.pdf by Zhimin Yu (2258896)

“…</p>Results<p>Based on conservative genetic instruments, MR analyses showed that genetically predicted higher iron (beta: 0.036 per 1 SD increase, 95% confidence interval (CI): 0.016 to 0.056, P = 3.51 × 10⁻⁴), log10-transformed ferritin (beta: 0.081, 95% CI: 0.047 to 0.116, P = 4.11 × 10⁻⁶), and transferrin saturation (beta: 0.027, 95% CI: 0.015 to 0.038, P = 1.09 × 10⁻⁵) were associated with increased forced expiratory volume in 1 s (FEV1), whereas higher transferrin was associated with decreased FEV1 (beta: −0.036, 95% CI: −0.064 to −0.008, P = 0.01). …”