The Effect of Rosuvastatin in a Murine Model of Influenza A Infection by Kathryn A. Radigan (169555)

“…<div><h3>Rationale</h3><p>HMG-CoA reductase inhibitors such as rosuvastatin may have immunomodulatory and anti-inflammatory effects that may reduce the severity of influenza A infection. We hypothesized that rosuvastatin would decrease viral replication, attenuate lung injury, and improve mortality following influenza A infection in mice.…”

Receptor for Advanced Glycation End-Products Signaling Interferes with the Vascular Smooth Muscle Cell Contractile Phenotype and Function by Elie Simard (481523)

“…We demonstrated that RAGE is expressed and functional in the A7r5 VSMC model, and its activation by AGE significantly increased NF-κB activity, which is known to interfere with the contractile phenotype of VSMC. …”

DataSheet_1_Chronic stress induces meiotic arrest failure and ovarian reserve decline via the cAMP signaling pathway.docx by Yiwen Jiang (6697760)

“…<p>Chronic stress is suspected to be a causal factor of female subfertility; however, the underlying mechanisms remain unclear. Here, we found that chronic stress inhibited the cyclic adenosine 3′,5′-monophosphate (cAMP) signaling pathway, leading to ovarian reserve decline in mice. …”

Data_Sheet_1_Network Modeling of Liver Metabolism to Predict Plasma Metabolite Changes During Short-Term Fasting in the Laboratory Rat.ZIP by Kalyan C. Vinnakota (43374)

“…We then measured plasma metabolite profiles in rats fasted for 5–7 or 10–13 h to test our model predictions. …”

Image_1_Integrated single-cell transcriptome analysis of the tumor ecosystems underlying cervical cancer metastasis.jpeg by Chunbo Li (167815)

“…Finally, we demonstrated that cancer-associated fibroblasts (CAFs) in P-LN were associated with immune regulation, while CAFs in tumor underwent EMT. …”

Data Sheet 4_Altered gut microbial networks and metabolic pathways in multiple system atrophy: a comparative 16S rRNA study.csv by Po-Chun Liu (676035)

“…Additionally, we identified an increase in the ARGORNPROST-PWY pathway (L-arginine degradation, q = 0.003) and a decrease in the PWY-6478 pathway (GDP-D-glycero-α-D-manno-heptose biosynthesis, q = 0.015) in MSA patients compared with HCs.…”

Nest design as an adaptative tool to escape brood parasitism by Angela Moreras (12024272)

“…Redstarts, on the other hand, reduced successful brood parasitism by placing nest cups further from the cavity entrance, but also selecting cavities with relatively smaller entrances. </p> <p>5. We show the importance of host nest design influencing the coevolution between hosts and brood parasites. …”

Image_9_Integrated single-cell transcriptome analysis of the tumor ecosystems underlying cervical cancer metastasis.jpeg by Chunbo Li (167815)

“…Finally, we demonstrated that cancer-associated fibroblasts (CAFs) in P-LN were associated with immune regulation, while CAFs in tumor underwent EMT. …”

Image_7_Integrated single-cell transcriptome analysis of the tumor ecosystems underlying cervical cancer metastasis.jpeg by Chunbo Li (167815)

“…Finally, we demonstrated that cancer-associated fibroblasts (CAFs) in P-LN were associated with immune regulation, while CAFs in tumor underwent EMT. …”

Data Sheet 1_Altered gut microbial networks and metabolic pathways in multiple system atrophy: a comparative 16S rRNA study.pdf by Po-Chun Liu (676035)

“…Additionally, we identified an increase in the ARGORNPROST-PWY pathway (L-arginine degradation, q = 0.003) and a decrease in the PWY-6478 pathway (GDP-D-glycero-α-D-manno-heptose biosynthesis, q = 0.015) in MSA patients compared with HCs.…”

Data_Sheet_2_Network Modeling of Liver Metabolism to Predict Plasma Metabolite Changes During Short-Term Fasting in the Laboratory Rat.ZIP by Kalyan C. Vinnakota (43374)

