The upstream signaling to Nrf1 and proteasome are to no or fewer degrees, affected in <i>SREBP1</i>-deficient cells. by Keli Liu (5937368)

“…(D) The mRNA levels of those examined genes were determined by real-time qPCR and shown as fold changes (mean ± S.D. n = 3×3) with significant decreases (*, <i>p</i><0.01) or significant increases ($, <i>p</i><0.01) relative to equivalent controls. …”

Kinetics of alpaca innate immune responses at the tracheal level in response to MERS-CoV Qatar15/2015. by Nigeer Te (7849808)

“…TFs, transcription factors; CKs, chemokines; ADs, adaptors; RT, receptor. (B) Average fold changes of ISGs, PRRs, IL8, IL1β and IRF7 genes in trachea. …”

CD40 knockdown and CD40-luciferase assay in BL2 cells. by Gang Li (34549)

“…(E) Titration of IKK inhibitor VII leads to inhibition of luciferase activity following tCD40L activation. …”

Neural lamella remodeling is needed for macrophage invasion. by Bente Winkler (20760273)

“…(<b>C</b>) Panglial expression of <i>Pvf2</i> and concomitant knockdown of <i>STAT92E</i> decreases the number of invaded macrophages by ~ 10-fold. …”

<i>cbf11</i> interacts genetically with <i>sty1</i> and <i>pka1</i> pathways. by Martin Převorovský (209870)

“…<b>(C)</b> Calcofluor staining documents that the occurrence of <i>Δcbf11</i>-associated septation defects (e.g., single cells with multiple septa) is decreased in the double mutants with <i>sty1</i> and <i>pka1</i>. …”

Effects of GHS on sarcoplasmic reticulum (SR) Ca²⁺ content and phospho-phospholamban (p-PLB)/phospholamban (PLB) expression. by Yi Ma (167857)

“…(D) The time-to-90% decay of caffeine-induced increases in [Ca²⁺]_i mainly reflect the Ca²⁺ clearance ability of the Na⁺/Ca²⁺ exchanger (NCX). n  =  18, 44, 44, 33, 38, 41 and 38 cells/3 mice in G post control, control, ischemia, G pre, G post, H pre and H post, respectively. (E) Representative western blots of the total phospholamban (PLB) and the phosphorylated PLB (p-PLB) in 6 groups and (F) the densitometric quantification of ratio of p-PLB/PLB (expressed as fold increase relative to control). n  =  5 mice in each group. …”

Characterization of the Autophagy Marker Protein Atg8 Reveals Atypical Features of Autophagy in <i>Plasmodium falciparum</i> by Rahul Navale (452742)

“…Starvation, the best known autophagy inducer, decreased PfAtg8 level by almost 3-fold compared to the normally growing parasites. …”

Patterns of differential gene expression levels of candidate genes post infection in susceptible and resistant strains. by Nourtan F. Abdeltawab (89435)

“…<p>Quantitative PCR results showing levels of gene expression of 14 genes with significant (P = 0.05–0.08) change post-infection in susceptible and resistant strains, expressed as Log fold differences in gene expression level post-infection. …”

Time-Dependent Decay of mRNA and Ribosomal RNA during Platelet Aging and Its Correlation with Translation Activity by Catherine Angénieux (145933)

“…To attempt to solve this paradox, we studied changes in the RNA content of reticulated platelets, i.e., young cells brightly stained by thiazole orange (TO^bright), a fluorescent probe for RNAs. …”

The extracellular matrix proteoglycan fibromodulin is upregulated in clinical and experimental heart failure and affects cardiac remodeling by Kine Andenæs (5566217)

“…Although collagen amount and cross-linking were comparable in FMOD-KO and wild-type, overexpression of fibromodulin in cardiac fibroblasts <i>in vitro</i> decreased their migratory capacity and expression of fibrosis-associated molecules, i.e. the collagen-cross linking enzyme lysyl oxidase, transglutaminase 2 and periostin. …”

Elimination of <i>tp53</i> function partially rescues <i>tert^−/−</i> degeneration in proliferative tissues. by Catarina M. Henriques (102294)

“…Data are represented as mean +/− SEM. Scale bar = 50 µm.</p>…”

Adult lifespan in nickel-spiked sediment – survivorship curves. by David Rudel (467731)

“…<p>Recovery of <i>Cel-fog-2</i> females from WB spiked nickel sediments, WB-0 (blue circles), WB-2 (green triangle), WB-3 (black asterisks), and WB-5 (red squares). Survivability decreases as nickel increases. Yellow-orange dotted line represents a 50% recovery. …”

Image5_Effect of Rumex dentatus on Gastrointestinal Protection and Toxicology in Rodents via Investigating H+/K+-ATPase, Calcium Channels, and PDE Mediated Signaling.tiff by Neelam Gul Qazi (13178827)

