Disrupting Glycolysis-promoting Genes Extends <i>C</i>. <i>elegans</i> Healthspan, Whereas High Glucose and Gluconeogenic Gene Disruptions Shorten Healthspan. by Brian Onken (86790)

“…Trials with 5 and 13 day old animals also showed impaired older age locomotion in 4% glucose (Supplemental <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1008982#pgen.1008982.s002" target="_blank">S1A and S1B Fig</a>). …”

(a) Data Acquisition System (b) Real time data collection. by Shaheer Ahmed Khan (17797647)

Exploring the Impacts of Conformer Selection Methods on Ion Mobility Collision Cross Section Predictions by Felicity F. Nielson (10170218)

“…Based on our analyses, we found Boltzmann weighting to be a good trade-off between precision and theoretical accuracy. …”

Supplementary Figures 1-8 from Targeting Notch Signaling with a Notch2/Notch3 Antagonist (Tarextumab) Inhibits Tumor Growth and Decreases Tumor-Initiating Cell Frequency by Wan-Ching Yen (11520727)

Hypoxia stress exerts responses involving the HPA and HPT axes. by Jingqun Ao (381882)

Sensitivity analyses: impact on the results of varying the proportion of patients with CD4+ count ≤50 cells/µl. by Romain Micol (237817)

“…</p><p>***The proportion of patients attending the HIV clinic for the first time with CD4+ count ≤50 cells/µl is 81.2% as baseline. Thus the reduction of this latter proportion by 25% decreased this proportion to 60.75%.…”

The ORF7a protein of SARS-CoV-2 initiates autophagy and limits autophagosome-lysosome fusion via degradation of SNAP29 to promote virus replication by Peili Hou (4737219)

“…In this study, we demonstrate that overexpression of the SARS-CoV-2 ORF7a protein activates LC3-II and leads to the accumulation of autophagosomes in multiple cell lines, while knockdown of the viral <i>ORF7a</i> gene via shRNAs targeting <i>ORF7a</i> sgRNA during SARS-CoV-2 infection decreased autophagy levels. …”

CK8 knockdown and ROCK1 inhibitor suppressed rTsSPc-induced disruption of the Caco-2 monolayer and blocked rTsSPc-promoted IIL invasion. by Wen Wen Zheng (17721404)

Transgenerational alteration and inheritance of DNA methylation patterns in 20 randomly chosen S1 plants derived from a Hg²⁺(50 µm)-stressed S0 individual. by Xiufang Ou (136093)

Food Polyphenols Fail to Cause a Biologically Relevant Reduction of COX-2 Activity by Ina Willenberg (803704)

“…<div><p>Epidemiologic studies show a correlation between the dietary intake of food polyphenols and beneficial health effects. …”

Curcumin restores D-gal-induced SCs TJ damage <i>in vitro.</i> by Chen Xue (699418)

D-gal-induced aging led to tight junction damage in SCs <i>in vitro.</i> by Chen Xue (699418)

Protein Tyrosine Phosphatase Oligomerization Studied by a Combination of ¹⁵N NMR Relaxation and ¹²⁹Xe NMR. Effect of Buffer Containing Arginine and Glutamic A... by Jascha Blobel (2383873)

“…They have been applied to study the oligomerization equilibrium of a low-molecular-weight protein tyrosine phosphatase in the presence of 50 mM arginine and 50 mM glutamic acid. …”

Protein Tyrosine Phosphatase Oligomerization Studied by a Combination of ¹⁵N NMR Relaxation and ¹²⁹Xe NMR. Effect of Buffer Containing Arginine and Glutamic A... by Jascha Blobel (2383873)

“…They have been applied to study the oligomerization equilibrium of a low-molecular-weight protein tyrosine phosphatase in the presence of 50 mM arginine and 50 mM glutamic acid. …”

Curcumin restores aging-induced disruption of the BTB in mice by activating autophagy in mouse testes injected with D-gal. by Chen Xue (699418)

Activation of the AMPK/mTOR signaling pathway correlates with curcumin-activated autophagy to restore D-gal-induced tight junction damage in SCs. by Chen Xue (699418)

DataSheet_2_A cyclic peptide-based PROTAC induces intracellular degradation of palmitoyltransferase and potently decreases PD-L1 expression in human cervical cancer cells.docx by Yu-Ying Shi (15975992)

“…Introduction<p>Our previous research has found that degradation of palmitoyltransferase in tumor cells using a linear peptide PROTAC leads to a significant decrease in PD-L1 expression in tumors. …”

DataSheet_1_A cyclic peptide-based PROTAC induces intracellular degradation of palmitoyltransferase and potently decreases PD-L1 expression in human cervical cancer cells.docx by Yu-Ying Shi (15975992)

“…Introduction<p>Our previous research has found that degradation of palmitoyltransferase in tumor cells using a linear peptide PROTAC leads to a significant decrease in PD-L1 expression in tumors. …”

The levels of TBARS product in thalassemia red blood cells treated with 6-shogaol-rich ginger extract at concentrations of 50, 100, and 200 µg/mL and ascorbic acid (AA) at concentr... by Hataichanok Chuljerm (19144293)

C5a concentration throughout the study period. by Dzenita Smailhodzic (659524)