Functional Implications of Novel Human Acid Sphingomyelinase Splice Variants by Cosima Rhein (168205)

“…</p> <h3>Methodology/Principal Findings</h3><p>We identified three novel ASM splice variants in human cells, termed ASM-5, -6 and -7, which lack portions of the catalytic- and/or carboxy-terminal domains in comparison to full-length ASM-1. …”

Maximal long-term growth rate depends on the frequency of signals and stress. by Markus Arnoldini (141879)

“…The probability for a signal, , is 0.5. Cost parameters used are , for both plots.</p>…”

<b>Morin alleviates fructose-driven disturbance of podocyte mitochondrial energy metabolism by inhibiting AMPD activity to improve glomerular injury</b> by Luyi Huang (22583081)

“…<p dir="ltr">High consumption of fructose is a significant risk factor for glomerular podocyte injury. We reported a novel mechanism that high fructose increased the activity of adenosine 5’-monophosphate deaminase (AMPD) in the purine nucleotide cycle (PNC), which contributed to mitochondrial dysfunction and activated glycolysis in podocyte injury. …”

Data_Sheet_2_Rewiring of Gene Expression in Pseudomonas aeruginosa During Diauxic Growth Reveals an Indirect Regulation of the MexGHI-OpmD Efflux Pump by Hfq.pdf by Marlena Rozner (12911555)

“…As Hfq function is impeded by the RNA CrcZ upon relief of CCR, and Hfq is known to impact antibiotic susceptibility in P. aeruginosa, emphasis was laid on links between CCR and antibiotic susceptibility. To this end, we show that the mexGHI-opmD operon encoding an efflux pump for the antibiotic norfloxacin and the virulence factor 5-Methyl-phenazine is upregulated after alleviation of CCR, resulting in a decreased susceptibility to the antibiotic norfloxacin. …”

Image_2_Mutation in the 26S proteasome regulatory subunit rpn2 gene in Plasmodium falciparum confers resistance to artemisinin.pdf by Adriana F. Gonçalves (17937905)

“…Plasmids carrying a functional rpn2 interspecies chimeric gene with 5’ recombination region from P. falciparum and 3’ from P. chabaudi were constructed and transfected into Dd2 P. falciparum parasites.…”

Optimum temperature may be a misleading parameter in enzyme characterization and application by Vitor M. Almeida (4768668)

“…A search in the PubMed database for “optimum temperature” and “enzymes” yielded more than 1,700 manuscripts reporting this parameter over the last five years. Here, we show that the optimum temperature is not a constant. …”

Application of Multichannel Collagen Gels in Construction of Epithelial Lumen-like Engineered Tissues by Kazuya Furusawa (1569568)

Glasslike Membrane Protein Diffusion in a Crowded Membrane by Ignacio Munguira (1434316)

A Multiscale Survival Process for Modeling Human Activity Patterns - Fig 1 by Tianyang Zhang (2588194)

“…The red line shows the threshold statistic to pass the KS test with the significance level of 5%, which gradually increases due to the decreased amount of data.…”

Application of Multichannel Collagen Gels in Construction of Epithelial Lumen-like Engineered Tissues by Kazuya Furusawa (1569568)

Data_Sheet_1_Rewiring of Gene Expression in Pseudomonas aeruginosa During Diauxic Growth Reveals an Indirect Regulation of the MexGHI-OpmD Efflux Pump by Hfq.xlsx by Marlena Rozner (12911555)

“…As Hfq function is impeded by the RNA CrcZ upon relief of CCR, and Hfq is known to impact antibiotic susceptibility in P. aeruginosa, emphasis was laid on links between CCR and antibiotic susceptibility. To this end, we show that the mexGHI-opmD operon encoding an efflux pump for the antibiotic norfloxacin and the virulence factor 5-Methyl-phenazine is upregulated after alleviation of CCR, resulting in a decreased susceptibility to the antibiotic norfloxacin. …”

