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The rate of lariat formation is decreased two-fold by isoginkgetin treatment.
Published 2014“…The indicated values are from an average of three biological replicates, and <i>p</i>-values are from two-tailed <i>t</i>-tests based on mean values for aggregated introns 2–10 (n = 9). (<b>C</b>) Isoginkgetin treatment leads to a decreased rate of lariat formation (* indicates <i>p</i> = 0.02) without affecting exon ligation or excised lariat degradation (<i>p</i> = 0.22, 0.08), with calculations as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0089673#pone-0089673-g001" target="_blank">Fig. 1</a>. …”
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Beta-catenin signaling is decreased in intermediate progenitor cells.
Published 2010“…Scale bars are 50 µm. * * = P<0.001, t test, two-tailed. (<b>C</b>) To further quantify signaling differences between Tbr2+ and Tbr2- cells, dorsolateral neocortices from E13.5 Eomes::GFP embryos (n = 3) were FACS sorted for GFP+ and GFP- cells (see cartoon). mRNA from these cells was isolated and reverse transcribed into cDNA for real-time PCR analysis. …”
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Mesothelin expression and RG7787 uptake is decreased in KLM-1-R.
Published 2015“…<p><b>A</b>: Surface mesothelin levels are 5-fold lower in resistant KLM-1 (KLM-1-R) compared to KLM-1. …”
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TUDCA decreases ER stress in HOX neonatal rat lungs.
Published 2022“…<p>(<b>A</b>) The expression levels of ER stress markers (P-PERK 0.6±0.1-fold, p<0.001, n = 5; PERK 0.7±0.1-fold, p = 0.00364, n = 5; P-IRE1α 0.6±0.0-fold, p<0.001, n = 5; IRE1α 0.6±0.1-fold, p<0.001, n = 5; GRP78 0.8±0.1-fold, p<0.001, n = 5; cleaved ATF6 0.1±0.0-fold, p<0.001, n = 5; spliced XBP1 0.3±0.0-fold, p<0.001, n = 5; 2 males and 3 females) are all decreased while the N-glycosylated VEGFR2 is increased (3.5±0.2-fold, p<0.001, n = 5) in HOX neonatal lungs at P10 indicating TUDCA can attenuate hyperoxia-induced ER stress. …”
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