A Top-Down Proteomics Platform Coupling Serial Size Exclusion Chromatography and Fourier Transform Ion Cyclotron Resonance Mass Spectrometry by Trisha Tucholski (3992264)

“…Notably, within a 5 <i>m</i>/<i>z</i> window, we obtained baseline isotopic resolution for 6 distinct large proteoforms (30–50 kDa). …”

DataSheet5_Peripheral proteomic changes after electroconvulsive seizures in a rodent model of non-response to chronic fluoxetine.pdf by Rodolphe H. Lebeau (14031246)

“…A 50% decrease in emotionality score threshold before and after Flx, was used to separate Flx-responding mice (Flx-R, n = 18), or Flx non-responder mice (Flx-NR, n = 7). …”

DataSheet3_Peripheral proteomic changes after electroconvulsive seizures in a rodent model of non-response to chronic fluoxetine.PDF by Rodolphe H. Lebeau (14031246)

“…A 50% decrease in emotionality score threshold before and after Flx, was used to separate Flx-responding mice (Flx-R, n = 18), or Flx non-responder mice (Flx-NR, n = 7). …”

The prevalence of cardiovascular autonomic neuropathy and its influence on post induction hemodynamic variables in patients with and without diabetes; A prospective cohort study by Jorinde A. W. Polderman (6009083)

“…Primary outcomes were the prevalence of CAN and the relation between CAN and severe post-induction hypotension, defined as mean arterial pressure (MAP) < 50 mmHg or ≥ 50% decrease from baseline. Secondary outcomes were the relation between CAN, intraoperative hypotension, MAP < 65 mmHg for more than 13 minutes, and the use of vasopressor therapy.…”

DataSheet2_Peripheral proteomic changes after electroconvulsive seizures in a rodent model of non-response to chronic fluoxetine.PDF by Rodolphe H. Lebeau (14031246)

“…A 50% decrease in emotionality score threshold before and after Flx, was used to separate Flx-responding mice (Flx-R, n = 18), or Flx non-responder mice (Flx-NR, n = 7). …”

Table2_Effectiveness and Safety of Iguratimod Monotherapy or Combined With Methotrexate in Treating Rheumatoid Arthritis: A Systematic Review and Meta-Analysis.DOCX by Dan Ouyang (554436)

“…Pooled results demonstrated as follows: 1) Compared with methotrexate (MTX) alone, IGU alone was superior in improving ACR20 and DAS28-ESR, while having no significant difference in ACR50 and ACR70 [ACR20: (RR 1.15, 95% CI 1.05–1.27, p = 0.004); ACR50: (RR 0.97, 95% CI 0.66–1.44, p = 0.88); ACR70: (RR 0.92, 95% CI 0.45–1.90, p = 0.83); DAS28-ESR: mean difference (MD) −0.15, 95% CI −0.27 to −0.03, p = 0.01]. 2) Compared with MTX alone, IGU + MTX was more effective in improving ACR20, ACR50, ACR70, and DAS28-ESR. …”

Metformin requires transcription factor SKN-1 to increase median lifespan, via a mechanism that acts in both ASI neurons and the intestine. by Brian Onken (86790)

“…Pooled data for <i>skn-1(zu135)</i> mutants expressing <i>skn-1::gfp</i> only in the ASI neurons show a median lifespan decrease from 16 days for animals on 0 mM metformin to 13 days for animals on 50 mM metformin, with a significantly left-shifted survival curve (<i>P</i><0.0001 by the Log-rank test, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0008758#pone.0008758.s005" target="_blank">Table S1G</a>). …”

Galunisertib (LY2157299), a transforming growth factor-β receptor I kinase inhibitor, attenuates acute pancreatitis in rats by X. Liu (589632)

“…<div><p>Galunisertib (LY2157299), a selective ATP-mimetic inhibitor of TGF-β receptor I (TGF-βRI), is the only known TGF-β pathway inhibitor. …”

DataSheet_1_A first-in-human, open-label, dose-escalation and dose-expansion phase I study to evaluate the safety, tolerability, pharmacokinetics/pharmacodynamics, and antitumor ac... by Zhiyu Huang (638377)

“…Background<p>QL1604 is a humanized immunoglobulin G4 monoclonal antibody against programmed cell death protein 1. …”

The correlation between the abundance of exotic plant species and native vertebrate species within a forest area near York University Keele campus. by mohamed Abdulrahim osman (3115932)