Data_Sheet_1_Rewiring of Gene Expression in Pseudomonas aeruginosa During Diauxic Growth Reveals an Indirect Regulation of the MexGHI-OpmD Efflux Pump by Hfq.xlsx by Marlena Rozner (12911555)

“…As Hfq function is impeded by the RNA CrcZ upon relief of CCR, and Hfq is known to impact antibiotic susceptibility in P. aeruginosa, emphasis was laid on links between CCR and antibiotic susceptibility. To this end, we show that the mexGHI-opmD operon encoding an efflux pump for the antibiotic norfloxacin and the virulence factor 5-Methyl-phenazine is upregulated after alleviation of CCR, resulting in a decreased susceptibility to the antibiotic norfloxacin. …”

Successful restoration of knee extension after transferring of the anterior branch of the obturator nerve: a case study by Mohammadreza Emamhadi (10176503)

“…</p> <p><b>Methods:</b> We describe a 27-year-old male who had quadriceps femoris muscle paralysis after surgical evacuation for retroperitoneal hematoma five months ago. …”

Glasslike Membrane Protein Diffusion in a Crowded Membrane by Ignacio Munguira (1434316)

Error budget for the peak energy of all the spectral profiles of Ti Kβ that go into the final energy determination by C T Chantler (557430)

“…The peak energy of the titanium Kβ spectral profile is found to be 4931.966 ± 0.022 eV prior to instrumental broadening. This 4.5 ppm result decreases the uncertainty over the past literature by a factor of 2.6 and is 2.4 standard deviations from the previous standard. …”

Docking of LDCVs Is Modulated by Lower Intracellular [Ca²⁺] than Priming by Mathias Pasche (74950)

“…The parameters that reflect docking, i.e. axial mobility and the fraction of LDCVs residing at the plasma membrane for less than 5 seconds, were strongly decreased at a free [Ca²⁺]_i of 500 nM. …”

Reconciling a Kinetic Model for Dimerization of the EGFR Using Single-Molecule Tracking in Living Cells by Kiwook Kim (756439)

High-Throughput Identification of Chemical Inhibitors of <em>E. coli</em> Group 2 Capsule Biogenesis as Anti-Virulence Agents by Carlos C. Goller (245570)

“…Components of assembly and export are highly conserved among the major K antigen capsular types associated with UTI-causing <em>E. coli</em> and are distinct from the capsule biogenesis machinery of many commensal <em>E. coli</em>, making these attractive therapeutic targets. We conducted a screen for anti-capsular small molecules and identified an agent designated “C7” that blocks the production of K1 and K5 capsules, unrelated polysaccharide types among the Group 2–3 capsules. …”

Data_Sheet_2_Rewiring of Gene Expression in Pseudomonas aeruginosa During Diauxic Growth Reveals an Indirect Regulation of the MexGHI-OpmD Efflux Pump by Hfq.pdf by Marlena Rozner (12911555)

“…As Hfq function is impeded by the RNA CrcZ upon relief of CCR, and Hfq is known to impact antibiotic susceptibility in P. aeruginosa, emphasis was laid on links between CCR and antibiotic susceptibility. To this end, we show that the mexGHI-opmD operon encoding an efflux pump for the antibiotic norfloxacin and the virulence factor 5-Methyl-phenazine is upregulated after alleviation of CCR, resulting in a decreased susceptibility to the antibiotic norfloxacin. …”

DataSheet1_Deficiencies in the Recognition and Reporting of Chronic Kidney Disease in Patients With Type 2 Diabetes Mellitus; A Hungarian Nationwide Analysis.PDF by Erzsébet Ladányi (16897194)

“…The annual incidence of T2DM and incidence rates of CKD in T2DM decreased in 2017–2020 (p < 0.001). The annual prevalence of T2DM increased (p < 0.01), the prevalence rates of CKD in T2DM were low and decreased from 9.8% to 6.5% in 2016–2020 (p < 0.001).…”