Selective TASK‑1 Inhibitor with a Defined Structure–Activity Relationship Reduces Cancer Cell Proliferation and Viability by Bárbara Arévalo (4053358)

“…Mutation of seven residues to A (I118A, L122A, F125A, Q126A, L232A, I235A, and L239A) markedly decreased the F3-induced inhibition of TASK-1 channels, consistent with the molecular modeling predictions. …”

Selective TASK‑1 Inhibitor with a Defined Structure–Activity Relationship Reduces Cancer Cell Proliferation and Viability by Bárbara Arévalo (4053358)

“…Mutation of seven residues to A (I118A, L122A, F125A, Q126A, L232A, I235A, and L239A) markedly decreased the F3-induced inhibition of TASK-1 channels, consistent with the molecular modeling predictions. …”

Klf5 down-regulation leads to human VSMC senescence. by Dong Ma (584680)

Triiodothyroacetic acid (TRIAC), thyroxine (T4) and 3,5,3’-triiodothyronine (T3) levels in plasma of vehicle treated wild type (Wt; TRIAC n = 5; T4 n = 5; T3 n = 5 and TSH n = 4) a... by Soledad Bárez-López (607514)

HEWL interacts with dissipated oleic acid micelles, and decreases oleic acid cytotoxicity by Qin Huang (49441)

Growth curves (A, strain AWRI R2 (A); B, strain BH8 (B); C, strain Freddo (F)) and accumulated fermentation system mass loss(D, strain A; E, strain B; F, strain F) of <i>S</i>. <i>... by Xiang-yu Sun (748032)

Increased expression of Fz5 receptor matched with a decrease in NeuN immunoreactivity at 16w. by Carlos González-Fernández (2794207)

Genetic deletion of Bin1 in neurons leads to a reduction in survival but not to neuronal loss in PS19 Hemi or Ncar mice. by Kathleen M. McAvoy (7224863)

Fig 5 - by Mykola Pinkevych (125551)

The effects of GM-CSF on DMN-induced histopathological changes. by Mrigendra Bir Karmacharya (13607415)

Schematic representation of the effects of stepwise bromination of the benzene ring of benzotriazole (Bt), including interdependence of the molecular volume (A) and pK_a (B) of the products with their IC₅₀ for inhibition of protein kinase CK2α: (a) Green arrows follow sequential bromination of the central vicinal C(5)/C(6) atoms, leading to a moderate decrease of pK_a and a large decrease in IC₅₀; (b) Red arrows illustrate the lesser effects of bromination of the peripheral C(4)/C(7) atoms, resulting in a significant decrease of pK_a, with virtually no gain in inhibitory activity; (c) Black lines link products with the same number of bromine atoms, but substantially differing in pK_a and IC₅₀, culminating in the di- and tri-brominated derivatives with inhibitory activities comparable to that of TBBt. by Romualda Wąsik (119538)

Effects of GM-CSF on the DMN-induced inhibition of PPAR-γ expression. by Mrigendra Bir Karmacharya (13607415)

Effects of GM-CSF on DMN-induced TGF-β1 expression. by Mrigendra Bir Karmacharya (13607415)

Western blot analysis of collagen type I, α-SMA, and TGF-β1 in liver. by Mrigendra Bir Karmacharya (13607415)

Effects of GM-CSF on DMN-induced hepatotoxicity. by Mrigendra Bir Karmacharya (13607415)

Effects of GM-CSF on DMN-induced changes in survival and body weights. by Mrigendra Bir Karmacharya (13607415)

Tendency chart of monthly FVC mean. by Yichuan Zhang (2888345)

“…<div><p>The study on the spatial distribution and dynamic change in monthly Fractional Vegetation Cover (FVC) of parks provides a scientific basis for vegetation management and optimization in urban parks. …”

Fig 7 - by Finn Egil Skjeldestad (7821716)

Subjects:

Effects of specific anti-miRs for the five miRNAss on the IC50 of cisplatin (A) and paclitaxel (B) in Hec1A cells. by Taek Sang Lee (494682)

Ulk2 morphants have a decreased extension/retraction ratio. by Stacey Lee (647217)