“…At the tip of the 50 meters line a radius of 50 meters was calculated. …”

Evidence of local mechanical control for bone formation and resorption. by Friederike A. Schulte (406501)

“…(D) Mechanical regulation in the CTR group. (E) Sagittal sections through CV6 at (bottom) 0 and (top) 12 weeks after ovariectomy (OVX) (F) OVX causes a strong decrease in BV/TV compared to SHAM-operation (SHM). …”

A Randomized Controlled Study on the Effects of Bisoprolol and Atenolol on Sympathetic Nervous Activity and Central Aortic Pressure in Patients with Essential Hypertension by Wei-Jun Zhou (456887)

“…</p><p>Methods</p><p>This was a prospective, randomized, controlled study in 109 never-treated hypertensive subjects randomized to bisoprolol (5 mg) or atenolol (50 mg) for 4–8 weeks. …”

Hedgehog Signaling Antagonist Promotes Regression of Both Liver Fibrosis and Hepatocellular Carcinoma in a Murine Model of Primary Liver Cancer by George M. Philips (206900)

“…Hepatocellular carcinoma (HCC) emerges spontaneously in such mice by 50–60 weeks of age, providing a model of fibrosis-associated hepatocarcinogenesis. …”

Table 1_Evaluating the prognostic relevance of neutrophil-to-lymphocyte ratio in cervical cancer: a systematic review and meta-analysis.docx by Xieyan Zhuang (20467625)

“…Furthermore, elevated NLR significantly impacted disease-free survival (HR: 1.79, 95% CI: 1.18-2.71; p = 0.006), recurrence rates (HR: 2.18, 95% CI: 1.36-3.51; p = 0.001), recurrence-free survival (HR: 3.05, 95% CI: 1.79-5.19; p < 0.0001), and the incidence of distant metastases (HR: 1.73, 95% CI: 1.20-2.50; p = 0.003).</p>Conclusion<p>An elevated NLR prior to treatment demonstrates a strong association with decreased OS and PFS among patients with cervical cancer, underscoring the significance of NLR as a prognostic marker within this population.…”

1,3,2-Dioxathiolane 2,2-Dioxide as a Bifunctional Electrolyte Additive to Enhance the Stability of Lithium Metal Anodes by Yi-Xin Huang (7405004)

“…In this work, we report on a new approach utilizing 1,3,2-dioxathiolane 2,2-dioxide (DTD) additives in electrolytes to enhance the performance of LMBs. …”

Data_Sheet_2_Effect of Levothyroxine on Blood Pressure in Patients With Subclinical Hypothyroidism: A Systematic Review and Meta-Analysis.doc by Weiwei He (32469)

“…Meta-analysis of the 19 prospective follow-up studies found that LT4 therapy significantly decreased SBP and DBP by 4.80 mmHg (95%CI −6.50 to −3.09, P < 0.001) and 2.74 mmHg (95%CI −4.06 to −1.43, P < 0.001), respectively.…”

Poly(caprolactone)-Based Coatings on 3D-Printed Biodegradable Implants: A Novel Strategy to Prolong Delivery of Hydrophilic Drugs by Sarah A. Stewart (9198984)

“…Implants could be specifically developed in order to match the specific release rate required for a number of drugs for a wide range of conditions.…”

Data_Sheet_1_Association of plasma propionate concentration with coronary artery disease in a large cross-sectional study.PDF by Nikolaos Pagonas (306007)

“…</p>Results<p>The study included 1,253 patients (median [IQR], 67 [58–76] years; 799 men [64%]). A total of 739 had invasively confirmed CAD with at least one coronary artery stenosis ≥50% and 514 had exclusion of CAD. …”

1,3,2-Dioxathiolane 2,2-Dioxide as a Bifunctional Electrolyte Additive to Enhance the Stability of Lithium Metal Anodes by Yi-Xin Huang (7405004)

“…In this work, we report on a new approach utilizing 1,3,2-dioxathiolane 2,2-dioxide (DTD) additives in electrolytes to enhance the performance of LMBs. …”

Dental developmental complications in pediatric hematopoietic stem cell transplantation patients: A study using CMC clinical data warehouse by Jaehyun Kim (14009967)

“…Regression analysis demonstrated that a younger age at initial chemotherapy was a risk factor for tooth agenesis and microdontia.  …”