Creation of a <i>lacIZYA</i> operon fusion to assess the levels of gene expression from the <i>lacI</i> gene promoter. by Alasdair J. E. Gordon (427822)

Data_Sheet_1_Effect of exercise on cognitive function and synaptic plasticity in Alzheimer's disease models: A systematic review and meta-analysis.zip by Linlin Guo (551808)

“…Compared with controls, exercise decreased escape latency (SMD = −0.86, 95% CI: −1.21 to −0.50, P < 0.001), increased platform crossover numbers (SMD = 1.34, 95% CI: 0.57–2.11, P = 0.001) and time in the target quadrant (SMD = 1.65, 95% CI: 0.95–2.36, P < 0.001) and the expression of PSD95 (SMD = 0.73, 95% CI: 0.25–1.21, P = 0.003) in AD animals. …”

DataSheet_1_Case report: Excessive daytime sleepiness as a presenting manifestation of autoimmune glial fibrillary acidic protein astrocytopathy.pdf by Mingyang Tang (13798123)

“…Our patient was a 58-year-old male who experienced excessive daytime sleepiness for 50 days following SARS-CoV-2 infection. …”

Table1_Uncovering the clinical relevance of unclassified variants in DNA repair genes: a focus on BRCA negative Tunisian cancer families.xlsx by Maroua Boujemaa (5350577)

“…Family segregation analysis was also performed.</p><p>Results: Among a total of 37 VUSs identified, 11 variants are likely deleterious affecting ATM, BLM, CHEK2, ERCC3, FANCC, FANCG, MSH2, PMS2 and RAD50 genes. …”

A Selective HDAC 1/2 Inhibitor Modulates Chromatin and Gene Expression in Brain and Alters Mouse Behavior in Two Mood-Related Tests by Frederick A. Schroeder (445653)

“…Pharmacotherapy, the primary – albeit often ineffective – treatment method, has remained largely unchanged over the past 50 years, highlighting the need for novel target discovery and improved mechanism-based treatments. …”

Unilateral electrical stimulation of the heart 7 acupuncture point to prevent emergence agitation in children: A prospective, double-blinded, randomized clinical trial by Nobuhito Nakamura (3005613)

“…Previously, our group reported that stimulating the heart 7 (HT7) acupuncture point bilaterally using two neuromuscular transmission monitoring devices (NTMs) decreased the incidence of EA. However, bilateral stimulation is a barrier to clinical use because two NTMs are needed for one patient.…”

Image1_Uncovering the clinical relevance of unclassified variants in DNA repair genes: a focus on BRCA negative Tunisian cancer families.pdf by Maroua Boujemaa (5350577)

“…Family segregation analysis was also performed.</p><p>Results: Among a total of 37 VUSs identified, 11 variants are likely deleterious affecting ATM, BLM, CHEK2, ERCC3, FANCC, FANCG, MSH2, PMS2 and RAD50 genes. …”

Data_Sheet_1_Ataxia with oculomotor apraxia type 2 caused by a novel homozygous mutation in SETX gene, and literature review.docx by Shuaishuai Chen (7275431)

“…She had elevated AFP, increased serum follicle-stimulating hormone (FSH) and luteinizing hormone (LH) and decreased anti-Müllerian hormone (AMH) levels. We identified a novel homozygous missense mutation of the SETX gene, c.7118 C>T (p. …”

Data_Sheet_1_Effectiveness and Safety of a Prolonged Hemodynamic Support by the IVAC2L System in Healthy and Cardiogenic Shock Pigs.docx by Clément Delmas (4021211)

“…Non-sustained ventricular arrhythmias were frequent at implantation (50%). A non-significant hemolysis was observed under support in CS pigs. …”

File S1 - Impact of Glucocorticoid Receptor Density on Ligand-Independent Dimerization, Cooperative Ligand-Binding and Basal Priming of Transactivation: A Cell Culture Model by Steven Robertson (414616)

“…GR levels and the ability to dimerize influences potency (log EC₅₀) of transactivation in a range of ligands. …”

