Image2_Total flavonoids extracted from Penthorum chinense Pursh mitigates CCl4-induced hepatic fibrosis in rats via inactivation of TLR4-MyD88-mediated NF-κB pathways and regulatio... by Sujuan Wang (1865149)

“…Subsequently, rats were randomly assigned to a control group (Control), a carbon tetrachloride (CCl₄)-induced hepatic fibrosis model group (Model), a positive control group [0.2 mg/(kg∙day)] of Colchicine), and three TFPCP treatment groups [50, 100, and 150 mg/(kg∙day)]. …”

Basal PLD activity is strongly stimulated by the D1/5R agonist and blocked by the D1/5R, mGluR5, mGluR1, and the PLD-linked mGluR antagonists in the amygdala of cocaine CPP animals... by Balaji Krishnan (203728)

“…The D1/5R antagonist, SCH23390, completely blocked basal PLD activity (91.2±21.9, n = 12, ^##<i>p</i><0.01) in the cocaine CPP group. A similar reduction in PEtOH levels was observed with application of either the PLD-linked mGluR antagonist, PCCG-13 (62.9±10.6, n = 7, ^##<i>p</i><0.01) or the mGluR1 antagonist, LY367385 (75.0±13.9, n = 12, ^##<i>p</i><0.01), while the mGluR5 antagonist, MPEP, did not decrease basal PLD activity (305.7±31.5, n = 7, ns) within the cocaine CPP group but were significantly increased compared to (*<i>p</i><0.05) the saline treated group. …”

Image_1_Archetypal type II and III Toxoplasma gondii oocysts induce different immune responses and clinical outcomes in experimentally infected piglets.tif by Andrea Largo-de la Torre (13985607)

“…Apathy and a moderate decrease in feed consumption were observed in G1 and G2 piglets between 5 and 8 dpi, coinciding with fever (>40°C). …”

Endocycle is required for ecdysone biosynthesis. by Yuya Ohhara (3697570)

“…<p><b>(A)</b> Knockdown of <i>CycE</i> in the PG causes reduction in DNA content. …”

Siglec-1 expressed in LPS mDCs capture distinct ganglioside containing vesicles, such as HIV-1 viral-like particles, liposomes, and exosomes. by Nuria Izquierdo-Useros (91232)

“…(D) Capture of VLP_HIV-Gag-eGFP by LPS mDCs that had been pre-incubated with decreasing concentrations of α-Siglec-1 mAb 7D2 before VLP exposure for 30 min at 37°C. …”

Pattern convergence via scaling in single granule cells. by Antoine D. Madar (6619286)

“…<i>Left and Middle</i>: Mean+/-SEM. Blue indicates a significant difference from the identity line (one-sample t-test, p < 0.05). …”

Effect of tradeoff strength on equilibrium <i>X</i> for different antibiotic treatments. by Ellsworth M. Campbell (313943)

“…We note here that if <i>π</i> = 1, <i>Xˆ</i> values in both treatments became indistinguishable from those in MIXING with <i>π</i> = 50 and for all sampled values of <i>ω</i>. If π was increased above 50, <i>Xˆ</i> values in CYCLING converged downwards to match those in SINGLE, while in MIXING they decreased to match those in CYCLING (<i>π</i> = 50). …”

Coronary artery disease is associated with an altered gut microbiome composition by Takumi Toya (690584)

Fluorescence Linked Enzyme Chemoproteomic Strategy for Discovery of a Potent and Selective DAPK1 and ZIPK Inhibitor by David A. Carlson (1867249)

Developing an efficient protocol for monitoring eagle fatalities at wind energy facilities by Eric C. Hallingstad (6078380)

“…Using these estimates and assuming a 30-day search interval for all facility turbines, we estimated that the probability of detecting a large raptor carcass using the scanning search method at a wind facility ranged from 0.50 to 0.69. …”

<i>Brn3b</i> regulates expression of <i>Tac2</i> in the deep SC/PAG. by Hyoseo Lee (17419987)

