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641
Increased osteoblastic activity and decreased osteoclastogenesis in TgLRAP cells <i>in vitro</i>.
Published 2021“…Compared with the co-culture of WT BMCs and WT calvarial cells (WT / WT), the number of osteoclasts were significantly decreased at 50% in the co-cultures of TgLRAP BMCs and TgLRAP calvarial cells (TgLRAP / TgLRAP) (graph). …”
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642
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643
Desmosomal Cadherins Are Decreased in Explanted Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Patient Hearts
Published 2013“…Genetic studies have demonstrated the central role of desmosomal proteins in this disease, where 50% of patients harbor a mutation in a desmosmal gene. …”
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644
Aspirin decreases expression of NFκB and β-catenin in colon cancer cells.
Published 2013“…<p>Decreased p65/p50 in RKO (A) and SW480 (B) cells. Cells were treated for 48 hr with 5 or 10 mM, and whole cell, nuclear and cytosolic extracts were analyzed by western blot analysis as described in the <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0048208#s3" target="_blank">Experimental Procedures</a>. …”
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645
Decreased ISCs and increased goblet cells after intestinal specific loss of MLL1.
Published 2021“…(C) Decrease in ISC markers, OLFM4 and SOX9 in <i>Mll1</i><sup><i>FC/FC; Vil-Cre-ERT2/+</i></sup> intestinal sections. …”
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646
DHT increases whereas orchidectomy decreases the weight and cross sectional area of hindlimb muscles.
Published 2013“…<b>A:</b> In WT mice, DHT increased the GN weight by 7% (212.4±8.8 mg), whereas orchidectomy decreased it by 14% (171.4±9.0 mg) compared with control WT mice (198.4±5.5 mg). …”
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647
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648
Simultaneous ablation of Syt1 and Syt7 decreases the RRP size at excitatory synapses.
Published 2015“…<p><b>A & B.</b> Ablation of both Syt1 and Syt7 in hippocampal neurons decreases the RRP size at excitatory synapses in a manner that is rescued by WT Syt7 (Syt7<sup>WT</sup>) or Syt1 (Syt1<sup>WT</sup>) but not by mutant Syt7 (Syt7<sup>C2A</sup>*<sup>B</sup>*) or Syt1 (Syt1<sup>C2A</sup>*<sup>B</sup>*) with altered top-loop sequences containing the Ca<sup>2+</sup>-binding sequences (A, Syt7 rescue; B, Syt1 rescue). …”
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649
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650
Decreased sensitivity of coculture HIV spread to RAL predicts multiple infections per cell.
Published 2016“…Blue dashed line represents parametrization of the cell-free infection response to RAL in terms of IC<sub>50</sub> (1.9 nM) and hill coefficient (0.7). Red dashed line represents the fit of coculture infection using the decreased sensitivity to RAL (<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1005964#sec008" target="_blank">Materials and methods</a>). …”
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651
GBE did not modify cell morphology but decreased reactive oxygen species (ROS) levels.
Published 2010“…<b>C</b>) Mitochondria-associated ROS levels measured after incubation with DHR (DHR fluorescence units/1×10<sup>5</sup> cells). ROS levels showed a trend to be increased in APP cells compared to control cells (<sup>(</sup>*<sup>)</sup>p = 0.082, unpaired student's t-test, n = 11, values represent the means ± S.E.). …”
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652
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653
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654
Image_5_Consecutive Hypoxia Decreases Expression of NOTCH3, HEY1, CC10, and FOXJ1 via NKX2-1 Downregulation and Intermittent Hypoxia-Reoxygenation Increases Expression of BMP4, NOT...
Published 2020“…In both the normal and diseased HBE cells, intermittent H/R significantly increased HIF1A, BMP4, NOTCH1, MKI67, OCT4, and MUC5AC expression, while consecutive hypoxia significantly decreased NKX2-1, NOTCH3, HEY1, CC10, and FOXJ1 expression. …”
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655
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656
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657
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658
Discovery of a Colon-Targeted Azo Prodrug of Tofacitinib through the Establishment of Colon-Specific Delivery Systems Constructed by 5‑ASA–PABA–MAC and 5‑ASA–PABA–Diamine for the T...
Published 2022“…Specifically, compound <b>20g</b> displayed a 3.67-fold decrease of plasma AUC<sub>(tofacitinib, 0–∞)</sub> and a 9.61-fold increase of colonic AUC<sub>(tofacitinib, 0–12h)</sub>, compared with tofacitinib at a molar equivalent oral dose. …”
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659
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660