Reduction of <i>cad</i> expression in ISCs and progenitor cells represses age-associated gut hyperplasia in <i>Drosophila</i>. by Kun Wu (286745)

“…Ultimately, this leads to a decrease of differentiation efficiency of ISCs and EBs with age, which, in turn, results in gut hyperplasia as indicated by the continuous accumulation of ISCs and their differentiating progenies (i.e., <i>esg</i>⁺ polyploid cells) in the midguts of aged <i>Drosophila</i>. …”

Image_2_Reciprocal Relationship Between HDAC2 and P-Glycoprotein/MRP-1 and Their Role in Steroid Resistance in Childhood Nephrotic Syndrome.tif by Harshit Singh (6724346)

“…Compared to baseline, TSA treatment increased mRNA levels of P-gp and MRP-1 (fold change 7.51, 7.31, ^*p < 0.0001 in SRNS) and (fold change 3.49, 3.35, ^*p < 0.0001 in SSNS), respectively. It significantly decreased the level of HDAC2 (fold change 1.50, ^*p < 0.0001 in SRNS) (fold change 2.53, ^*p < 0.0001 in SSNS) patients.…”

Image_4_Reciprocal Relationship Between HDAC2 and P-Glycoprotein/MRP-1 and Their Role in Steroid Resistance in Childhood Nephrotic Syndrome.tif by Harshit Singh (6724346)

“…Compared to baseline, TSA treatment increased mRNA levels of P-gp and MRP-1 (fold change 7.51, 7.31, ^*p < 0.0001 in SRNS) and (fold change 3.49, 3.35, ^*p < 0.0001 in SSNS), respectively. It significantly decreased the level of HDAC2 (fold change 1.50, ^*p < 0.0001 in SRNS) (fold change 2.53, ^*p < 0.0001 in SSNS) patients.…”

Image_3_Reciprocal Relationship Between HDAC2 and P-Glycoprotein/MRP-1 and Their Role in Steroid Resistance in Childhood Nephrotic Syndrome.tif by Harshit Singh (6724346)

“…Compared to baseline, TSA treatment increased mRNA levels of P-gp and MRP-1 (fold change 7.51, 7.31, ^*p < 0.0001 in SRNS) and (fold change 3.49, 3.35, ^*p < 0.0001 in SSNS), respectively. It significantly decreased the level of HDAC2 (fold change 1.50, ^*p < 0.0001 in SRNS) (fold change 2.53, ^*p < 0.0001 in SSNS) patients.…”

Image_1_Reciprocal Relationship Between HDAC2 and P-Glycoprotein/MRP-1 and Their Role in Steroid Resistance in Childhood Nephrotic Syndrome.tif by Harshit Singh (6724346)

“…Compared to baseline, TSA treatment increased mRNA levels of P-gp and MRP-1 (fold change 7.51, 7.31, ^*p < 0.0001 in SRNS) and (fold change 3.49, 3.35, ^*p < 0.0001 in SSNS), respectively. It significantly decreased the level of HDAC2 (fold change 1.50, ^*p < 0.0001 in SRNS) (fold change 2.53, ^*p < 0.0001 in SSNS) patients.…”

<i>Theileria annulata</i> parasites with M128I mutation in cytochrome B (<i>Ta</i>M128I) resist buparvaquone treatment. by Shahin Tajeri (3609266)

“…A clear right shift in dose-response curve resulted from decreased susceptibility of macrophages transformed by <i>Ta</i>M128I parasite compared to the wild type is detectable. …”

DataSheet2_Exploring pyrrolidinyl-spirooxindole natural products as promising platforms for the synthesis of novel spirooxindoles as EGFR/CDK2 inhibitors for halting breast cancer... by Mohamed S. Nafie (9754305)

“…Conversely, compounds 5a-f displayed promising cytotoxicity against MCF-7 cells with IC₅₀ values range (IC₅₀ = 5.87–18.5 μM) with selective activity against MDA-MB-231 cancer cells. …”

DataSheet1_Exploring pyrrolidinyl-spirooxindole natural products as promising platforms for the synthesis of novel spirooxindoles as EGFR/CDK2 inhibitors for halting breast cancer... by Mohamed S. Nafie (9754305)

