The S-DNA produced in the B-to-S transition does not promote RecA nucleoprotein filament formation. by Hongxia Fu (423266)

“…<p>(A) Time traces of the extension of an 876 bp DNA tether with two GC-rich ends recorded during B-to-S transition in force-increase scan and the reverse S-to-B transition in the subsequent force-decrease scan in 50 mM KCl, 10 mM MgCl₂, pH 7.4, at 24°C. …”

Linaclotide in Chronic Idiopathic Constipation Patients with Moderate to Severe Abdominal Bloating: A Randomized, Controlled Trial by Brian E. Lacy (776932)

“…Approximately one-third of linaclotide patients (each group) had ≥50% mean decrease from baseline in abdominal bloating vs. 18% of placebo patients (<i>P</i><0.01). …”

Identification of genetic interactions with <i>yox1 yhp1</i> mutant strains. by Michelle M. Conti (13514386)

MVEC-EVs promoted OPC survival, proliferation, and motility in a dose-dependent manner. by Masashi Kurachi (106280)

“…(A) The proportion of pyknotic nuclei decreased at doses ≥ 50 μg/ml. …”

Percentage of open AMPA receptors after the release of a single vesicle of glutamate. by Jesus Montes (436513)

Datasheet1_Quality of life, exercise capacity, cognition, and mental health of Chilean patients after COVID-19: an experience of a multidisciplinary rehabilitation program at a phy... by Valeria Paéz (17523354)

Neuropathological findings in a case with Marburg’s variant of MS (case MS-6). by Katsuhisa Masaki (119851)

“…Asterisks indicate vascular lumen (R, S). Scale Bar = 1 mm(A); 500 µm (B, C); 200 µm (D–I); 50 µm (J, K); 100 µm (L, M); 10 µm (N–Q); 20 µm (R); 50 µm (S).…”

Steady state voltage, concentrations and electrochemical potentials for the nanopore in Fig 5a. by Liesbeth van Oeffelen (511929)

“…<p>The values shown are those in a plane through the axis of the nanopore, with <i>V</i>_<i>L</i>−<i>V</i>_<i>R</i> = 0.5 V and a surface charge density of −50mC/m². …”

The expressions of aP2 and LPL mRNA were assessed in mice livers. by Chung-Hwa Park (3637009)

Supplementary Material for: Epidemiology of Transthyretin Familial Amyloid Polyneuropathy in Portugal: A Nationwide Study by Inês M. (5678270)

“…<b><i>Results:</i></b> Over 2010–2016 period, mean incidence rates was 0.87/100,000 (95% CI 0.68–1.10) corresponding to 71 new patients yearly, that has decreased 31% in the last 7 years. …”

<i>In Silico</i> Identification and <i>In Vitro</i> and <i>In Vivo</i> Validation of Anti-Psychotic Drug Fluspirilene as a Potential CDK2 Inhibitor and a Candidate Anti-Cancer Drug by Xi-Nan Shi (765399)

The Efficacy of Hyperbaric Oxygen Therapy on Middle Cerebral Artery Occlusion in Animal Studies: A Meta-Analysis by Yang Xu (178421)

“…Subgroup analysis showed that a maximal neuro-protective effect was reached when HBO was administered immediately after MCAO with an absolute atmospheric pressure (ATA) of 2.0 (50% decrease; 95% CI, 43% -57% decrease; <i>p</i> < 0.0001) and more than 6 hours HBO treatment (53% decrease; 95% CI, 41% -64% decrease; <i>p</i> = 0.0005).…”

The Potential Connectivity of Waterhole Networks and the Effectiveness of a Protected Area under Various Drought Scenarios by Georgina O’Farrill (564895)

“…The Greater Calakmul Region of the Yucatan Peninsula (Mexico) has experienced a 16% decrease in precipitation over the last 50 years, which we hypothesise has affected water resource connectivity. …”

Data_Sheet_1_Variations in the SDN Loop of Class A Beta-Lactamases: A Study of the Molecular Mechanism of BlaC (Mycobacterium tuberculosis) to Alter the Stability and Catalytic Act... by Sourya Bhattacharya (8441028)

“…A significant decrease in melting temperature (BlaC T_M 60°C, S130A T_M 50°C, and S130G T_M 45°C), kinetic instability at higher temperature, and comparative dynamic instability correlate the fact that resistance to beta-lactam/beta-lactamase inhibitor combinations will likely not arise from the structural alteration of BlaC, therefore establishing confidence that this therapeutic modality can be potentially applied as a part of a successful treatment regimen against M. tuberculosis.…”

Data_Sheet_2_Variations in the SDN Loop of Class A Beta-Lactamases: A Study of the Molecular Mechanism of BlaC (Mycobacterium tuberculosis) to Alter the Stability and Catalytic Act... by Sourya Bhattacharya (8441028)

“…A significant decrease in melting temperature (BlaC T_M 60°C, S130A T_M 50°C, and S130G T_M 45°C), kinetic instability at higher temperature, and comparative dynamic instability correlate the fact that resistance to beta-lactam/beta-lactamase inhibitor combinations will likely not arise from the structural alteration of BlaC, therefore establishing confidence that this therapeutic modality can be potentially applied as a part of a successful treatment regimen against M. tuberculosis.…”

TRF1 binding is inhibited by a single nucleotide gap in telomeric DNA by Patricia L. Opresko (7493)

“…Substrates (2.5 nM) were incubated alone (−) or together with decreasing concentrations of TRF1 (200, 100, 50 or 25 nM) (lanes 2–5 and 7–10) for 20 min at 4°C in TEL buffer. …”

A combined loss of PAR-2 and matriptase leads to underdevelopment of placental labyrinth. by Roman Szabo (138655)

“…P values: *<0.05, **<0.01, ***<0.001, Student's t-test, two-tailed. Scale bars: (<b>A, B</b>) 50 µm, (<b>C</b>) 100 um, (<b>D, E, F, H</b>) 200 µm, (<b>G, I</b>) 50 µm.…”

Survival of starvation-induced L1 arrest is a function of RIS activity. by Inka Busack (8474334)

“…B) Strong inactivation significantly decreases survival in L1 arrest whereas strong activation prolongs survival (three-parameter logistic fit, see also <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1010665#pgen.1010665.s012" target="_blank">S1 Table</a>, Fisher’s Exact Test was conducted when 50% of wild-type worms were alive (day 22)). …”

Laboratory selection of <i>Aedes aegypti</i> field populations with the organophosphate malathion: Negative impacts on resistance to deltamethrin and to the organophosphate temepho... by Priscila Fernandes Viana-Medeiros (5729189)

“…In the control groups resistance to all evaluated insecticides decreased except, unexpectedly, to deltamethrin. Analysis of the main resistance mechanisms employed routine methodologies: biochemical and molecular assays for, respectively, metabolic resistance and quantification of the Na_V pyrethroid target main <i>kdr</i> mutations at positions 1016 and 1534. …”

Detection of ENFs in <i>α</i>-GalA KO males frontal paws. by Jarmila Lakomá (152379)

“…Numerical analysis of neuronal fibers terminations showed significant decrease (about 50%; <i>p = 0.0161</i>) in <i>α</i>-GalA KO males in comparison to WT (C).…”