“…We then measured plasma metabolite profiles in rats fasted for 5–7 or 10–13 h to test our model predictions. …”

Exploring an animal model of amodiaquine-induced liver injury in rats and mice by Feng Liu (72874)

“…There was also an increase in serum IL-2, IL-5, IL-9, IL-12, MCP-1 and TGFβ, but a decrease in leptin. …”

Image_2_The Valproate Mediates Radio-Bidirectional Regulation Through RFWD3-Dependent Ubiquitination on Rad51.tif by Guochao Liu (10450499)

“…Here, using the 7,12-dimethylbenz[α]anthracene (DMBA)-induced malignant transformed MCF10A cells, we found that valproate (VPA), a histone deacetylase inhibitor (HDACi), radiosensitized transformed cells while alleviated IR-induced damage in normal cells at a safe dose (0.5 mM). …”

Image_1_Comparative Study Reveals Insights of Sheepgrass (Leymus chinensis) Coping With Phosphate-Deprived Stress Condition.TIF by Lingyu Li (2641144)

“…Together with less extent of lipid peroxidation of the thylakoid membranes and increased ROS scavenger enzyme activities in the leaves of Pi-deprived seedlings, we suggest that the decreased activity of ATP synthase in their thylakoids is the major cause of the greater reduction of photosynthetic efficiency than that of low-Pi stressed plants, leading to the least shoot growth and biomass production in L. chinensis.…”

Impact of post-dialysis calcium level on <i>ex vivo</i> rat aortic wall calcification by Daniel Azpiazu (4385854)

“…</p><p>Approach and results</p><p>At the end of haemodialysis, mean serum calcium levels were increased in 88% of paired pre-/post-dialysis samples, while mean serum phosphate and parathyroid hormone levels were decreased. …”

Data Sheet 1_Apheresis for the treatment of relapses in MS and NMOSD: reduced antibody reactivities, gene expression changes and potential clinical response indicators.pdf by Michael Hecker (51971)

“…Blood samples were collected immediately before and after therapy to isolate plasma or serum as well as immune cells. We then measured (1) concentrations of the immunoglobulin isotypes IgG, IgM and IgA, (2) antibody reactivities against 12 peptides derived from potential autoantigens and Epstein-Barr virus proteins, (3) frequencies of CD19⁺ B cells, CD3⁺ T cells and CD14⁺ monocytes, (4) transcriptome profiles of CD19⁺ B cells and CD4⁺ T cells and (5) mRNA levels of 7 cytotoxicity-related genes in CD4⁺ T cells. …”

Image_1_Subpopulation treatment effect pattern plot analysis: a prognostic model for distant recurrence-free survival to estimate delayed adjuvant chemotherapy initiation effect in... by Zaida Morante (9292533)

“…Kaplan-Meier plots showed that in the discovery set, patients with TTC>30 days experienced a 17.5% decrease in 10-year DRFS rate (95%CI=6.7-28.3), and the impact was more remarkable in patients who belong to the high-risk subgroup (53.3% decrease in 10 years-DRFS rate). …”

Pollen-based Holocene vegetation reconstruction.xlsx by Yuanhao Sun (12697028)

“…In the Daihai basin, the vegetation cover changed relatively little, maintaining values of 45–50%, and only increased during the interval of 8–5.1 ka, when it attained a maximum of 67%. …”

Data_Sheet_1_De novo Assembly of the Pokeweed Genome Provides Insight Into Pokeweed Antiviral Protein (PAP) Gene Expression.zip by Kira C. M. Neller (5170226)

“…Sequencing comprised paired-end reads from a short-insert library of 83X coverage, and our draft assembly (N50 = 42.5 Kb) accounted for 74% of the measured pokeweed genome size of 1.3 Gb. …”

Image_1_De novo Assembly of the Pokeweed Genome Provides Insight Into Pokeweed Antiviral Protein (PAP) Gene Expression.pdf by Kira C. M. Neller (5170226)

“…Sequencing comprised paired-end reads from a short-insert library of 83X coverage, and our draft assembly (N50 = 42.5 Kb) accounted for 74% of the measured pokeweed genome size of 1.3 Gb. …”