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The rate of lariat formation is decreased two-fold by isoginkgetin treatment.
Published 2014“…The indicated values are from an average of three biological replicates, and <i>p</i>-values are from two-tailed <i>t</i>-tests based on mean values for aggregated introns 2–10 (n = 9). …”
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Resveratrol decreases PKM2 expression.
Published 2013“…<p>Resveratrol treatment decreases PKM2 mRNA in (A), HeLa; (B), HepG2 and (C), MCF-7; by approximately two-folds. β-actin was taken as endogenous control and normalized to PKM2 mRNA. …”
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FTY720 decreased viability, proliferation, and motility and induced apoptosis in human hepatoblastoma cells.
Published 2019“…<p>(A) Following 24 hours of treatment with FTY720, the viability of HuH6 cells measured using the alamarBlue cell viability assay was significantly decreased (LD<sub>50</sub> = 8.4 μM, p ≤ 0.05). …”
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Beta-catenin signaling is decreased in intermediate progenitor cells.
Published 2010“…Scale bars are 50 µm. * * = P<0.001, t test, two-tailed. (<b>C</b>) To further quantify signaling differences between Tbr2+ and Tbr2- cells, dorsolateral neocortices from E13.5 Eomes::GFP embryos (n = 3) were FACS sorted for GFP+ and GFP- cells (see cartoon). mRNA from these cells was isolated and reverse transcribed into cDNA for real-time PCR analysis. …”
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TUDCA decreases ER stress in HOX neonatal rat lungs.
Published 2022“…<p>(<b>A</b>) The expression levels of ER stress markers (P-PERK 0.6±0.1-fold, p<0.001, n = 5; PERK 0.7±0.1-fold, p = 0.00364, n = 5; P-IRE1α 0.6±0.0-fold, p<0.001, n = 5; IRE1α 0.6±0.1-fold, p<0.001, n = 5; GRP78 0.8±0.1-fold, p<0.001, n = 5; cleaved ATF6 0.1±0.0-fold, p<0.001, n = 5; spliced XBP1 0.3±0.0-fold, p<0.001, n = 5; 2 males and 3 females) are all decreased while the N-glycosylated VEGFR2 is increased (3.5±0.2-fold, p<0.001, n = 5) in HOX neonatal lungs at P10 indicating TUDCA can attenuate hyperoxia-induced ER stress. …”
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Decreased macrophage recruitment correlates with decreased angiogenesis.
Published 2013“…Scale bars represent 50 µM. Results in each figure panel are representative of a minimum of three different mice for each treatment group and genotype.…”
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GFRα2 expression was dramatically decreased in Runx1 knockout mice.
Published 2013“…GFRα2 and Runx1 decreased concurrently. GFRα1 and GFRα3 increased at 6 d post transection confirming previous rat ISH studies. …”
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<i>Kdm6a</i> conditional KO mice have decreased repopulating potential in serial competitive transplantation assays.
Published 2021“…Significant differences in the chimerism of SLAM cells compared to whole BM were found in KO-F mice (55.2-fold increase in CD45.2<sup>+</sup> KO-F SLAM cells as compared to CD45.2<sup>+</sup> cells in the whole BM, p = 0.0163) and KO-M mice (11.31-fold increase in CD45.2<sup>+</sup> KO-M SLAM cells as compared to CD45.2<sup>+</sup> cells in the whole BM, p = 0.0010). …”
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