First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…Low-dose <b>35m</b> remarkably decreases LPS-induced IL-1β release both <i>in vitro</i> and <i>in vivo</i> by blocking the activation of NLRP3, indicating that <b>35m</b> can be a potential orally active therapeutic agent for the treatment of NLRP3-related diseases.…”

Antagonism of ghrelin receptors resulted in decreased reward and delayed reductions of EtOH-motivated behaviors with an overall increased sensitivity in RYGB rats. by Andras Hajnal (299955)

The human neutrophil IL-1β secretory response, in contrast to the CXCL8/IL-8 secretory response decreases as MOI increases. by Florencia Sabbione (4862455)

Overexpression of let-7b decreases NF-κB activity and downregulates COX-2, CyclinD1 protein expression. by Gui-gen Teng (380044)

“…(C–D) Overexpression of let-7b by mimics downregulated MyD88, p65/RelA, P50/NF-κB1 and IL-8 mRNA levels, and decreased NF-κB luciferase activity compared to let-7b negative control. …”

Decreased vessel number and increased vessel caliber in <i>Fzd4</i>^+/- mice after ocular ischemic retinopathy. by Michael H. Ngo (3143202)

Multinomial logistic model of the effects of a cluster of phenolic compounds on host and parasitoid survival across development among larvae that survived to at least 50 mg. by Noah H. Rose (703745)

Injection of rIL-6 in IL-6KO mice decreased chronic disease severity following CB3/LPS treatment. by Maya C. Poffenberger (262165)

“…(B) Chronic cardiac disease histology was scored blindly by a four tier grading system to determine severity differences: grade 1, 0–10% pathology; grade 2, 11–25%; grade 3, 26–50%; grade 4, greater than 50% (black circles indicate wt mice with DMEM, white circles indicate IL-6KO mice with DMEM, grey circles indicate IL-6KO mice with rIL-6) (bar is mean±SE, *p<0.05). …”

Leptin Decreases MAFbx and MuRF1 Protein Expression in Gastrocnemius Muscle of Wild Type and <i>ob/ob</i> Mice. by Neira Sáinz (260167)

Decreased levels of NMDAR2B in the synaptic plasma membrane of spinal cord of CCI-mice treated with compound 30 at 56 dpi. by Xavier Xifró (719821)

[Na⁺]_i is decreased in SLO3 mutant sperm and in sperm treated with the SLO3 inhibitor clofilium. by Julio C. Chávez (399841)

Adiponectin reduces neutrophil phagocytosis by decreasing the phosphorylation of PKB and ERK 1/2 but not p38 in response to <i>E. coli</i>. by Alessandra Rossi (8710)

Leishmanization with <i>L</i>. <i>major</i> + Pam3CSK4 decreases lesion size and parasite burden in mice. by Lu Huang (211625)

Mean (±95%CI) Rating of perceived exertion measured using a numeric scale (1–10) for the Nordic hamstring exercise, Sprint and control groups. by Nicholas J. Ripley (14709756)

Helminth co-infection results in decreased number of CD11b⁺ cells and antimicrobial peptide expression in colonic tissue. by Libo Su (596288)

Knockdown of Rab27a and disruption of microtubules decreased the number of granules docked at the PM. by Dongfang Liu (241581)

Mucosal vaccination with M2e5x VLP decreases innate immune cell recruitments after influenza virus infection. by Young-Tae Lee (467116)

Comparison of the decrease of CFU in CSF and blood between treatment groups within the first 6 h after treatment. by Luca G. Valente (12463057)

Multiple trauma and hemorrhagic shock induce a transcriptional immune response. by Marc-Alexander Oestreich (13961375)

Proliferative keratinocytes and BrdU-positive label retaining cells are decreased in <i>Med1^epi−/−</i> mice. by Fumihito Noguchi (615295)

“…Scale bars = 50 µm. B: Quantification of proliferating cells on days 1, 3 and 5 after injury. …”

Relationship between OLT and soil temperature at 50-cm (a), the depth at which charcoal was measured (b), and the active layer depth (c) measured in the field for a subset of the d... by Kristofer D Johnson (557206)

“…</p> <p><strong>Abstract</strong></p> <p>Permafrost is tightly coupled to the organic soil layer, an interaction that mediates permafrost degradation in response to regional warming. We analyzed changes in permafrost occurrence and organic layer thickness (OLT) using more than 3000 soil pedons across a mean annual temperature (MAT) gradient. …”