<i>Bmp6</i> Expression Can Be Regulated Independently of Liver Iron in Mice by Zhuzhen Zhang (311660)

“…Furthermore, we also confirmed previous suggestions that Tf-bound iron regulates <i>Hamp1</i> expression via Smad1/5/8 phosphorylation without affecting <i>Bmp6</i> expression, and the effect of Tf-bound iron on <i>Hamp1</i> regulation appeared before a significant change in <i>Bmp6</i> expression. …”

Image_1_Tumor Cell-Based Vaccine Generated With High Hydrostatic Pressure Synergizes With Radiotherapy by Generating a Favorable Anti-tumor Immune Microenvironment.TIF by Christoph Seitz (762554)

“…In B16-F10 tumors that were irradiated with 2 × 5Gy and vaccinated once with HHP-killed tumor cells, the amount of natural killer (NK) cells, monocytes/macrophages, CD4+ T cells and NKT cells was significantly increased, while the amount of B cells was significantly decreased. …”

Impact of Transcatheter Aortic Valve Implantation on Kidney Function by Rita Calça (7888694)

“…We analyzed the eGFR one month and one year after TAVI in these three groups, using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula to calculate it. …”

Data_Sheet_1_Deep Learning Convolutional Neural Networks Discriminate Adult ADHD From Healthy Individuals on the Basis of Event-Related Spectral EEG.PDF by Laura Dubreuil-Vall (8691447)

“…Finally, through the use of feature visualization techniques such as DeepDream, we show that the main features exciting the CNN nodes are a decreased power in the alpha band and an increased power in the delta-theta band around 100 ms for ADHD patients compared to healthy controls, suggestive of attentional and inhibition deficits, which have been previously suggested as pathophyisiological signatures of ADHD. …”

Controlling the Rigidity of Kinesin-Propelled Microtubules in an <i>In Vitro</i> Gliding Assay Using the Deep-Sea Osmolyte Trimethylamine <i>N</i>‑Oxide by Arif Md. Rashedul Kabir (7513523)

“…Based on this strategy, we are able to reduce the persistence length of microtubules, a measure of microtubule rigidity, ∼8 fold by using TMAO at the concentration of 1.5 M. …”

Idraparinux or Idrabiotaparinux for Long-Term Venous Thromboembolism Treatment: A Systematic Review and Meta-Analysis of Randomized Controlled Trials by Yanzhi Song (487706)

“…We used the fixed effect model to analyze the safety outcomes and demonstrated that idraparinux or idrabiotaparinux decreased major bleeding rate significantly (RR 0.73, 95% CI 0.54 to 0.98, P = 0.04) but had a trend to increase the all cause mortality (RR 1.26, 95% CI 1.00 to 1.57, P = 0.05) compared with warfarin.…”

Table_2_A novel form of transcutaneous electrical nerve stimulation for the reduction of dysesthesias caused by spinal nerve dysfunction: A case series.docx by Yuki Nishi (7486787)

“…Background<p>Current therapeutic interventions for dysesthesias caused by spinal cord dysfunctions are ineffective. We propose a novel intervention using transcutaneous electrical nerve stimulation (TENS) for dysesthesias, and we present an in-depth case series.…”

DataSheet_3_Increased Expression of Mitochondrial UQCRC1 in Pancreatic Cancer Impairs Antitumor Immunity of Natural Killer Cells via Elevating Extracellular ATP.docx by Hui Cong (3909211)

“…Such UQCRC1-induced impairment of NK cells was mediated by eATP and its metabolite adenosine via P2Y11R and A_2AR, respectively. Mechanistically, we found the UQCRC1/eATP axis reduced the expression of chemokine CCL5 in cancer cells and altered the balance of activating receptor DNAM-1 and inhibitory receptor CD96 on NK-92MI cells, resulting in decreased chemotaxis and exhausted phenotype of NK-92MI cells. …”

Impact of Transcatheter Aortic Valve Implantation on Kidney Function by Rita Calça (7888694)

“…We analyzed the eGFR one month and one year after TAVI in these three groups, using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula to calculate it. …”

Table_3_A novel form of transcutaneous electrical nerve stimulation for the reduction of dysesthesias caused by spinal nerve dysfunction: A case series.docx by Yuki Nishi (7486787)

“…Background<p>Current therapeutic interventions for dysesthesias caused by spinal cord dysfunctions are ineffective. We propose a novel intervention using transcutaneous electrical nerve stimulation (TENS) for dysesthesias, and we present an in-depth case series.…”

