In combination with <i>Gem3</i>^<i>BART</i>, Gemin5 knockdown triggers lethality whereas a reduction in the gene copy number of Gemin5 provokes impaired flight. by Rebecca M. Borg (758474)

“…Gemin5 knockdown alone or <i>Gem3</i>^<i>BART</i> in combination with <i>Smn</i>^<i>X7</i> induce only a mild decrease in viability throughout adulthood. …”

Potent Metabolic Sialylation Inhibitors Based on C‑5-Modified Fluorinated Sialic Acids by Torben Heise (1507726)

“…Inhibition of the sialic acid biosynthesis may therefore hold considerable therapeutic potential. To effectively decrease the sialic acid expression, we synthesized C-5-modified 3-fluoro sialic acid sialyltransferase inhibitors. …”

DataSheet_5_A combined analysis of bulk and single-cell sequencing data reveals that depleted extracellular matrix and enhanced immune processes co-contribute to fluorouracil benef... by Shaowei Dong (9501322)

“…We found that depleted extracellular matrix (ECM) components such as capillary/stroma cells and enhanced immune processes such as increased number of M1 polarized macrophages/Memory T cells/Natural Killer T cells/B cells and decreased number of regulatory T cells are two important features relating to 5-FU beneficial responses in GC patients, especially in diffuse-type patients. …”

S1 Data - by Angélica González Maciel (18946369)

Data_Sheet_1_hsa-miR-3177-5p and hsa-miR-3178 Inhibit 5-HT1A Expression by Binding the 3′-UTR Region in vitro.doc by Xue Wu (317735)

“…Using the HEK-293, U87, SK-N-SH and SH-SY5Y cell lines, we determined the functional sequence of the 3′-UTR region of the HTR1A gene and predicted miRNA binding. …”

Mean value plots for the sum of interdigital angles (A and B) foot alignment (C and D) and foot depression (E and F) at midstance. by Mingna V. Zhuang (2657587)

Analgesic prescriptions received by patients before commencing the BOA model of care for osteoarthritis: a Swedish national registry study with matched reference and clinical guide... by Allan Abbott (6032138)

“…Since guideline publication, the proportion of the OA cohort having no dispensed prescription analgesics prior to non-pharmacological primary care intervention concordantly increased by 5.0% (95% CI 4.2–5.9). Furthermore, dispensed prescriptions concordantly decreased for non-selective NSAIDs –8.6% (CI –9.6 to –7.6), weak opioids –6.8% (CI –7.7 to –5.9), glucosamine –9.5% (CI –9.8 to –8.8). and hyaluronic acid –1.6% (CI –1.8 to –1.5) but discordantly increased for strong opioids 2.8% (CI 2.1–3.4) and glucocorticoid intra-articular injection for hip OA 2.1% (CI 1.0–3.1).…”

Table_1_SARS-CoV-2 Spike Protein Expression In Vitro and Hematologic Effects in Mice Vaccinated With AZD1222 (ChAdOx1 nCoV-19).docx by Richard Stebbings (210270)

“…There is limited evidence on whether COVID-19 vaccine-induced spike protein is similarly cleaved and on the immediate effects of vaccination on host immune responses or hematology parameters. We investigated vaccine-induced S1 subunit cleavage and effects on hematology parameters using AZD1222 (ChAdOx1 nCoV-19), a simian, replication-deficient adenovirus-vectored COVID-19 vaccine. …”

Table_3_SARS-CoV-2 Spike Protein Expression In Vitro and Hematologic Effects in Mice Vaccinated With AZD1222 (ChAdOx1 nCoV-19).docx by Richard Stebbings (210270)

“…There is limited evidence on whether COVID-19 vaccine-induced spike protein is similarly cleaved and on the immediate effects of vaccination on host immune responses or hematology parameters. We investigated vaccine-induced S1 subunit cleavage and effects on hematology parameters using AZD1222 (ChAdOx1 nCoV-19), a simian, replication-deficient adenovirus-vectored COVID-19 vaccine. …”