“…Extracts and emodin also show an inhibitory effect against H⁺/K⁺-ATPase. Rumex dentatus showed a gastroprotective and antioxidant effect. Histopathological evaluation showed improvement in cellular architecture and decrease in the expression of inflammatory markers such as cyclooxygenase (COX2), tumor necrosis factor (TNF-α), and phosphorylated nuclear factor kappa B (p-NFƙB), validated through immunohistochemistry, ELISA, and western blot techniques. …”

Increased BMP/TGFB signaling pathway activity in <i>Rx > cre Myrf</i>^<i>fl/fl</i> mutants. by Michelle L. Brinkmeier (18709048)

“…(C-<i>Myrf</i>^<i>fl/fl</i>; M-<i>Rx > cre Myrf</i>^<i>fl/fl</i>) (B) VlnPlot representation of transcript levels of <i>Wfikkn2</i>, <i>Tgfb2,</i> and <i>Id3</i> in theRPE cluster highlighting a decrease in the pathway inhibitor, <i>Wfikkn2</i> and increases in <i>Tgfb2</i> and <i>Id3</i>. …”

Image1_Effect of Rumex dentatus on Gastrointestinal Protection and Toxicology in Rodents via Investigating H+/K+-ATPase, Calcium Channels, and PDE Mediated Signaling.tiff by Neelam Gul Qazi (13178827)

“…Extracts and emodin also show an inhibitory effect against H⁺/K⁺-ATPase. Rumex dentatus showed a gastroprotective and antioxidant effect. Histopathological evaluation showed improvement in cellular architecture and decrease in the expression of inflammatory markers such as cyclooxygenase (COX2), tumor necrosis factor (TNF-α), and phosphorylated nuclear factor kappa B (p-NFƙB), validated through immunohistochemistry, ELISA, and western blot techniques. …”

<i>Spidey</i> expression during development is essential for adult survival. by Yin Ning Chiang (1718815)

“…Survival % is calculated as the number of successfully eclosed adults relative to the total number of male and female embryos; E: embryo; L1: 1^st instar larvae; L2: 2^nd instar larvae; L3: 3^rd instar larvae; P: pupae. N = 50 embryos for each stage. See <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1006126#pgen.1006126.s012" target="_blank">S6 Table</a> for full genotypes. …”

Effect of Intramuscular Injection of pH, lactate, ATP, and α,β–meATP on Muscle Withdrawal Threshold. by Nicholas S. Gregory (796912)

“…<p>Muscle withdrawal threshold was measured before and 30 minutes after injection of physiologic and supraphysiologic concentrations of pH, lactate, ATP, and α,β–meATP. (A) pH dose response curve. Rats were injected with normal saline adjusted to neutral pH (n = 6), pH 4.0 (n = 12), pH 4.5 (n = 6), pH 5.0 (n = 6), and pH 6.0 (n = 6). …”

Table1_Effect of Rumex dentatus on Gastrointestinal Protection and Toxicology in Rodents via Investigating H+/K+-ATPase, Calcium Channels, and PDE Mediated Signaling.docx by Neelam Gul Qazi (13178827)

“…Extracts and emodin also show an inhibitory effect against H⁺/K⁺-ATPase. Rumex dentatus showed a gastroprotective and antioxidant effect. Histopathological evaluation showed improvement in cellular architecture and decrease in the expression of inflammatory markers such as cyclooxygenase (COX2), tumor necrosis factor (TNF-α), and phosphorylated nuclear factor kappa B (p-NFƙB), validated through immunohistochemistry, ELISA, and western blot techniques. …”

Table_1_Integrative Brain Transcriptome Analysis Reveals Region-Specific and Broad Molecular Changes in Shank3-Overexpressing Mice.XLSX by Chunmei Jin (5705060)

“…We also re-analyzed previously reported RNA-sequencing results of the striatum of adult Shank3 TG mice and of the prefrontal cortex of juvenile Shank3^+/^Δ^C mice with a 50–70% reduction of Shank3 proteins. We found that several myelin-related genes were significantly downregulated specifically in the mPFC, but not in the striatum or hippocampus, of adult Shank3 TG mice by comparing the differentially expressed genes (DEGs) of the analyses side by side. …”

Table2_Effect of Rumex dentatus on Gastrointestinal Protection and Toxicology in Rodents via Investigating H+/K+-ATPase, Calcium Channels, and PDE Mediated Signaling.docx by Neelam Gul Qazi (13178827)

“…Extracts and emodin also show an inhibitory effect against H⁺/K⁺-ATPase. Rumex dentatus showed a gastroprotective and antioxidant effect. Histopathological evaluation showed improvement in cellular architecture and decrease in the expression of inflammatory markers such as cyclooxygenase (COX2), tumor necrosis factor (TNF-α), and phosphorylated nuclear factor kappa B (p-NFƙB), validated through immunohistochemistry, ELISA, and western blot techniques. …”