Gene clustering identifies up- and down-regulated groups that control development, pluripotency, and cell division. by Michael Shelton (382572)

“…<p>Pluripotent H9 hESCs were differentiated for 50 days as previously described [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0222946#pone.0222946.ref012" target="_blank">12</a>], beginning with high (7.5 μM or 10 μM) CHIR99021 concentrations. mRNA samples from the indicated time points were subjected to gene expression profiling. …”

<i>Becn1</i>^FA/FA mutation ameliorates cerebral Aβ accumulation, memory deficits and mortality of Alzheimer’s mouse models. by Altea Rocchi (3278457)

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The <i>Becn1</i> F121A mutation inhibits the BECN1-BCL2 interaction in vivo. by Altea Rocchi (3278457)

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Autophagosomal sequestration of Aβ42 in brain of autophagy-hyperactive mice. by Altea Rocchi (3278457)

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An autophagy-inducing compound ML246 reduces amyloid load in an autophagy-dependent manner in vitro and in vivo. by Altea Rocchi (3278457)

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A <i>Becn1</i> mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease by Altea Rocchi (3278457)

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<i>Becn1</i>^F121A improves the survival rate of PDAPP AD mice. by Altea Rocchi (3278457)

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(a) the wild type with SHV in the left panel and its neighbors in the wild type are shown (b) the S130G mutant in the right panel and its neighbors in the mutant type its neighbors... by Mohd Hassan Baig (441304)

Overexpression of U1 snRNA induces decrease of U1 spliceosome function associated with Alzheimer’s disease by Zhi Cheng (729515)

“…These findings not only helped researchers better understand the functions of U1 snRNA, but also paved the way to reveal the mechanisms of AD from a different point of view and may find a new therapeutic target for the disease.…”

Decreased numbers of motor neurons in Tc1 and Dp(16)1Yey mice. by Sheona Watson-Scales (586942)

Mice carrying 100P mutations show region-specific decreases in proportions of PV-expressing cells. by Malgorzata Borkowska (3166719)

Space impression evaluated using the SDM (7-point Likert scale). by Hiroyuki Fukumoto (18197728)

The second-order rate-yield tradeoff demonstrated by decreasing the P/O ratio and and knocking out <i>gnd</i> (“Δ<i>gnd</i>”) in ME-model simulations. by Chuankai Cheng (6791417)

BrdU incorporation is elevated in clrn1-/- zebrafish at 4 mpf and decreases with age. by Hannah J. T. Nonarath (20861735)

“…Quantification of Brdu+ nuclei in the (e) outer nuclear layer (ONL, or Photoreceptor layer) and (f) inner nuclear layer (INL) revealed an increase in BrdU incorporation for <i>clrn1</i>^<i>-/-</i> zebrafish at the youngest time point which decreased with age. White arrows highlight BrdU+ nuclei. …”

Ni causes a decrease in membrane sterols in A549 lung epithelial cells. by Amber R. Matha (19681603)

S1 Dataset - by Hendricus Nijland (15198278)

“…Mechanical strength was examined with a three-point bending test for ablations in the diaphysis and with an indentation test for ablations in the metaphysis.…”

According to the initial retention time of individuals, the dynamics of dispersion of groups of 40 woodlice (a) and the time necessary to disperse 50% of the population introduced... by Pierre Broly (228993)

According to number of woodlice initially introduced, the dynamics of the dispersion of groups held for 300 s (a) and the time necessary to disperse 50% of the population introduce... by Pierre Broly (228993)

Join-point regression analysis of the statistically significant linear increase in use of antidementia and antipsychotics during the observed time period. by Jelena Filimonovic (22305307)

Delphinidin alters VEGF-A splicing to increase VEGF-A₁₆₅b and decrease total VEGF-A expression. by Megan Stevens (3964886)

“…<b>C)</b> Under both NG and HG condition, delphinidin significantly decreased the protein expression of total VEGF-A₁₆₅ (*p<0.05; n = 3 biological repeats; One-way ANOVA with Bonferroni post-hoc test for comparison between pairs). …”