Mouse transcripts most differentially dysregulated in the perifornical area of ataxin-3 transgenic animals versus control mice. by Makoto Honda (102165)

Novel Nuclear Factor-KappaB Targeting Peptide Suppresses β-Amyloid Induced Inflammatory and Apoptotic Responses in Neuronal Cells - Fig 6 by Mythily Srinivasan (3233949)

“…<p>Effect of GILZ analog (GA) treatment on human fetal brain cells (HFB): (A,B): Select GA decrease metabolic activity in Aβ_1–42 exposed HFB. …”

Video1_The mechanisms of potassium loss in acute myocardial ischemia: New insights from computational simulations.AVI by Jose M. Ferrero (6705797)

“…Our results indicate that the primary rising phase of [K+]o is mainly due to the imbalance between K⁺ efflux, that increases slightly, and K⁺ influx, that follows a reduction of the NaK pump activity by more than 50%. …”

Seizure changes during study phases. by Mark Bodner (33604)

“…It can be seen from the graphs that while both groups of subjects exhibited a significant reduction in seizures, that subjects with idiopathic seizures exhibited a greater decrease in both treatment and follow-up years than those with symptomatic seizures.…”

WIKI4 inhibits the functional outcomes of Wnt/ß-catenin signaling. by Richard G. James (114424)

“…In <b>B-F</b>, LCM = control L cell CM, WNT3A = Wnt3a CM; both 50% (vol/vol) in KSR medium.…”

DataSheet1_The mechanisms of potassium loss in acute myocardial ischemia: New insights from computational simulations.docx by Jose M. Ferrero (6705797)

“…Our results indicate that the primary rising phase of [K+]o is mainly due to the imbalance between K⁺ efflux, that increases slightly, and K⁺ influx, that follows a reduction of the NaK pump activity by more than 50%. …”

The distribution of Tbr2+ mitoses shifts to the outer subventricular zone (oSVZ) during early stages of cortical development in macaque, but not in ferret or rat. by Verónica Martínez-Cerdeño (155789)

“…There was a steady decrease in the proportion of Tbr2+ divisions occurring in the iSVZ. …”

The Antihelmintic Drug Pyrvinium Pamoate Targets Aggressive Breast Cancer by Wei Xu (28953)

“…A decrease in activity of the TIC surrogate aldehyde dehydrogenase was observed in PP-treated cells, and inhibition of WNT signaling by PP was associated with down-regulation of a panel of markers associated with epithelial-mesenchymal transition. …”

Functionally-relevant mutations in dimorphic element alleles. by William A. Rogers (451944)

“…Alignment of sequences encompassing the (B) “D” mutation, (C) “E” mutation, (D) “F” mutation, (E) and the “L” mutation. …”

The Cost-Effectiveness of Intermittent Preventive Treatment for Malaria in Infants in Sub-Saharan Africa by Lesong Conteh (231114)

DataSheet_1_Circulating Tumor DNA to Interrogate the Safety of Letrozole-Associated Controlled Ovarian Stimulation for Fertility Preservation in Breast Cancer Patients.docx by Françoise Rothé (215567)

“…No change in ctDNA level after let-COS was observed in 3 patients and the level decreased (fold-change ≤ 0.5) in two women. One patient experienced an increased (fold-change ≥ 2) in ctDNA level but without disease relapse 34 months after diagnosis.…”

Table_1_Efficacy and safety of intravitreal injection of conbercept for moderate to severe nonproliferative diabetic retinopathy.DOC by Lu Shen (161789)

“…The mean CMT decreased from 306.22 ± 77.40 to 297.97 ± 88.15 μm (p = 0.385). …”

Photo(chemo)therapy Reduces Circulating Th17 Cells and Restores Circulating Regulatory T Cells in Psoriasis by Takuya Furuhashi (276955)

