DataSheet1_Extracts of Andrographis paniculata (Burm.f.) Nees Leaves Exert Anti-Gout Effects by Lowering Uric Acid Levels and Reducing Monosodium Urate Crystal-Induced Inflammation... by Eldiza Puji Rahmi (8584506)

“…In the XO inhibitory activity, none of the samples exhibited greater than 50% inhibition. However, in a rat model, EtOH80 extract (200 mg/kg/day) and andrographolide (30 mg/kg/day) decreased serum uric acid levels and reduced liver XO activity, reduced the protein expression levels of URAT1 and GLUT9, and restored the decrease in OAT1 levels. …”

Three Generic Nevirapine-Based Antiretroviral Treatments in Chinese HIV/AIDS Patients: Multicentric Observation Cohort by Taisheng Li (269024)

“…In planned subgroup analyses, the decrease of viral response rate was seen in group A when CD4 cell count >200/ul (subgroup H). …”

DataSheet1_Extracts of Andrographis paniculata (Burm.f.) Nees Leaves Exert Anti-Gout Effects by Lowering Uric Acid Levels and Reducing Monosodium Urate Crystal-Induced Inflammation... by Eldiza Puji Rahmi (8584506)

“…In the XO inhibitory activity, none of the samples exhibited greater than 50% inhibition. However, in a rat model, EtOH80 extract (200 mg/kg/day) and andrographolide (30 mg/kg/day) decreased serum uric acid levels and reduced liver XO activity, reduced the protein expression levels of URAT1 and GLUT9, and restored the decrease in OAT1 levels. …”

Validation of ALDH1A3 as target of miR-187. by Irene Casanova-Salas (738137)

“…Data are presented relative to the vector control assigned a value of 100. The mean ± s.e.m. of three independent experiments is shown. …”

Table_1_The hidden financial catastrophe of chronic kidney disease under universal coverage and Thai “Peritoneal Dialysis First Policy”.DOCX by Pornpen Sangthawan (13952118)

“…The “PD First' program” could serve as a model for other LMICs. However, strategies to minimize financial distress should be further developed, especially for the poor.…”

Image_1_Immune Protective Evaluation Elicited by DNA Vaccination With Neospora caninum Dense Granules Proteins in Mice.TIF by Guili Yu (10201136)

“…The immune protective efficacy revealed that pcNcGRA4, pcNcGRA14, and pcNcGRA17 DNA vaccines could individually increase the survival rate to 50, 37.5, and 25% in comparison with 0% in the control group; prolong the survival time more than 20.88 ± 11.12, 18.88 ± 10.83, and 16.63 ± 10.66 days compared with the control group of 4 ± 1.31 days; and decrease parasite burden in the brains to 297.63 ± 83.77, 471.5 ± 110.74, and 592.13 ± 102.2 parasites/100 ng comparing with 1221.36 ± 269.59 parasites/100 ng in the control group. …”

Global burden of maternal and congenital syphilis and associated adverse birth outcomes—Estimates for 2016 and progress since 2012 by Eline L. Korenromp (157311)

“…To assess progress towards the goal of <50 CS cases per 100,000 live births, we generated regional and global estimates of maternal and congenital syphilis for 2016 and updated the 2012 estimates.…”

DataSheet_1_Potential Role of Macrophage Phenotypes and CCL2 in the Pathogenesis of Takayasu Arteritis.doc by Xiufang Kong (3821644)

“…</p>Methods<p>In this study, 74 patients with TA and 50 controls were recruited. TA disease activity was evaluated with Kerr scores. …”

Diel thermal cycles induce fungal growth rings in culture. by Kathryn Jacobson (739677)

“…<p><i>Chaetomium strumarium</i> grown in the dark at optimal growth temperature (40⁰C) (7a); and with Namib diel sand-surface thermal cycle (15–50⁰C) (7b): 1 hour increments of increasing temperature from 20–45°C, 50°C for 5 hours, 1-hour increments of decreasing temperature from 45–25°C, and 20°C for 6 hours.…”

Table_1_Effect of fermented heat-treated rice bran on performance and possible role of intestinal microbiota in laying hens.DOCX by Yamei Wang (9198787)

“…To investigate the effects of dietary supplementation with fermented heat-treated rice bran on the performance, apparent digestibility of nutrients, cecal microbiota and metabolites in laying hens, a total of 128 18-week-old Hy-Line brown layers were randomly assigned to four treatment groups: 2.5% HRB (basal diet contained 2.5% heat-treated rice bran), 5.0% HRB (5.0% heat-treated rice bran), 2.5% FHRB (2.5% fermented heat-treated rice bran), 5.0% FHRB (5.0% fermented heat-treated rice bran). …”

