Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer by Xingchen Liu (524190)

“…In this study, we designed a series of parthenolide (PTL) derivatives through a stepwise structure optimization, and an excellent derivate <b>29e</b> showed good activity on PKM2 (AC₅₀ = 86.29 nM) and displayed significant antiproliferative activity against HT29 (IC₅₀ = 0.66 μM) and SW480 (IC₅₀ = 0.22 μM) cells. …”

Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer by Xingchen Liu (524190)

“…In this study, we designed a series of parthenolide (PTL) derivatives through a stepwise structure optimization, and an excellent derivate <b>29e</b> showed good activity on PKM2 (AC₅₀ = 86.29 nM) and displayed significant antiproliferative activity against HT29 (IC₅₀ = 0.66 μM) and SW480 (IC₅₀ = 0.22 μM) cells. …”

Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer by Xingchen Liu (524190)

“…In this study, we designed a series of parthenolide (PTL) derivatives through a stepwise structure optimization, and an excellent derivate <b>29e</b> showed good activity on PKM2 (AC₅₀ = 86.29 nM) and displayed significant antiproliferative activity against HT29 (IC₅₀ = 0.66 μM) and SW480 (IC₅₀ = 0.22 μM) cells. …”

Effect of C282Y-HFE on the expression of genes involved in lipoprotein signaling and cholesterol metabolism in human neuroblastoma SH-SY5Y cell lines. by Fatima Ali-Rahmani (522282)

Single allele dysfunction of <i>ERG251</i> in combination with concurrent aneuploidy causes azole resistance. by Xin Zhou (54275)

Details of mapped caffeine resistance QTL. by Michael A. Najarro (831657)

Disruption of the viral cyclin results in a reduced frequency of LANA::βla expressing cells in the peritoneum of CD8-/- mice. by Brian F. Niemeyer (11707995)

An Allosteric Modulator of RNA Binding Targeting the N‑Terminal Domain of TDP-43 Yields Neuroprotective Properties by Niloufar Mollasalehi (9511076)

“…<i>In silico</i> docking of 50K compounds to the NTD domain of TDP-43 identified a small molecule (nTRD22) that is bound to the N-terminal domain. …”

The number of amyloid plaques and amount of Aβ_1-42 were reduced in S100A9 KO/Tg mice. by Hee Jin Kim (469168)

“…Sections are 4 µm thick. ((a) – (h) Scale bar; 200 µm, (i)-(l) scale bar; 50 µm). …”

MDS erythroid precursors are deficient in membrane lipid rafts. by Kathy L. McGraw (327439)

“…Enlarged images illustrate lipid rafts at 630x with 6-zoom magnification. Bars represent 5 µm. (B) Statistically significant decrease in the number of rafts per cell in MDS erythroid precursors compared to normal donor erythroid cells, graph represents mean ± SE. …”

Characterization of journals being listed in the DOAJ and their development over time (2011–2018). by Georg Richtig (4582933)

Antimicrobial activity of RP-1 peptide conjugate with ferrocene group by Natalia C. S. Costa (8626206)

“…In comparison with amphotericin B, a second-line drug approved for leishmaniasis treatment, (IC₅₀ = 0.63 μmol L^-1), Fc-RP1 was more active and showed a 2.5-fold higher selectivity index. …”

Characterization of journals being listed on Beall’s list and their development over time (2011–2018). by Georg Richtig (4582933)

ING1 is one of the miR-371-5p targets and negatively regulated by miR-371-5p. by De He (497662)

Effect of DM, and/or <i>M. charantia</i> on the immuno-expressional level of NGF protein in maternal cerebellar tissue of different groups. by Amoura M. Abou-El-Naga (21001524)

“…The values are expressed as the means±SEM of 5 microscopic fields/tissue samples of NGF immune-expression, **<i>P</i> < 0.01.…”

Discovery, Synthesis, and Activity Evaluation of Novel Five-Membered Sulfur-Containing Heterocyclic Nucleosides as Potential Anticancer Agents In Vitro and In Vivo by Er-Jun Hao (10097665)

“…Among them, compound <b>22o</b> exhibited remarkable antiproliferative activity against HeLa cells and was more potent than cisplatin (IC₅₀ = 2.80 vs 7.99 μM). Furthermore, mechanism studies indicated that <b>22o</b> inhibited cell metastasis, induced cell apoptosis, decreased mitochondrial membrane potential, and activated autophagy through the PI3K-Akt-mTOR signaling pathway. …”

Discovery, Synthesis, and Activity Evaluation of Novel Five-Membered Sulfur-Containing Heterocyclic Nucleosides as Potential Anticancer Agents In Vitro and In Vivo by Er-Jun Hao (10097665)

“…Among them, compound <b>22o</b> exhibited remarkable antiproliferative activity against HeLa cells and was more potent than cisplatin (IC₅₀ = 2.80 vs 7.99 μM). Furthermore, mechanism studies indicated that <b>22o</b> inhibited cell metastasis, induced cell apoptosis, decreased mitochondrial membrane potential, and activated autophagy through the PI3K-Akt-mTOR signaling pathway. …”

Correlation between total memory or naïve Tregs with PD1⁺ CD95⁺ cells. by Vedran Brezar (337452)

Cell-targeted transgenic control of 5HT_2AR levels in neurons and glia during the experience-dependent critical period. by Vanessa Kay Miller (19775496)

“…Two-way ANOVA with Tukey’s multiple comparison shows EB experience-dependent increase in 5HT_2A receptor levels in both transgenic controls (<i>n</i> = 10 each, <i>repo-</i>Gal4<i>; p</i> = 5.38 × 10⁻¹⁰, <i>elav</i>-Gal4; <i>p</i> = 0.0205), a significant decrease in 5HT_2A receptor levels in both RNAi conditions (<i>n</i> = 10 each, <i>repo-</i>Gal4<i>; p</i> = 4.63 × 10⁻¹⁰, <i>elav-</i>Gal4; <i>p</i> = 1.05 × 10⁻⁹), and a significant elevated EB response with glial <i>5HT</i>_<i>2A</i><i>R</i> OE (<i>n</i> = 10/condition, <i>p</i> = 2.36 × 10⁻⁹). …”

Enhanced Rice Blast Resistance by CRISPR/Cas9-Targeted Mutagenesis of the ERF Transcription Factor Gene <i>OsERF922</i> by Fujun Wang (96184)

“…Here, we report the improvement of rice blast resistance by engineering a CRISPR/Cas9 SSN (C-ERF922) targeting the <i>OsERF922</i> gene in rice. …”