Data_Sheet_2_A Phosphoproteomics Study of the Soybean root necrosis 1 Mutant Revealed Type II Metacaspases Involved in Cell Death Pathway.docx by Feifei Wang (195514)

“…We identified 3,160 proteins. When the p-value was set at ≤0.05 and the fold change of protein accumulation between rn1 and T322 at ≥1.5 or ≤0.67, we detected 118 proteins that showed increased levels and 32 proteins decreased levels in rn1 as compared to that in T322. …”

Functional Trait Strategies of Trees in Dry and Wet Tropical Forests Are Similar but Differ in Their Consequences for Succession by Madelon Lohbeck (731258)

“…Species turnover with succession in dry forest largely relates to increasing water availability and in wet forest to decreasing light availability. We hypothesized that while functional trait trade-offs are similar in the two forest systems, the successful plant strategies in these communities will be different, as contrasting filters affect species turnover. …”

Dissecting <em>Phaseolus vulgaris</em> Innate Immune System against <em>Colletotrichum lindemuthianum</em> Infection by Paula Rodrigues Oblessuc (141400)

“…Based on experimental validation of gene expression, we propose that hypersensitive reaction as part of effector-triggered immunity may operate, at least in part, by down-regulating genes, such as <em>FLS2-like</em> and <em>MKK5-like</em>, putative orthologs of the Arabidopsis genes involved in pathogen perception and downstream signaling.…”

DataSheet_1_Soluble CD83 modulates human-monocyte-derived macrophages toward alternative phenotype, function, and metabolism.docx by Katrin Peckert-Maier (13211658)

“…We show that sCD83 strikingly increases the expression of inhibitory molecules including ILT-2 (immunoglobulin-like transcript 2), ILT-4, ILT-5, and CD163, whereas activation markers, such as MHC-II and MSR-1, were significantly downregulated. …”

Senescence Is More Important in the Natural Lives of Long- Than Short-Lived Mammals by Christopher Turbill (244271)

“…The slope of this relationship (0.353±0.052 s.e.m.), however, indicated that mammals with higher survival rates have a mean life span representing a greater fraction of their potential maximum life span: the ratio of maximum to mean life span decreased significantly from >10 in short-lived to ∼1.5 in long-lived mammal species.…”

Targeted Resequencing of the Pericentromere of Chromosome 2 Linked to Constitutional Delay of Growth and Puberty by Diana L. Cousminer (747917)

“…One gene, <i>DNAH6</i>, harbored 6 protein-altering low-frequency variants (< 6% in the Finnish population) in 10 of the CDGP probands. We sequenced an additional 135 unrelated Finnish CDGP subjects and utilized the unique Sequencing Initiative Suomi (SISu) population reference exome set to show that while 5 of these variants were present in the CDGP set, they were also present in the Finnish population at similar frequencies. …”

Presentation_1.pdf by Behzad Bidadi (4953235)

“…<p>Neutropenia secondary to chemotherapy in breast cancer patients can be life-threatening and there are no biomarkers available to predict the risk of drug-induced neutropenia in those patients. We previously performed a genome-wide association study (GWAS) for neutropenia events in women with breast cancer who were treated with 5-fluorouracil, epirubicin and cyclophosphamide and recruited to the SUCCESS-A trial. …”

DataSheet_1_Increased Expression of Mitochondrial UQCRC1 in Pancreatic Cancer Impairs Antitumor Immunity of Natural Killer Cells via Elevating Extracellular ATP.docx by Hui Cong (3909211)

“…Such UQCRC1-induced impairment of NK cells was mediated by eATP and its metabolite adenosine via P2Y11R and A_2AR, respectively. Mechanistically, we found the UQCRC1/eATP axis reduced the expression of chemokine CCL5 in cancer cells and altered the balance of activating receptor DNAM-1 and inhibitory receptor CD96 on NK-92MI cells, resulting in decreased chemotaxis and exhausted phenotype of NK-92MI cells. …”

Table_1_Mendelian randomization in blood metabolites identifies triglycerides and fatty acids saturation level as associated traits linked to pancreatitis risk.xlsx by Jiarui Mi (11170284)

“…Next, we exploited the MR-BMA method to pinpoint the dominating factors on the increased risk of pancreatitis.…”

Data_Sheet_1_Involvement of Gut Microbiota in the Development of Psoriasis Vulgaris.doc by Chaonan Sun (4681345)

“…Accumulating observations show gut microbiota dysbiosis in psoriasis. We intend to further investigate the relationship between intestinal microbiota and psoriasis development.…”