Overexpression of U1 snRNA induces decrease of U1 spliceosome function associated with Alzheimer’s disease by Zhi Cheng (729515)

“…These findings not only helped researchers better understand the functions of U1 snRNA, but also paved the way to reveal the mechanisms of AD from a different point of view and may find a new therapeutic target for the disease.…”

<i>Becn1</i>^FA/FA mutation ameliorates cerebral Aβ accumulation, memory deficits and mortality of Alzheimer’s mouse models. by Altea Rocchi (3278457)

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The <i>Becn1</i> F121A mutation inhibits the BECN1-BCL2 interaction in vivo. by Altea Rocchi (3278457)

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Autophagosomal sequestration of Aβ42 in brain of autophagy-hyperactive mice. by Altea Rocchi (3278457)

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An autophagy-inducing compound ML246 reduces amyloid load in an autophagy-dependent manner in vitro and in vivo. by Altea Rocchi (3278457)

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A <i>Becn1</i> mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease by Altea Rocchi (3278457)

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<i>Becn1</i>^F121A improves the survival rate of PDAPP AD mice. by Altea Rocchi (3278457)

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Effect of dexmedetomidine (5 μg∙kg⁻¹ or 50 μg∙kg⁻¹) at experimental recording (Protocol 1). by Yoichiro Kitajima (4319455)

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Mice carrying 100P mutations show region-specific decreases in proportions of PV-expressing cells. by Malgorzata Borkowska (3166719)

Nonmetric multidimensional scaling ordination of vascular plants in a matrix of 93 plots x 36 species along the DMTS haul road in Cape Krusenstern National Monument, Alaska. by Peter N. Neitlich (4034300)

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Space impression evaluated using the SDM (7-point Likert scale). by Hiroyuki Fukumoto (18197728)

The second-order rate-yield tradeoff demonstrated by decreasing the P/O ratio and and knocking out <i>gnd</i> (“Δ<i>gnd</i>”) in ME-model simulations. by Chuankai Cheng (6791417)

Dexmedetomidine (Dex) reversed isoflurane-induced inhibition of Akt activity and decrease of Bcl-xL/Bad ratio in the hippocampus of P7 rats (n = 7 in each group). by Yujuan Li (554062)

<i>sf3b1</i> mutant strains are defective in reproduction, development and fungi-infection resistance. by Bei Zhang (428038)

“…Fecundity was measured over a period of 12 days from females crossed with the <i>WT</i> males, and each time point represents data from ten female adults. …”

BrdU incorporation is elevated in clrn1-/- zebrafish at 4 mpf and decreases with age. by Hannah J. T. Nonarath (20861735)

“…Quantification of Brdu+ nuclei in the (e) outer nuclear layer (ONL, or Photoreceptor layer) and (f) inner nuclear layer (INL) revealed an increase in BrdU incorporation for <i>clrn1</i>^<i>-/-</i> zebrafish at the youngest time point which decreased with age. White arrows highlight BrdU+ nuclei. …”

Mean scores and 95% CIs according to SARS-CoV-2 infection status and work-related determinants. by A. H. Ayesha Lavell (16734002)

Intrathecal KN93 injection attenuated fentanyl-induced hyperalgesia and decreased the level of <i>p</i>-CaMKIIα in spinal cord but not CeLC in OIH rats. by Zhen Li (1234644)

Ni causes a decrease in membrane sterols in A549 lung epithelial cells. by Amber R. Matha (19681603)

Delphinidin alters VEGF-A splicing to increase VEGF-A₁₆₅b and decrease total VEGF-A expression. by Megan Stevens (3964886)

“…<b>C)</b> Under both NG and HG condition, delphinidin significantly decreased the protein expression of total VEGF-A₁₆₅ (*p<0.05; n = 3 biological repeats; One-way ANOVA with Bonferroni post-hoc test for comparison between pairs). …”

Knockdown of MRN complex decreases HBV cccDNA level. by Kaitao Zhao (3617825)