Optimisation of read depth, DNA quantity, and unique alternate observation threshold. by Melinda L. Tursky (20790436)

“…<p>A: The detection rate of reference standard variants ranging from 0.0008 to 0.1 VAF at 500-5,000 × depth. …”

Partial repartitioning of the NST-adjoining TADs across membranes into the cyto/nucleoplasm. by Yiguo Zhang (512679)

“…The results are shown graphically (<i>c,</i> mean ± S.D, n = 4), allowing the stability of different Nrf1 mutants in membrane PK protection reactions to be compared (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0093458#pone.0093458.s004" target="_blank">Figure S4</a>). …”

Data Sheet 1_Chemopreventive and therapeutic effects of Hippophae rhamnoides L. fruit peels evaluated in preclinical models of breast carcinoma.docx by Dana Dvorska (19809111)

“…In the 4T1 mouse model, seaberry treatment resulted in a significant, dose-dependent reduction in tumor volume (43% and 48% compared to controls) and a decrease in the mitotic activity index. …”

Sperm beat frequency and CA-activity in CA ^−/− mice. by Petra M. Wandernoth (149629)

“…<b>B</b>, Sperm of CA IV^−/− mice show a decreased response to HCO₃⁻. …”

<strong>Long-term effectiveness of the national diabetes quality assessment program in South Korea</strong> by Ji Hye Huh (528817)

“…Each achievement of quality assessment indicator was associated with a decreased risk of diabetes complications and all-cause mortality. …”

Quantitative Analysis of the Extracellular Response Kinase 1 and 2 (ERK1/2), Calcium-Calmodulin Kinase II (CAMKII), Fragile X Protein (FMRP), and the Nicotinic Acetylcholine Recept... by Robert K. Naviaux (256148)

“…<p>(A) ERK1 (MAPK3) and ERK2 (MAPK1) phosphorylation was decreased by over 90% by gestational poly(IC) exposure and normalized by suramin treatment (Sal-Sal = 100+/−5%; Sal-Sur = 6.2+/−0.8%; PIC-Sal = 9.9+/−2.6%; PIC-Sur = 84+/−2.3%; one-way ANOVA F(3,12) = 241; p<0.0001; n = 4–5 males per group; age = 16 weeks). …”

Constitutively nuclear Foxo1 reduced Na_V1.5 expression. by Weike Mao (181121)

“…<p>Western blots showed that overexpression of Foxo1-AA-GFP for 36 hours reduced Na_V1.5 protein level while it increased endogenous Foxo1 expression (A); quantitiation of Na_V1.5 protein level relative to GAPDH revealed that expression of Foxo1-AA-GFP (n = 5) significantly decreased (*p<0.05, at 10 MOI; **p<0.01 at 50 MOI) Na_V1.5 expression compared with 50 MOI GFP (n = 5) (C). …”

Overexpression of Pde2p can diminish the transcriptional response to mtDNA deletion. by Emel Akdoğan (844906)

“…<i>ARO9</i> and <i>ARO10</i> were selected after a more than three-fold (q < 0.05) reduction in expression when comparing <i>ρ</i>^<i>0</i> cells to <i>ρ</i>^<i>+</i> cells containing vector pRS426. …”

Figure 3 from Synergistic Effects of PARP Inhibition and Cholesterol Biosynthesis Pathway Modulation by Anna Rutkowska (19676837)

“…Mean fold changes (<i>n</i> = 3) and adjusted <i>P</i> values from one representative experiment are shown. …”

Optimization of the effect of rISL1 protein on hESCs. by Hananeh Fonoudi (278175)

“…The percentage of beating clusters in the rISL1-treated group was significantly higher than the untreated group at day 14 after plating (75±10% vs. 20±2.5%). )* : P<0.05((F) rISL1 treatment resulted in a 3.2±0.5 fold increase in the number of beating areas in comparison with untreated control group. rISL1 also caused a 2.2±0.4 fold increase in the other hESC line, Royan H6, which shows the reproducibility of this protocol for another hESC line. )* : P<0.05((G) In order to assess the expression of cardiac-specific genes, we collected samples at 3 stages: day 3 after plating (the day of rISL1 removal); day 14 after plating (day of maximum beating); and day 20 after plating (day that beating decreased and cells were mature) by qRT-PCR in two hESC lines. …”