Determining the role of missense mutations in the POU domain of HNF1A that reduce the DNA-binding affinity: A computational approach by Sneha P. (3926957)

“…<div><p>Maturity-onset diabetes of the young type 3 (MODY3) is a non-ketotic form of diabetes associated with poor insulin secretion. …”

Inhibition of Nuclear Factor-Kappa B Activation Decreases Survival of <i>Mycobacterium tuberculosis</i> in Human Macrophages by Xiyuan Bai (407197)

“…Targeted pharmacologic inhibition of NFκB activation using BAY 11-7082 (BAY, an inhibitor of IκBα kinase) or an adenovirus construct with a dominant-negative IκBα significantly decreased the number of viable intracellular mycobacteria recovered from THP-1 macrophages four and eight days after infection. …”

Normalized expression values for the 50 most significant differentially expressed genes in canine peripheral nerve sheath tumors. by Lydia Lam (13783306)

Longer polyQ sequences increase the tendency of AR to localize to nuclear puncta in the presence of DHT. by Carlos M. Roggero (11909585)

Methyl Jasmonate Improves Cadmium Tolerance by Reducing Cadmium Accumulation, Enhancing Cell Wall Immobilization and Modulating Transcriptional Regulation in <i>Malus</i> Rootstock by Siyu Liu (825600)

“…The physicochemical and molecular responses of Malus hupehensis exposed to 0 or 50 μM Cd with or without exogenous 5 μM MeJA or 50 μM ibuprofen (IBU) for 3 d were explored via a hydroponic experiment. …”

Time evolution of patient outcomes for a range of neutrophil (<i>N</i>) and cortisol (<i>C</i>) initial conditions for model (1). by Manuel Mai (497861)

Substitution of a lysine residue at position 8 of two model 9mer H2-K^b epitope precursors leads to a marked decrease of N-terminus trimming by ERAP1 <i>in vitro</i>. by Irini Evnouchidou (375919)

“…<p><i>Panels </i><i>A</i><i> and </i><i>B</i>, peptides LSIINFEKL and the variant LSIINFEAL (both at 50 µM) were incubated with 7.8 nM of ERAP1 for 1 hr at 37°C and the products analyzed by RP-HPLC. …”

FOXO1 Suppresses SMAD-Induced <i>Fshb</i> Gene Expression. by Chung Hyun Park (665717)

Gender role and gender identity measures in 50 individuals with autism spectrum disorder (ASD) and 53 neurotypical controls. by Susanne Bejerot (518053)

Analysis of bile salt sensitivity and LPS profiles in the wild-type and <i>bipA</i>-deleted strains of <i>E. coli</i> and <i>S</i>. Typhimurium. by Eunsil Choi (8271039)

Cortical distribution of neurons born at E11.5, E13.5, E15.5, or E17.5 in P0 mice. by Qingfa Chen (739620)

“…The number of CUX1+ cells co-labeled with BrdU at E13.5 was greater in both mutants (E, F), while the number at E15.5 was lower in <i>Nestin;Epha4</i>^<i>fx/fx</i> mice (E) and greater in <i>GFAP;Epha4</i>^<i>fx/fx</i> mice compared to controls (F). …”

Penetration stress and resistances as a function of base radius. by Siul Ruiz (757454)

“…Penetration stress (a) decreases for increasing base radius for fixed soil mechanical properties. …”

T-cell priming in DC/T-cell co-culture. WT and Lcn2^−/− DCs were pre-treated for 6 h with LPS and then co-cultured with T-cells. by Melanie Floderer (596361)

“…T-cells (OT-I) were co-cultured with 6 h-LPS-treated Lcn2^−/− DCs (black bars) or 6 h-LPS-treated WT DCs (grey bars). Five independent experiments were performed in triplicate. …”

Exercise testing criteria to diagnose lower extremity peripheral artery disease assessed by computed-tomography angiography by O. Stivalet (6890189)

“…The receiver-operating-characteristic curve was used to define a cut-off point corresponding to the best area under the curve (AUC; [CI95%]) to detect arterial stenosis ≥50% as determined by the CTA.…”

Oral Efficacy of Apigenin against Cutaneous Leishmaniasis: Involvement of Reactive Oxygen Species and Autophagy as a Mechanism of Action by Fernanda Fonseca-Silva (356488)

“…</p><p>Methodology/Principal Finding</p><p>Apigenin reduced the infection index in a dose-dependent manner, with IC₅₀ values of 4.3 μM and a selectivity index of 18.2. …”

Greater T cell apoptosis resulting in reduced tumor cell apoptosis after co-culture with PBMCs carrying the IL-10 non-ATA haplotype versus the IL-10 ATA haplotype. by Yaw-Cheng Wang (147089)

Classically activated macrophage signature in wild-type and miR-155 knockout macrophages. by Kyle A. Jablonski (839741)

Exercise testing criteria to diagnose lower extremity peripheral artery disease assessed by computed-tomography angiography - Fig 2 by O. Stivalet (6890189)

“…<p><b>ROC curves of the different tests to diagnose arterial stenosis ≥ 50% in the overall population (<i>n = 126 limbs</i>)</b> (A) and in the population with an ABI > 0.91 (<i>n = 60 limbs</i>) (B). …”

Design and Synthesis of Novel sEH Inhibitors for the Treatment of Inflammatory Bowel Disease by Huashen Xu (13987046)

“…Especially, lead compounds <b>A1</b> and <b>A9</b> showed potent inhibitory activities against sEH (<b>A1</b> and <b>A9</b>; hsEH IC₅₀ = 0.1 nM, msEH IC₅₀ = 0.1 nM). …”

Design and Synthesis of Novel sEH Inhibitors for the Treatment of Inflammatory Bowel Disease by Huashen Xu (13987046)

“…Especially, lead compounds <b>A1</b> and <b>A9</b> showed potent inhibitory activities against sEH (<b>A1</b> and <b>A9</b>; hsEH IC₅₀ = 0.1 nM, msEH IC₅₀ = 0.1 nM). …”