“…</p> <h3>Methods</h3><p>Peripheral blood was obtained from psoriasis patients treated with bath-psoralen ultraviolet A (UVA, n = 50) or narrowband ultraviolet B (UVB, n = 18), and age-matched healthy volunteers (n = 20). …”

<i>vang-1</i> shows reproduction- and aging-related defects. by Sebastian J. Honnen (183696)

“…</b> The average brood size at 25°C in <i>vang-1(tm1422)</i> (red, <b>111±41</b> progeny; n = 28*) is significantly reduced (p<0.0001**) in comparison to WT (blue, <b>194±50</b> progeny; n = 56*). Results are shown as mean±standard deviation. …”

DataSheet_1_Optimizing linear energy transfer distribution in intensity-modulated proton therapy using the alternating direction method of multipliers.pdf by Qingkun Fan (17379391)

“…For the prostate case, the mean LET (unit: keV/µm) at the rectum decreased from 2.65 (ICR-LET) to 2.14 (ADMM-LET).…”

CPEB3-KO mice with normal mechanical sensation were more sensitive to noxious heat than WT littermate mice. by Sitt Wai Fong (2512264)

“…The total number of cells analyzed from 3 animals are shown in parentheses. Scale: 50 μm. (B) CPEB3-KO mice showed high thermal sensitivity as indicated by decreased latency to lift paws in the hot plate test (50°C). …”

Timing of commitment by mating partners. by Nicholas T. Henderson (7513340)

“…(<b>D</b>) Cumulative distribution of the duration of the indecisive phase (dashed) and committed phase (solid) in second-born cells of MAT<b>a</b> (blue, <i>n</i> = 87) and α (orange, <i>n</i> = 66). (<b>E</b>) Pheromone synthesis is high in G1 and decreases in S/G2/M. …”

Fig 1 - by M. Latorre (8840546)

“…<p>Fully developed, mechanobiologically equilibrated, axisymmetric dilatations of an initially cylindrical aortic segment caused by a mild (first column) or severe (second column) localized (via the respective parameter <i>ϑ</i>_{<i>central</i>} in Eq (<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1008273#pcbi.1008273.e024" target="_blank">9</a>)) loss of elastic fiber integrity (first row, parameter <i>c</i>^<i>e</i>, mild 32% and severe 62% reduction), decrease in collagen cross-linking (second row, parameter , mild 9%, severe 23% reduction), loss of smooth muscle contractility (third row, parameter <i>T</i>_<i>max</i>, mild 60%, severe 100% reduction), compromised mechanosensing (fourth row, parameter <i>δ</i>, mild 7.5%, severe 18.5%, absolute), or compromised mechanoregulation (fifth row, parameter <i>G</i>^<i>c</i>, mild 0.4%, severe 1.2%, relative change), with the risk factors of hypertension (third column, 50% increase in blood pressure) and aortic aging (fourth column, uniform 30% loss of elastic fiber integrity) superimposed on the mild insults. …”

<i>In-silico</i> identification of fingerprint of pyrazolyl sulfonamide responsible for inhibition of <i>N</i>-myristoyltransferase using Monte Carlo method with index of ideality... by Ashwani Kumar (55732)

“…The mechanistic interpretation of developed models explains the role of different structural attributes in predicting the pIC₅₀ of pyrazole sulfonamides extracted from the crystal structure of Leishmania major N-myristoyltransferase (NMT) along with co-crystallized myristoyl-CoA and ligands NMT106, NMT157, NMT187 and NMT236 (PDB ID: 4A2Z, 4A30, 4A32, 2WSA). …”

The Protein <i>O</i>-glucosyltransferase Rumi Modifies Eyes Shut to Promote Rhabdomere Separation in <i>Drosophila</i> by Amanda R. Haltom (664189)

“…The intracellular accumulation of Eys and the IRS defect worsen in <i>rumi</i> mutants raised at a higher temperature, and are accompanied by a ∼50% decrease in the total level of Eys. …”