Prorocentin-5: A Cytotoxic Polyketide from the Benthic Marine Dinoflagellate <i>Prorocentrum lima</i> by Yunseok Choi (5625245)

Subjects:

Conditional ablation of <i>Ybx1</i> leads to a reduction in cortical progenitor cell pool and a decrease in cortical thickness. by Jian Zhang (1682)

Repetitive stress induces a decrease in sound-evoked activity. by Ghattas Bisharat (20706928)

“…Activity rates decreased during repeated stress compared to baseline (2-way ANOVA, condition F = 185.6, <i>p</i> = 4.8 × 10⁻⁴², condition: intensity interaction F = 10.37, <i>p</i> = 9.3 × 10⁻²¹, nested ANOVA (mouse nested within session), condition F = 174, <i>p</i> = 1.5 × 10⁻³⁹, condition: intensity interaction F = 12.7, <i>p</i> = 2 × 10⁻²⁶, post hoc for each level baseline versus repetitive stress <i>p</i> < 0.01 for all levels above 50 dB, all Bonferroni corrected). …”

Knockdown of MRN complex decreases HBV cccDNA level. by Kaitao Zhao (3617825)

Knockdown of MRN complex decreases HBV cccDNA level. by Kaitao Zhao (3617825)

Pairwise correlations in APP/PS1 mice are decreased in dCA1, but increased in vCA1. by Udaysankar Chockanathan (18510288)

Juvenile demyelination leads to a substantial decrease in potassium currents in PV interneurons of the PFC. by Sara Hijazi (21656615)

“…Scale: 500 pA, 100 ms. <b>B</b>. I–V curves showing a significant decrease in Kv amplitude in PV interneurons from mice that underwent juvenile demyelination. …”

Impaired Ubr5 function results in increased canonical and decreased non-canonical HH signalling. by David Mellis (2833469)

Population dynamics modeling of split^50cM <i>ClvR</i> V1 introduced at a 50% release, with fitness cost per allele varying from 0–15%. by Georg Oberhofer (3401438)

Antagonist dosage and occupancy for each 5-HT receptor subtype. by Yukiko Hori (299784)

Subjects:

HPD 1466 decreases empty capsid accumulation in cells replicating HBV. by Daniel P. Bradley (10306893)

GSK343 decreased tumor stemness. by Laura V. Bownes (10276762)

“…(C) COA6 cells were treated with GSK343 (0, 5 μM) for 72 hours. qPCR demonstrated a significant decrease in mRNA abundance of known stemness markers Oct4, Nanog, and Sox2 following GSK343 treatment compared to untreated cells. …”

Longer polyQ sequences decrease the nuclear localization of AR in the absence of hormone. by Carlos M. Roggero (11909585)

Video_5_Contribution of 5-HT2 Receptors to the Control of the Spinal Locomotor System in Intact Rats.WMV by Henryk Majczyński (830716)

“…Little is known about the role of 5-HT receptors in the control of voluntary locomotion, so we administered inverse agonists of 5-HT₂ (Cyproheptadine; Cypr), 5-HT_2A neutral antagonist (Volinanserin; Volin), 5-HT_2C neutral antagonist (SB 242084), and 5-HT_2B/2C inverse agonist (SB 206553) receptors intrathecally in intact rats and monitored their effects on unrestrained locomotion. …”

Additional Analysis of visually induced calcium transients in Fig 6. by Maureen M. Sampson (9322886)

“…<p>Visually induced calcium transients were recorded in 5-HT2B +/- or 5-HT2B -/- flies as described in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1009003#pgen.1009003.g006" target="_blank">Fig 6</a>. …”

Serotonin modulates L2 neuron visually induced calcium transient kinetics. by Maureen M. Sampson (9322886)

“…Comparisons are two-way repeated measures ANOVA with the bracket in 5C’ indicating a significant effect of genotype (p≤0.05*).…”

Simulations that now also include an <i>asymmetric</i> indoors/outdoors model, with a threshold temperature of 17.5C in spring, and 25C in fall. by Sebastian A. Müller (10688740)

Transcriptional and translational markers of syncytialization and biochemical differentiation are significantly decreased by rotenone. by O’Llenecia S. Walker (8486163)

ST2-104 decreases the Aβ_25-35-mediated increase in intracellular Ca²⁺. by Yingshi Ji (9013004)

Design, Synthesis, and Biological Evaluation of New Peripheral 5HT_2A Antagonists for Nonalcoholic Fatty Liver Disease by Minhee Kim (1592440)

“…Recent findings suggest that peripheral serotonin (5-hydroxytryptamine, 5HT) regulates energy homeostasis, including hepatic lipid metabolism. …”