Introducing the 4‑Phenyl-1,2,3-Triazole Moiety as a Versatile Scaffold for the Development of Cytotoxic Ruthenium(II) and Osmium(II) Arene Cyclometalates by Christoph A. Riedl (3593534)

“…Herein we report the synthesis, anticancer potency <i>in vitro</i>, biomolecule interaction, and preliminary mode of action studies of a series of cyclometalated 1,2,3-triazole-derived ruthenium­(II) (<b>2a</b>–<b>e</b>) and osmium­(II) (<b>3a</b>–<b>e</b>) organometallics of the general form [(η⁶-<i>p</i>-cym)­RuCl­(κ²-C^N-L)] with varying substituents in postion 1 of the 1,2,3-triazole moiety. …”

Nrf2-regulated antioxidant protein NQO1 expression is decreased in lung lesions from <i>M. tuberculosis</i> infected guinea pigs. by Gopinath S. Palanisamy (200914)

Culture on rDLL1 decreases the number of single megakaryocytes and increases the size of megakaryocytic colonies generated by CD9^High MEPs. by Michèle Weiss-Gayet (505300)

Trypanocidal Effect of Isotretinoin through the Inhibition of Polyamine and Amino Acid Transporters in <i>Trypanosoma cruzi</i> by Chantal Reigada (3844975)

“…Isotretinoin inhibited the polyamine transport, as well as other amino acid transporters from the same protein family (<i>Tc</i>AAAP), with calculated IC₅₀ values in the range of 4.6–10.3 μM. It also showed a strong inhibition of trypomastigote burst from infected cells, with calculated IC₅₀ of 130 nM (SI = 920) being significantly less effective on the epimastigote stage (IC₅₀ = 30.6 μM). …”

Sagittal joint angles during stance phase at take-off to a jump. by Leena Inkilä (20614460)

<i>neurod1</i>^<i>ΔUCE</i> homozygous mutants display a decrease in the expression of several EE hormones. by Anne Sophie Reuter (12239993)

Reduction of cholesterol levels by MβCD decreased APP localization in lipid rafts from CHO PS1 ΔE9 cells. by Yoon Young Cho (838272)

MiR-99a regulated mTOR/P70/S6K signaling pathway and decreased cell apoptosis in heart of TAC mice. by Qiaoling Li (290816)

“…The expression of mTOR, SMARCA5, SMARCD1 and FGFR3 in heart of TAC mice. C-D. …”

Follistatin expression is decreased and the MAPK signaling pathway is activated in <i>Med1^epi−/−</i> mice keratinocytes <i>in vitro</i>. by Fumihito Noguchi (615295)

Zebrafish eye development disturbed by knockdown of <i>clcc1</i> expression. by Lin Li (28817)

“…<p>Validation: Injection of the 5’-modified EGFP (a) or the unmodified EGFP (d) gave a fluorescent signal (arrowheads). …”

Supplementary Figure S1 - S7 from Dual Src and MEK Inhibition Decreases Ovarian Cancer Growth and Targets Tumor Initiating Stem-Like Cells by Fiona Simpkins (14986536)

Decreased numbers of cells positive for Ki67 and BrdU in nodules of MB allograft treated with AAV-<i>Tis21</i> viral particles. by Dario Presutti (828288)

Patient data. by Alexander Neugebauer (2425123)

“…</p><p>Results</p><p>On average, the time required to move through the obstacle course decreased by 17.0% after the training phase, the number of collisions decreased by 50.0%. …”

Data_Sheet_1_Transcriptome Analysis of Ovarian Follicles Reveals Potential Pivotal Genes Associated With Increased and Decreased Rates of Chicken Egg Production.docx by Xiaoxia Chen (2163943)

The penetration of OU14 but not RACE1 decreased in epidermal cells in which <i>MLO</i> expression was suppressed by transient induced gene silencing (TIGS). by Takashi Yaeno (11320498)

“…Error bars represent standard deviation (n = 5). (<b>b</b>) Penetration rate of OU14 decreased from 7 days after the introduction of MLO-TIGS construct. …”

Decreased accumulation of CD4⁺ T cells and CD19⁺ B cells in DLN of old mice after immunization with ovalbumin. by Justin M. Richner (213025)

Real-time PCR confirmation of selected genes whose expression levels were either increased (red) or decreased (green) by a specific anti-estrogen. by John R. Hawse (227611)

Label-Free Quantitative Proteomic Analysis of Abscisic Acid Effect in Early-Stage Soybean under Flooding by Setsuko Komatsu (422175)

“…The abundance of 34 nuclear proteins such as histone deacetylase and U2 small nuclear ribonucleoprotein increased by ABA supplementation under flooding; however, 35 nuclear proteins such as importin alpha, chromatin remodeling factor, zinc finger protein, transducin, and cell division 5 protein decreased. Of them, the mRNA expression levels of cell division cycle 5 protein, C2H2 zinc finger protein SERRATE, CCCH type zinc finger family protein, and transducin were significantly down-regulated under the ABA treatment. …”

Label-Free Quantitative Proteomic Analysis of Abscisic Acid Effect in Early-Stage Soybean under Flooding by Setsuko Komatsu (422175)

“…The abundance of 34 nuclear proteins such as histone deacetylase and U2 small nuclear ribonucleoprotein increased by ABA supplementation under flooding; however, 35 nuclear proteins such as importin alpha, chromatin remodeling factor, zinc finger protein, transducin, and cell division 5 protein decreased. Of them, the mRNA expression levels of cell division cycle 5 protein, C2H2 zinc finger protein SERRATE, CCCH type zinc finger family protein, and transducin were significantly down-regulated under the ABA treatment. …”

Decreased sperm production in <i>Arf</i>-null mice is compensated by loss of <i>Ink4a</i> or <i>p53</i>. by Michelle L. Churchman (347537)