Quantification and bioinformatic analysis of the proteins enriched in ExPEC EVs. by Min Jiang (56794)

Cold-Adapted Viral Attenuation (CAVA): Highly Temperature Sensitive Polioviruses as Novel Vaccine Strains for a Next Generation Inactivated Poliovirus Vaccine by Barbara P. Sanders (2584447)

“…Furthermore, decreases in infectious titers, viral RNA, and protein levels were measured during infection at 37°C, suggesting a block in the viral replication cycle at RNA replication, protein translation, or earlier. …”

Image_1_Alzheimer’s disease biomarkers in patients with obstructive sleep apnea hypopnea syndrome and effects of surgery: A prospective cohort study.JPEG by Weili Kong (3739831)

“…The sixth month of postoperation, the plasma AD biomarkers (Aβ42, Aβ40, t-tau, p-tau) in plasma levels decreased significantly (0.23 ± 0.17 vs. 0.20 ± 0.16, p = 0.0001; 29.24 ± 32.52 vs. 23.52 ± 24.46, p = 0.0046; 11.88 ± 7.05 vs. 8.88 ± 6.21, p = 0.0001;26.31 ± 14.41 vs. 20.43 ± 10.50, p = 0.0001). …”

Data_Sheet_1_Comparison of dural puncture and dural incision in deep brain stimulation surgery: A simple but worthwhile technique modification.docx by Shiying Fan (5457797)

“…Background<p>The accuracy of the deep brain stimulation (DBS) electrode placement is influenced by a myriad of factors, among which pneumocephalus and loss of cerebrospinal fluid that occurs with dural opening during the surgery are considered most important. …”

Data_Sheet_1_Impact of Coinfection With SARS-CoV-2 and Influenza on Disease Severity: A Systematic Review and Meta-Analysis.docx by Zhou Guan (3723796)

“…However, mortality was found significantly decreased in the studies from China (OR = 0.51, 95%CI: 0.39, 0.68; I² = 26.50%), while significantly increased outside China (OR = 1.56, 95%CI: 1.12, 2.19; I² = 1.00%). …”

High flow nasal oxygen (HFNO) in the treatment of COVID-19 infection of adult patients from – An emergency perspective: A systematic review and meta-analysis by Nabil, Shallik

“…HFNO was associated with a significant decrease in mortality and intubation rates (0.28 (95% CI; 0.19, 0.39) and 0.28 (95% CI; 0.18, 0.41), respectively). …”
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The Physiological Effects of Deleting the Mouse <em>Slc30a8</em> Gene Encoding Zinc Transporter-8 Are Influenced by Gender and Genetic Background by Lynley D. Pound (150058)

“…</p> <h3>Results</h3><p>Male C57BL/6J <em>Slc30a8</em> knockout (KO) mice had normal fasting insulin levels and no change in glucose-stimulated insulin secretion (GSIS) from isolated islets in marked contrast to the ∼50% and ∼35% decrease, respectively, in both parameters observed in male mixed genetic background <em>Slc30a8</em> KO mice. …”

Data Sheet 1_Trends in prescription opioid use in Europe: A DARWIN EU® multinational cohort study including seven European countries.docx by Junqing Xie (7514219)

“…</p>Conclusion<p>Despite a decrease in new opioid prescriptions in many European countries, the prevalence of opioid use remained largely stable over the last decade. …”

High flow nasal oxygen (HFNO) in the treatment of COVID-19 infection of adult patients from – An emergency perspective: A systematic review and meta-analysis by Nabil, Shallik

“…HFNO was associated with a significant decrease in mortality and intubation rates (0.28 (95% CI; 0.19, 0.39) and 0.28 (95% CI; 0.18, 0.41), respectively). …”
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Table_2_The mutual interactions among Helicobacter pylori, chronic gastritis, and the gut microbiota: a population-based study in Jinjiang, Fujian.XLSX by Hanjing Li (16874217)

“…Objectives<p>Helicobacter pylori (H. pylori) is a type of bacteria that infects the stomach lining, and it is a major cause of chronic gastritis (CG). …”