Immune Checkpoint Inhibitors and Risk of Type 1 Diabetes by Xuan Chen (158617)

“…Younger age (HR=1.19 for every 5-year decrease; 95% CI, 1.13-1.25) and pre-existing non-T1DM diabetes (HR=4.48; 95% CI, 3.45-5.83) were also associated with higher risk of ICI-T1DM. …”

Table 4_The burden and etiologies of diarrhea in Asia and its countries from 1990 to 2021 and the forecast to 2040: analyses informed by the global burden of disease study 2021.doc... by Shan Liu (193759)

“…</p>Results<p>Overall burden showed that the ASRs in Asia decreased from 1990 to 2021, with EAPCs of −0.40, −0.55, −5.70, and −5.47, respectively. …”

Asymptomatic fluid overload predicts survival and cardiovascular event in incident Chinese peritoneal dialysis patients by Jack Kit-Chung Ng (745481)

“…Fluid overload was present in 272 patients (87.5%) when defined as OH volume over 1.1L. All hydration parameters significantly correlated with Charlson Comorbidity Index, and inversely with total Kt/V, and serum albumin. …”

TLR7 Influences Germinal Center Selection in Murine SLE by Alexis Boneparth (707054)

“…In addition, although all chimeras preferentially selected 3H9/Vκ5 encoded B cells into the germinal center and plasma cell compartments, 3H9 male <i>Yaa</i> chimeras had a more diverse repertoire and positively selected the 3H9/Vκ5-48/Jκ4 pair that confers high affinity anti-cardiolipin activity. …”

Low Cardiac Output Leads Hepatic Fibrosis in Right Heart Failure Model Rats by Yoshitaka Fujimoto (849634)

“…Hepatic fibrosis ratio and serum hyaluronic acid, an index of hepatic fibrosis, were significantly increased in the PAB group than those in the control group (7.8±1.7 and 1.0±0.2%, P<0.01, 76.2±27.5 and 32.7±7.5 ng/ml, P<0.01). Notably, the degree of hepatic fibrosis significantly correlated a decrease in CO. …”

Nephroprotective Efficacy of RAS Blockade in Mice Carrying R140Q Podocin Mutation by Helga Denc (567951)

“…</p> <p>METHODS:In C57BL/6 mice with Nphs2Flox/R140Q/Cre+ genotype,hemizygosity for mutant podocin was induced by tamoxifen injection.Animals received combined high-dose ACE inhibition and AT1 receptor blockade(ramipril+candesartan 10mg/kg each,R+C)or remained untreated.Treatment was started either prophylactically(P)at time of induction or with a 4-week delay(D).Animals were either sacrificed after 5 wks(9 wks in D) or observed open-end.</p> <p>RESULTS:Induction of R140Q-podocin hemizygosity caused massive proteinuria peaking at 4 wks,followed by a gradual decrease as progressive renal failure developed.In the P animals,RAS blockade persistently inhibited proteinuria(13%of untreated animals at 4 wks,p<0.005).In the D group,proteinuria sharply decreased upon RAS blockade.Three-month survival was 31% in the untreated,67% in the D and 100% in the P group respectively(p<0.05).…”

Table 3_The burden and etiologies of diarrhea in Asia and its countries from 1990 to 2021 and the forecast to 2040: analyses informed by the global burden of disease study 2021.doc... by Shan Liu (193759)

“…</p>Results<p>Overall burden showed that the ASRs in Asia decreased from 1990 to 2021, with EAPCs of −0.40, −0.55, −5.70, and −5.47, respectively. …”

Data_Sheet_1_Chinese Home-Based Cardiac Rehabilitation Model Delivered by Smartphone Interaction Improves Clinical Outcomes in Patients With Coronary Heart Disease.PDF by Jing Ma (24574)

“…<p>Purpose: We evaluated the long-term effect of a smartphone-facilitated home-based cardiac rehabilitation (HBCR) model in revascularized patients with coronary heart disease (CHD) on major adverse cardiac events (MACE), and secondary outcomes, including safety, quality of life, and physical capacity.…”

Flowchart of the included study population. by Tim Alex Lindskou (6411278)

“…</p><p>Results</p><p>We included 18,971 chest pain patients, 33.9% (n = 6,430) were diagnosed with”Diseases of the circulatory system” followed by the non-specific R- (n = 5,288, 27.8%) and Z-diagnoses (n = 3,634; 19.2%). …”

Acridone Derivative 8a Induces Oxidative Stress-Mediated Apoptosis in CCRF-CEM Leukemia Cells: Application of Metabolomics in Mechanistic Studies of Antitumor Agents by Yini Wang (410389)

“…Herein, we report the use of an UPLC/Q-TOF MS metabolomic approach to study the effects of three compounds with structures optimized step-by-step, 9(10H)-acridone (A), 10-(3,5-dimethoxy)benzyl-9(10H)-acridone (I), and 8a, on CCRF-CEM leukemia cells and to shed new light on the probable antitumor mechanism of 8a. …”

The two-state model describes time-kill data. by Alexandro Rodríguez-Rojas (326213)

“…For an overview of the fitted parameters, see <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1009443#ppat.1009443.s018" target="_blank">S5 Table</a>.</p>…”

Supplementary Material for: Atypical COVID-19-related Acute Macular Neuroretinopathy with Progression resulting in Severe Vision Loss by Weinberger E.M (20394746)

“…Introduction: We review the clinical course of a patient with decreased vision in the setting of COVID-19 infection consistent with an atypical presentation of acute macular neuroretinopathy (AMN). …”

Serum stimulates PLY oligomer formation. by Kristin R. Wade (625971)

“…The decrease in emission intensity of D is dependent on the formation of the oligomer <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1004353#ppat.1004353-Harris1" target="_blank">[47]</a>. …”

H3 K36 Methylation Helps Determine the Timing of Cdc45 Association with Replication Origins by Fiona Pryde (263331)

Pathway schematic depicting changes that occurred in measured metabolites, gene expression, and enzymatic activities for central metabolism during the transition from succinate to... by Elizabeth Skovran (236606)

“…<p>A boxed gene/protein name indicates the activity of this enzyme was measured. …”

LC treatment selectively induces expression of p21^cip1 gene, mRNA and protein in cancer cells. by Hongbiao Huang (292949)

“…HepG2 cells were treated with LC (2.5, 5.0, 10 mM) for 24 h; cells were collected for gene expression profile analysis. …”

Inflammatory monocytes (IMs) are directly infected with <i>S</i>. Typhimurium and can present to antigen-specific CD4⁺ T cells. by Nancy Wang (770979)

“…I) CD4⁺ T cells were re-stimulated with decreasing APC to T cell ratio but without further addition of peptides, mean±SEM of three technical replicates are shown for each condition.…”

Toxic-Selenium and Low-Selenium Transcriptomes in <i>Caenorhabditis elegans</i>: Toxic Selenium Up-Regulates Oxidoreductase and Down-Regulates Cuticle-Associated Genes by Christopher J. Boehler (442283)

“…Relative to 0.1 mM Se treatment, culturing <i>C. elegans</i> at these Se concentrations resulted in 1.9, 9.7, 5.5, and 2.3%, respectively, of the transcriptome being altered by at least 2-fold. …”

Clinical and epidemiological profile of patients with hypertensive peak after Ahmed glaucoma valve implant by Flávia da Silva Vilas-Boas (5910116)

“…After 6 months of follow-up the mean IOP decreased (16.4 ± 6.74 mmHg), with 2.23 ± 1.45 medications. …”

Managing retrial queueing systems with boundedly rational customers by Yu Zhang (12946)