“…<b>(D)</b> Schematic diagram of the brain area analyzed for <i>Tac2</i> expression in a coronal section (top) and a sagittal image depicting the level (dashed line) where the coronal section was acquired (bottom). <b>(E, F)</b> <i>Brn3b</i> deletion decreased <i>Tac2</i> expression (red) in the deep SC/PAG, as detected by in situ hybridization. …”

Evidence for changed homeostasis of T_regs in children with high malaria exposure. by Michelle J. Boyle (204737)

“…<i>falciparum</i> infected RBCs (PfSE) or uninfected RBCs (uE). T_reg frequencies were enumerated (FoxP3+CD25+CD127^dim) and induction factor was calculated based on frequency fold change between PfSE and uE stimulated PBMCs. …”

Characteristics of myopic and hyperopic eyes in patients with antimetropia by Furkan Kirik (12659855)

“…<p>Antimetropia is a rare type of anisometropia in which one eye is myopic and the fellow is hyperopic, This optical condition condition permits the evaluation of both sides of the emmetropisation process failure in the same individual by minimising genetic and environmental factors.…”

Endoglin deletion in MΦ impairs phagocytosis. by Luisa Ojeda-Fernández (2580325)

“…Data were normalized to <i>Eng</i>^<i>wt/wt</i><i>LysMCre</i> mice and presented as the mean ± SEM. Results are pooled from 3 independent experiments with each experiment performed in duplicate; data was analyzed versus respective controls using a Student’s <i>t test</i> (N = 3). …”

Electroporation of cDNA/Morpholinos to targeted areas of embryonic CNS in -2 by Julien Falk (83075)

“…Note that the density of cells (DAPI) is lower laterally. d: Histograms showing decreases in the fraction of cells transfected in the superficial third of the brain when embryos were electroporated at stage 32 as compared to stage 28. e: A cluster of superficially located cells can be selectively transfected by injecting the DNA solution under the skin (the pia and epidermis are outlined in white). f-h: Time course of GFP expression in embryos electroporated at stage 29/30 (20 V/25 ms/1 s/8 x). …”

Loss of spermatogonia and wide-spread DNA methylation defects in newborn male mice deficient in DNMT3L-5 by Sophie La Salle (74593)

“…The methylation level of a given locus was compared to the regional GC content of 50kb of flanking sequence; the GC content of a region was characterized as being "low" or "high" if it was, respectively, below or above the average GC content of the analyzed chromosome. …”

Figure 5 by Thomas B. Nicholson (406800)

“…(A) Lsd1 mRNA levels were decreased by approximately 50%, confirming the microarray data. …”

Data Sheet 1_Global respiratory tumor mortality correlation study with economic level, 2000–2019.docx by Mingjie Wang (1719895)

“…</p>Results<p>The core cohort included 50 countries with sufficient data. The global mean ASMR for respiratory cancers showed a decreasing trend from 2000 to 2019. …”

Figure 5 by Victor M. Rodriguez-Molina (379001)

“…Inset shows results for EPSPs 0.1/1 and 0.3/3 drawn on a larger scale. The addition of background noise had similar effects on fast and slow EPSCs, with the exception of EPSPs with τ_rise/τ_decay 0.1/8 ms, which produced similar STPs under all three conditions (ANOVA, <i>p</i>>0.05) and τ_rise/τ_decay 1/20 ms, which showed decreased STP under noise conditions (<i>p</i><0.05), but no difference in STP between the noise and pre-noise condition (<i>p</i>>0.05). …”

Double fluorescence study by flow cytometry of CD45RO lymphocytes subpopulations and apoptosis by CD8⁺CD25⁺ regulatory T cells during IVMP. by Yi-Giien Tsai (514981)

“…(c). siRNA of FoxP3 decreased granzyme B protein expression in CD8⁺CD25⁺ Treg cells if pretreated with nucleosomal histone peptide epitope (H3:115–135) and dexamethasme (50 nM). …”