Combination of DNA Damage, Autophagy, and ERK Inhibition: Novel Evodiamine-Inspired Multi-Action Pt(IV) Prodrugs with High-Efficiency and Low-Toxicity Antitumor Activity by Xiao-Meng Liu (778197)

“…Among them, compound <b>10</b> exhibited a 118-fold enhancement in the IC₅₀ value compared to cisplatin and low toxicity to normal cells. …”

Combination of DNA Damage, Autophagy, and ERK Inhibition: Novel Evodiamine-Inspired Multi-Action Pt(IV) Prodrugs with High-Efficiency and Low-Toxicity Antitumor Activity by Xiao-Meng Liu (778197)

“…Among them, compound <b>10</b> exhibited a 118-fold enhancement in the IC₅₀ value compared to cisplatin and low toxicity to normal cells. …”

Combination of DNA Damage, Autophagy, and ERK Inhibition: Novel Evodiamine-Inspired Multi-Action Pt(IV) Prodrugs with High-Efficiency and Low-Toxicity Antitumor Activity by Xiao-Meng Liu (778197)

“…Among them, compound <b>10</b> exhibited a 118-fold enhancement in the IC₅₀ value compared to cisplatin and low toxicity to normal cells. …”

Combination of DNA Damage, Autophagy, and ERK Inhibition: Novel Evodiamine-Inspired Multi-Action Pt(IV) Prodrugs with High-Efficiency and Low-Toxicity Antitumor Activity by Xiao-Meng Liu (778197)

“…Among them, compound <b>10</b> exhibited a 118-fold enhancement in the IC₅₀ value compared to cisplatin and low toxicity to normal cells. …”

Oligomeric Aβ₄₂-induced apoptotic cell death was decreased by increased IL-10 secreted from hASC and/or murine BV2 cells. by Saeromi Kim (132677)

Effect of the Hill coefficient on estimates of <i>ε</i>_max (left column) and IC₅₀ (right column) for the logistic model with drug applied to the growth rate <... by Hope Murphy (8843516)

Partial correlation of <i>ε</i>_max (left column) and IC₅₀ (right column) estimates at 10 days and 20 days (first and second bar of each color, respectively) o... by Hope Murphy (8843516)

3D snapshots of the tumor system with single-agent BHQ880 treatment at (a) time step 40, (b) time step 50 and (c) time step 120. by Minna Qiao (836556)

A decreased neurovirulence is observed for rOC/S_G758R variant in 21 day-old BALB/c female mice infected by the intracerebral route. by Alain Le Coupanec (421447)

E₅₀ values. by Junxia Zhou (14381598)

Age-stage specific survival rate (<i>s</i>_<i>xj</i>) of <i>A</i>. <i>glycines</i>. by Aonan Zhang (8933630)

Age-stage-specific survival rate (<i>s</i>_<i>xj</i>) of <i>A</i>. <i>glycines</i>. by Aonan Zhang (8933630)

Conditional depletion of RPS0A significantly decreases translation initiation rates. by Tomáš Kouba (153719)

GXM decreases the trans-endothelial electrical resistance (TEER) and transmigration of <i>C</i>. <i>neoformans</i> through HBECs in a blood brain barrier (BBB) model. by Hiu Ham Lee (15374677)

Predicted metabolite levels for each reaction intermediate shown in Figure 7 under conditions in which the NAD+:NADH ratio is 31 (Bennett et al. [26]), or decreased by either 0.1-f... by William R. Cannon (608586)

Assessment of cell proliferation within the vocal fold muscle following DFATs transplantation. by Ikuo Mikoshiba (9312007)

Test characteristics for identifying stenosis ≥ 50% in any limb from aorta till popliteal artery in the overall population (<i>n = 126 limbs</i>). by O. Stivalet (6890189)

The receiver operating characteristic curve (ROC) for using ucfDNA molecules with a size range of 130 to 160 bp within the DHSs to distinguish control subjects with hematuria from... by Meihui Chen (1670020)

Mutations in <i>DHFR-TS</i> and their role in methotrexate resistance. by Sophia Bigot (16469992)

PTR1 DNA editing and absence of phenotype. by Sophia Bigot (16469992)