“…Conversely, compounds 5a-f displayed promising cytotoxicity against MCF-7 cells with IC₅₀ values range (IC₅₀ = 5.87–18.5 μM) with selective activity against MDA-MB-231 cancer cells. …”

RFX1 is involved in Spata4 mediated cell growth. by Junjun Jiang (188208)

“…<p>(<b>A</b>) The protein level of RFX1 was decreased while Spata4 was increased in a time-dependent manner with RFX1-siRNA transfection in TM4 cells. …”

METH preconditioning enhanced Akt but not JNK activation in response to 6-OHDA. by Amina El Ayadi (341955)

Study of the properties of conventional concrete with additive or addition of water for consistency correction by Lucas Damas Maciel (10472736)

“…The results obtained indicate that in the reference stroke there was minimization of consistency in 64% over the 150 minutes. The mean compressive strength decreased over time, while water was added. …”

YorkU.forest.Oct5-2016 by Amrit Virdi (3130035)

“…</p><p><b>Abundance.woody.plants: </b>The total number of individual woody plants located within 0.5 meters of the 50m transect tape. A woody plant was defined as a tree that was over 1.5m in height. …”

3D motility of the Δ<i>phil1</i> parasites. by Jacqueline M. Leung (120235)

“…The Δ<i>phil1</i> parasites also exhibited significantly decreased mean velocity compared to the RH parasites (<b>E</b>) and significantly reduced maximum velocity compared to both RH and Comp parasites (<b>F</b>) (paired t-test, significance indicated by asterisks). …”

Hdc expression is controlled by InR/mTOR signalling and <i>unk</i>. by Amélie Avet-Rochex (628552)

“…(G, G′) Hdc expression (red) is decreased in a <i>Rheb^2D1</i> mutant clone (arrow). …”

Effect of carabrone on mitochondrial respiratory chain complex V (ATP synthase). by Xingyu Ren (7358867)

“…<b>(B)</b> Measurement of mitochondrial membrane potential (MMP, Δ<i>Ψ</i>m) in <i><i>G. tritici</i></i>, treatment by carabrone (50 and 100 μM), FCCP (250 nM) and oligomycin A (5 nM), JC-1 monomers (green) indicate decreased MMP, JC-1 aggregates (red) indicate increased MMP, Bar = 100 μm. …”

Neuronal loss in the spiral and vestibular ganglia in <i>Slitrk6</i>-deficient mice. by Kei-ichi Katayama (257931)

“…Both the number of neurons and volume of the spiral ganglion of <i>Slitrk6</i>-knockout mice were significantly lower than those of wild-type mice at E16.5, and they decreased to about a half of those of wild-type mice at P0 (A, B). …”

Image_1_Remarkable impacts of probiotics supplementation in enhancing of the antioxidant status: results of an umbrella meta-analysis.pdf by Vali Musazadeh (12304682)

“…Subgroup analyses were carried out based on supplementation dosage and duration, mean age, and study population.</p>Results<p>Our results indicated that probiotics supplementation meaningfully decreased serum malondialdehyde (MDA) (ES_WMD = −0.56, 95% CI: −0.72, −0.39; p < 0.001, and ES_SMD = −0.50, 95% CI: −0.66, −0.34; p < 0.001). …”

Image_1_Remarkable impacts of probiotics supplementation in enhancing of the antioxidant status: results of an umbrella meta-analysis.pdf by Vali Musazadeh (12304682)

“…Subgroup analyses were carried out based on supplementation dosage and duration, mean age, and study population.</p>Results<p>Our results indicated that probiotics supplementation meaningfully decreased serum malondialdehyde (MDA) (ES_WMD = −0.56, 95% CI: −0.72, −0.39; p < 0.001, and ES_SMD = −0.50, 95% CI: −0.66, −0.34; p < 0.001). …”

Effect of PPARγ modulation on PUVA-induced expression of senescence-like phenotype in HDFs. by Stefania Briganti (610869)

“…Scale bar 50 µm. (B) SA-β-gal expression was detected as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0104045#s2" target="_blank"><b>Materials and Methods</b></a>. …”

Diagnosis noma study Anka General Hospital 2021. by Elise Farley (4915459)

“…<div><p>Introduction</p><p>Noma is a rapidly spreading infection of the oral cavity which mainly affects young children. …”