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1_ mean » _ mean (Expand Search), 19 means (Expand Search)
a decrease » _ decreased (Expand Search), _ decreases (Expand Search)
e decrease » _ decreased (Expand Search), _ decreases (Expand Search), a decreased (Expand Search)
1_ mean » _ mean (Expand Search), 19 means (Expand Search)
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The decrease or inhibition of Hsp90 induced REST degradation.
Published 2019“…(D) The level of REST dramatically reduced in differentiated SH-SY5Y cells treated with GA (1 μM) or PU-H71 (50 nM) at 24 h. (E) The REST level decreased by GA more than 50% and (F) PU-H71 more than 80%, respectively. …”
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AKT inhibition decreases neuroblast populations.
Published 2012“…SOX2 is expressed in the otic epithelial neuroblast population (a, arrowhead) and it is significantly increased in presence of IGF-I (b, arrowhead, e) but it is markedly reduced in the presence of either AKTi or LY (c and d, arrowheads, e). …”
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At lower concentrations, METH decreases LTP.
Published 2010“…Insets are 30-msec sweeps taken from representative experiments illustrating the average of fEPSPs 0–5 min prior to (solid line) and 55–60 min post-tetanus (dotted line, horizontal dashed lines are 1 mV apart). At 0.1 µM METH, LTP was 1.58±.08 [<i>n</i> = 13(5)] (Fig. 1B); at 1 µM METH, LTP was 1.50±.07 [<i>n</i> = 13(7)] (Fig. 1C); at 10 µM METH, LTP was 1.58±.07 [<i>n</i> = 14(8)] (Fig. 1D); at 30 µM METH, LTP was 1.37±.06 [<i>n</i> = 15(4)] (Fig. 1E); and at 60 µM METH, LTP was 1.32±.24 [<i>n</i> = 4(2)] (Fig. 1E). …”
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