Microsatellite Interruptions Stabilize Primate Genomes and Exist as Population-Specific Single Nucleotide Polymorphisms within Individual Human Genomes by Guruprasad Ananda (599807)

“…Modeling the adenomatous polyposis coli tumor suppressor gene sequence, we observed that a single base substitution interruption reduced strand slippage error rates five- to 50-fold, relative to a perfect repeat, during synthesis by DNA polymerases α, β, or η. …”

Hormone addition results in chromatin changes at individual GR-regulated genes. by Chuong D. Pham (111374)

“…Bars indicate standard error of the mean from 6 PCR reactions. In addition to the progressive decrease at Nuc D at 20 mins, 1 hr and especially 4 hrs, moderately decreased signal at Nucs D and F was also seen at 4 hrs (consistent, perhaps, with the somewhat lower occupancy, especially for Nuc D, seen in Fig. 2A). …”

Data from flow assays with neutrophils treated with RPMI or bromelain. by Jessica M. Banks (482857)

“…(b) Data from primary human neutrophil flow assays with P-selectin substrates reveal that the number of interacting cells is decreased when neutrophils are treated with 50 µg/mL bromelain in RPMI on regions of “high” and “low” immobilized P-selectin. (** <i>p</i><0.05) Treatment with saturating levels of anti-PSGL-1 clone KPL-1 significantly decreased P-selectin mediated tethering on high P-selectin substrates (** <i>p</i><0.05). …”

Microhematuria levels and sex specific protein alterations in urine over time in Hgf-Cdk4^R24C OH-BBN induced mice depict events of carcinogenesis, early immune response... by Iliana K. Kerzeli (11090169)

“…Repeated measurements were analyzed by a generalized least square (GLS) to model the effect of gender on the disease at a specific time point. …”

Increased angiogenesis in scar area after myocardial injection of myoblasts. by Yasuhiro Nakamura (312045)

“…(C) FACS analysis showed an increase in the number of CD45⁺ blood cells (arrows) and CD45^- CD31⁻ Sca-1⁺ cardiac progenitor cells (black boxes) and a decrease in the number of CD45⁻ CD31⁺ endothelial cells (red boxes) in the hearts of mice receiving wild-type myoblasts, <i>MyoD^−/−</i> myoblasts, or medium alone. …”

Analyzing the clinical benefit of newer therapies for advanced or metastatic non-small-cell lung cancer: application of the ESMO-magnitude of clinical benefit scale v1.1 by Ricardo García-Fumero (11042247)

“…</p> <p>ESMO-MCBS scores were calculated for 42 positive clinical trials. 54.8% met the ESMO-MCBS thresholds for clinically meaningful benefit (final grade of 4 or 5). That percentage decreased to 40.5% when considering the point estimate of the HR. 50.0% of the trials had no published scorecard on the ESMO website and discrepancies affected 11 (26.2%) studies.…”

Fih-1 negatively regulates Vegf-aa₁₆₅ in zebrafish embryos. by Ju-Hoon So (649651)

“…(<b>C</b>) Ectopic expression of Fih-1 decreases the level of <i>vegf-aa₁₆₅</i> expression in a dose-dependent manner at 28 hpf. …”

Effects of TNFα on markers of mitochondrial mass and expression of several effector proteins for mitochondrial biogenesis. by Theodore J. Kalogeris (575591)

“…Experiments were repeated 3–4 times per time point. * denotes significant decrease in apparent mass compared with respective time point control (P<0.0001). …”

Table_1_Climate change may increase Quebec boreal forest productivity in high latitudes by shifting its current composition.docx by Abderrahmane Ameray (8731632)

“…This study provides a good starting point to support future research on the multiple factors affecting forest C budget under global change.…”

Stereoselective Alkali-Metal Catalysts for Highly Isotactic Poly(<i>rac</i>-lactide) Synthesis by Yangyang Sun (1446925)

“…The isoselective mechanism is chain-end control through the analysis of the stereoerrors in the microstructure of a final polymer; thus, isotactic multiblock structure polymers are obtained, and the highest melt point can reach 192.5 °C. …”

Dynamics of Transcription Factor Binding Site Evolution by Murat Tuğrul (823506)

“…We use a biophysical model for directional selection on gene expression to estimate the rates of gain and loss of transcription factor binding sites (TFBS) in finite populations under both point and insertion/deletion mutations. …”

Proton Transfer and Structure-Specific Fluorescence in Hydrogen Bond-Rich Protein Structures by Dorothea Pinotsi (1305144)

“…The importance of proton transfer on the intrinsic fluorescence observed in protein fibrils is signified by large reductions in the fluorescence intensity upon either fully protonating, or deprotonating, the fibrils at pH = 0 or 14, respectively. Thus, our results point to the existence of a structure-specific fluorophore that does not require the presence of aromatic residues or multiple bond conjugation that characterize conventional fluorescent systems. …”

Supplemental files from Endogenous glucose production in patients with glycogen storage disease type Ia estimated by oral D [6,6-2H2]-glucose by Alessandro Rossi (11069448)

“…</strong> Less than 25% decrease in  concentration between the peak and the last time point were observed in subject 008 (glucose-SIB  test 1), subject 019 (glucose-SIB test 2) and subject 020 (glucose-SIB test 2) disqualifying these data  for computational analysis.…”

CT enhancement in healthy mice after injection of AuNP contrast agents. by Jeffrey R. Ashton (521391)

“…All nanoparticles showed an exponential decrease in concentration. C225 had a significantly shorter half-life than VHH-122 or PEG. …”

Increased S129-P-α-synuclein in acutely treated curcumin mice. by Kateri J. Spinelli (293686)

“…(D) Analysis of GFP/S129-P colocalization (CoLoc channel), and quantification of the Pearson’s Colocalization Coefficient (E), shows a decrease in S129-P at GFP-positive terminals. …”

Stereoselective Alkali-Metal Catalysts for Highly Isotactic Poly(<i>rac</i>-lactide) Synthesis by Yangyang Sun (1446925)

“…The isoselective mechanism is chain-end control through the analysis of the stereoerrors in the microstructure of a final polymer; thus, isotactic multiblock structure polymers are obtained, and the highest melt point can reach 192.5 °C. …”

Trends in overall mortality and from diseases of the circulatory system in elderly individuals in Rio Branco, Acre, 1980-2012 by Polyana Caroline de Lima Bezerra (5383013)

“…There was a tendency for death rates due to diseases of the circulatory system to decline among elderly men and grow among elderly women. …”

Ca²⁺ sparklets in DSM are affected by, but not dependent upon, signals from the SR. by Peter Sidaway (190696)

“…In the presence of the VGCC antagonist R-(+)-Bay K 8644 (1 μM) and CPA (10 μM), there was a significant decrease in the frequency (D) but not amplitude (E) of Ca²⁺ sparklets. …”

POLGdn expression led to the depletion of mtDNA-encoded respiratory chain components. by Weiqin Lu (166093)

“…<p>(A) POLGdn-pcDNA4/TO construct and nucleotide sequencing analysis confirming the D1135A mutation. …”

Stereoselective Alkali-Metal Catalysts for Highly Isotactic Poly(<i>rac</i>-lactide) Synthesis by Yangyang Sun (1446925)

“…The isoselective mechanism is chain-end control through the analysis of the stereoerrors in the microstructure of a final polymer; thus, isotactic multiblock structure polymers are obtained, and the highest melt point can reach 192.5 °C. …”