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Decreased E/I synapse ratio and loss of cortico-LA synaptic plasticity in the absence of coronin 1.
Published 2014“…Strong cortico-LA LTP was induced in wild-type [WT (grey symbols), <i>n</i> = 12, <i>p</i><0.05 versus baseline, <i>p</i><0.05 versus Cor 1 −/− (red symbols), Student's <i>t</i> test), but not in coronin 1–deficient mice [Cor 1 −/− (red), <i>n</i> = 7, <i>p</i>>0.05 versus baseline, Student's <i>t</i> test]. Scale bars, 50 pA and 20 ms. (G) Synaptic transmission and PPR in wild-type (left) and coronin 1–deficient mice (right) in the presence of forskolin. …”
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Elevated IDO activity in HD mouse brains is decreased by <i>ex-vivo</i> iron chelation.
Published 2021“…<p>Mouse pups were supplemented with carbonyl iron from postnatal days 10–17 and then were sacrificed at 14 weeks of age. <b>A.</b> Striatal IDO activity is increased in N171-82Q HD mice and significantly decreased by <i>ex vivo</i> iron (III) chelation (50 μM deferoxamine). …”
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