Table_2_SARS-CoV-2 Spike Protein Expression In Vitro and Hematologic Effects in Mice Vaccinated With AZD1222 (ChAdOx1 nCoV-19).docx by Richard Stebbings (210270)

“…There is limited evidence on whether COVID-19 vaccine-induced spike protein is similarly cleaved and on the immediate effects of vaccination on host immune responses or hematology parameters. We investigated vaccine-induced S1 subunit cleavage and effects on hematology parameters using AZD1222 (ChAdOx1 nCoV-19), a simian, replication-deficient adenovirus-vectored COVID-19 vaccine. …”

Image_1_SARS-CoV-2 Spike Protein Expression In Vitro and Hematologic Effects in Mice Vaccinated With AZD1222 (ChAdOx1 nCoV-19).pdf by Richard Stebbings (210270)

“…There is limited evidence on whether COVID-19 vaccine-induced spike protein is similarly cleaved and on the immediate effects of vaccination on host immune responses or hematology parameters. We investigated vaccine-induced S1 subunit cleavage and effects on hematology parameters using AZD1222 (ChAdOx1 nCoV-19), a simian, replication-deficient adenovirus-vectored COVID-19 vaccine. …”

Effect of Dox, RSV-Dox and Dox-RSV on NFAT 3 and NFAT5 expression. by Heba Samy Shoukry (4262239)

“…<p>(A&B) NFAT3 and NFAT5 expression was measured by RT-PCR. Dox treatment for 2 weeks significantly increased NFAT3 (A) and decreased NFAT5 (B), RSV supplementation along with Dox or after 2 weeks of Dox treatment prevented NFAT3 increase and NFAT5 decrease. ß-actin was used as internal control. …”

Table_5_The in vivo dsRNA Cleavage Has Sequence Preference in Insects.XLSX by Ruobing Guan (6063893)

“…We discovered that a large number of siRNAs were produced with GGU nucleotide residues at the 5′- and 3′-ends and produced a siRNA peak on the sequence. …”

S1 Raw data - by Dao-Cheng Zhou (20314697)

“…However, the association of LE8 with all-cause and disease-specific mortality in the MetS population remains unknown. We aimed to explore these associations in a national prospective cohort study from NHANES 2005–2018.…”

Descriptive statistics for pulse pressure , the pulsatility index , and the damping factors obtained from these two indexes ( and ) in the pial vascular networks for the different... by Eduardo G. Zilves (22209247)

β-Catenin signalling cells increase with Wnt3a but have reduced SSC activity. by Jonathan R. Yeh (155141)

“…Asterisks indicate significance from fraction II. Scale bar: (A–B) 50 µm, inset: 100 µm.</p>…”

Human mesenchymal stem/stromal cells (hMSCs) increased <i>Ccl2</i> expression and reduced inflammatory responses. by Kazumichi Yagura (4537504)

“…Animals treated with hMSCs (n = 10 mouse) exhibited significant decreases in <i>Il1b</i> <b>(H)</b>, <i>Elane</i> <b>(I)</b>, and <i>Mpo</i> <b>(J)</b> expression in the spinal cord on pod 3 relative to HBSS-treated animals (n = 5 mouse). …”

S1 Data - by Elizabeth Dufourcq Sekatcheff (17457627)

“…Thus, sperm decrease seems to be mediated via another mechanism, probably a decrease in germ cell proliferation speed that needs further investigation to better characterize sex-specific responses to IR exposure. …”

The Δ<i>fruR</i> strain has decreased plaque size and numbers in L2 fibroblast monolayers compared to wildtype and complemented Δ<i>fruR</i> (Δ<i>fruR_</i>com). by Hossam Abdelhamed (419443)

Human disease-causing mutations in <i>LMOD2</i> result in a decrease in mature, but not pre-, mRNA levels when expressed from a construct containing a downstream intron, which is a... by Christopher T. Pappas (8218833)