Image_1_Nose-Only Water-Pipe Smoke Exposure in Mice Elicits Renal Histopathological Alterations, Inflammation, Oxidative Stress, DNA Damage, and Apoptosis.TIF by Abderrahim Nemmar (285370)

“…The duration of the session was 30 min/day and 5 days/week. Control mice were exposed to air. …”

Data_Sheet_1_Expression and Functional Analysis of lncRNAs Involved in Platelet-Derived Growth Factor-BB-Induced Proliferation of Human Aortic Smooth Muscle Cells.PDF by Jia-Jie Lin (11398619)

“…HIF1A-AS2 suppression decreased HASMC proliferation via the miR-30e-5p/CCND2 mRNA axis. …”

DataSheet_1_Natural variation of RGN1a regulates grain number per panicle in japonica rice.pdf by Quan Zhang (168081)

“…The RGN1a mutation caused 37.2%, 27.8%, 51.2%, and 25.5% decreases in grain number, primary branch number per panicle, secondary branch number per panicle, and panicle length, respectively. …”

DataSheet4_Primary ovarian insufficiency consequence of autoimmune diseases: a bidirectional two-sample Mendelian randomization study.pdf by Yongming Du (807059)

“…</p>Results<p>The MR analyses revealed that genetically determined coeliac disease (CeD) (OR = 1.124, 95% CI 1.033-1.224, P = 0.007), vitiligo (OR = 1.092, 95% CI 1.003-1.188; P = 0.042), systemic lupus erythematosus (SLE) (OR = 1.122, 95% CI 1.030-1.223, P = 0.008), and selective immunoglobulin A deficiency (SIgAD) (OR = 0.866, 95% CI: 0.776-0.967, P = 0.011) exhibited significant causal relationships with POI. We also found suggestive evidence of positive effect of Addison’s disease (AD) towards POI (OR_5e-6 = 1.076, 95% CI 1.002-1.154, P = 0.043).…”

Table_1_Expression and Functional Analysis of lncRNAs Involved in Platelet-Derived Growth Factor-BB-Induced Proliferation of Human Aortic Smooth Muscle Cells.XLS by Jia-Jie Lin (11398619)

“…HIF1A-AS2 suppression decreased HASMC proliferation via the miR-30e-5p/CCND2 mRNA axis. …”

Image_1_PLAU Promotes Cell Proliferation and Epithelial-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma.TIF by Guangjin Chen (1989892)

“…Besides, genes associated with PLAU were also enriched in EMT pathways. We further validated the bioinformatics analysis results by in vivo and in vitro experiments. …”

Table_2_PLAU Promotes Cell Proliferation and Epithelial-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma.DOCX by Guangjin Chen (1989892)

“…Besides, genes associated with PLAU were also enriched in EMT pathways. We further validated the bioinformatics analysis results by in vivo and in vitro experiments. …”

Image_1_Induction of Autophagy by Ursolic Acid Promotes the Elimination of Trypanosoma cruzi Amastigotes From Macrophages and Cardiac Cells.tif by María Cristina Vanrell (3924611)

“…To test this effect, the cells were infected with T. cruzi for 24 h and then treated with UA (5–10 µM). The data showed that UA significantly decreased the number of amastigotes found in infected cells in comparison with non-treated cells. …”

Table 6_Metabolic readouts of tumor instructed normal tissues (TINT) identify aggressive prostate cancer subgroups for tailored therapy.docx by Ilona Dudka (8857529)

“…The levels of six metabolites differentiated between the two groups; myo-inositol, lysine, serine and combined signal of lysine/leucine/arginine were increased in benign samples near high-grade tumors (B ISUP 3 + 4) compared to near low-grade tumors (B ISUP 1 + 2), while levels of ethanolamine and lactate were decreased. Additionally, we revealed metabolic differences in non-cancer tissues as a function of their distance to the nearest tumor. …”

Flowchart of study patients. by Xuan Zhou (329338)

“…Subgroup analysis showed a negative association between the albumin infusion and sepsis risk in the AP patients with serum albumin ≤ 3.5g/L (adjusted OR=0.29, 95%CI = 0.08–0.77).</p><p>Conclusion</p><p>In this study, we found an association between albumin administration and a lower risk of sepsis in AP patients, which persisted after multivariate adjustment. …”

DataSheet1_Amplifying Flood Risk Across the Lower Yellow River Basin, China, Under Shared Socioeconomic Pathways.docx by Jinbo Song (4688455)

“…Under SSP126, SSP245, and SSP585 scenarios, the areas with increasing flood hazards during 2015–2045 accounted for 65.2, 69.0, and 64.5% of the entire YRB. In the spatial pattern, flood hazards decreased from southeastern to northwestern parts of the YRB. …”

DataSheet_1_Circulating Brain-Derived Neurotrophic Factor, Antioxidant Enzymes Activities, and Mitochondrial DNA in Bipolar Disorder: An Exploratory Report.docx by Dong Wang (73290)

“…Unexpectedly, we observed no significant correlation between mtDNA content and BDNF in BD patients (p > 0.05).…”

Image_2_BTG2 suppresses renal cell carcinoma progression through N6-methyladenosine.tiff by Fuming Qi (14256764)

“…Moreover, we found that m⁶A methylation modifies the 5’UTR of BTG2 to promote its mRNA stability by binding to IGF2BP2. …”

Table1_Comprehensive Analysis of the Transcriptome-Wide m6A Methylation Modification Difference in Liver Fibrosis Mice by High-Throughput m6A Sequencing.DOCX by Chang Fan (5305073)

“…In an additional cell experiment, we also observed that the decreased expression of WTAP induced the development of LF as a result of promoting hepatic stellate cell (HSC) activation. …”

Image_2_Integrative metagenomic and lipidomic analyses reveal alterations in children with obesity and after lifestyle intervention.jpeg by Chunyan Yin (5384525)

“…</p>Conclusion<p>We linked altered gut microbiota and serum lipid levels in children with obesity to clinical indicators, indicating a potential impact on glucose metabolism via lipids. …”

Image_1_BTG2 suppresses renal cell carcinoma progression through N6-methyladenosine.tiff by Fuming Qi (14256764)

“…Moreover, we found that m⁶A methylation modifies the 5’UTR of BTG2 to promote its mRNA stability by binding to IGF2BP2. …”

DataSheet7_Primary ovarian insufficiency consequence of autoimmune diseases: a bidirectional two-sample Mendelian randomization study.pdf by Yongming Du (807059)

“…</p>Results<p>The MR analyses revealed that genetically determined coeliac disease (CeD) (OR = 1.124, 95% CI 1.033-1.224, P = 0.007), vitiligo (OR = 1.092, 95% CI 1.003-1.188; P = 0.042), systemic lupus erythematosus (SLE) (OR = 1.122, 95% CI 1.030-1.223, P = 0.008), and selective immunoglobulin A deficiency (SIgAD) (OR = 0.866, 95% CI: 0.776-0.967, P = 0.011) exhibited significant causal relationships with POI. We also found suggestive evidence of positive effect of Addison’s disease (AD) towards POI (OR_5e-6 = 1.076, 95% CI 1.002-1.154, P = 0.043).…”

Image_4_PLAU Promotes Cell Proliferation and Epithelial-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma.TIF by Guangjin Chen (1989892)

“…Besides, genes associated with PLAU were also enriched in EMT pathways. We further validated the bioinformatics analysis results by in vivo and in vitro experiments. …”

DataSheet_1_Genome-wide analysis of radish AHL gene family and functional verification of RsAHL14 in tomato.docx by Weifang Chen (1832731)

“…Additionally, RsAHL14 induced a dwarf phenotype in tomato plants, and RsAHL14-overexpression tomato plants presented significantly decreased expression levels of the gibberellin (GA) synthetic genes ent-Copalyl diphosphatase, GA3ox-3/-4/-5, and GA20ox-1/-2/-3, but significantly increased expression of the degradation gene GA2ox-1/-3. …”

The interaction between RE1-silencing transcription factor (REST) and heat shock protein 90 as new therapeutic target against Huntington’s disease by Raúl Orozco-Díaz (7067624)

“…To assess the effects of Hsp90 we used antisense oligonucleotide, and evaluated the levels mHtt and REST levels. …”