Image_1_Defective Autophagy in T Cells Impairs the Development of Diet-Induced Hepatic Steatosis and Atherosclerosis.TIF by Jacob Amersfoort (6075341)

“…Atg7 deficiency furthermore reduced the hepatic NKT cell population which was decreased to < 0.1% of the lymphocyte population. Interestingly, T cell-specific knock-out of Atg7 decreased the mean atherosclerotic lesion size in the tri-valve area by over 50%. …”

Image_3_Defective Autophagy in T Cells Impairs the Development of Diet-Induced Hepatic Steatosis and Atherosclerosis.TIF by Jacob Amersfoort (6075341)

“…Atg7 deficiency furthermore reduced the hepatic NKT cell population which was decreased to < 0.1% of the lymphocyte population. Interestingly, T cell-specific knock-out of Atg7 decreased the mean atherosclerotic lesion size in the tri-valve area by over 50%. …”

Image_2_Defective Autophagy in T Cells Impairs the Development of Diet-Induced Hepatic Steatosis and Atherosclerosis.TIF by Jacob Amersfoort (6075341)

“…Atg7 deficiency furthermore reduced the hepatic NKT cell population which was decreased to < 0.1% of the lymphocyte population. Interestingly, T cell-specific knock-out of Atg7 decreased the mean atherosclerotic lesion size in the tri-valve area by over 50%. …”

Table_1_Defective Autophagy in T Cells Impairs the Development of Diet-Induced Hepatic Steatosis and Atherosclerosis.DOCX by Jacob Amersfoort (6075341)

“…Atg7 deficiency furthermore reduced the hepatic NKT cell population which was decreased to < 0.1% of the lymphocyte population. Interestingly, T cell-specific knock-out of Atg7 decreased the mean atherosclerotic lesion size in the tri-valve area by over 50%. …”

p21 is regulated by AR and required for cellular senescence. by Yelena Mirochnik (179447)

“…Tubulin was used as a loading control (A). Note the decrease in Rb phosphorylation and p21 increase in DHT-treated cells at every time point. …”

Effect of rPVH1-yCD/5FC treatment on NFκB and Akt/PI3K activity. by Soukaina Réjiba (445416)

“…The specificity of the band corresponding to NFκB-DNA complex was determined using non-labeled NFκB consensus oligonucleotide as a specific competitor. <b>C</b>) wtPV-H1 and rPVH1-yCD/5-FC decrease Akt/PI3K constitutive activity. …”

Supplementary Material for: Systematic Review and Meta-Analysis of the Impact of Hypoxia on Infarcted Myocardium: Better or Worse? by Pang B. (5404793)

“…Overall, chronic hypoxia was found to have a beneficial effect on the ejection fraction (standard mean difference [SMD] = 5.39; 95% confidence interval [CI], 3.83 to 6.95; <i>P</i> < 0.001) of the infarcted heart, whereas acute hypoxia significantly improved hemodynamics, as indicated by an increase in the maximal rate of rise of left ventricular pressure (SMD = 1.27; 95% CI, 0.27 to 2.28; <i>P</i> = 0.013) and cardiac output (SMD = 1.26; 95% CI, 0.34 to 2.18; <i>P</i> = 0.007) and a decrease in total systematic vascular resistance (SMD = –0.89; 95% CI, –1.24 to –0.53; <i>P</i> < 0.001). …”

Changes in phosphorylation of proteins associated with co-translation and ER-Golgi vesicle traffic. by Yashoda Kandel (6392810)

“…Green arrows represent an increase of at least 1.5-fold in phosphorylation at the specified residue between unfed and PBM mosquitoes, and red arrows represent a decrease of at least 1.5-fold in phosphorylation at the specified residue between unfed and PBM mosquitoes.…”

Monocyte gene expression in HIV/HCV coinfection compared to HCV and HIV monoinfection. by Hans Rempel (44689)

“…Differentially expressed genes (DE; compared to healthy controls) were transformed and displayed as log fold change. Monocyte DE genes in the HIV-suppressed coinfected subjects (induced ≥2-fold and sorted in decreasing fold change) were matched with corresponding genes in monoinfected subjects. …”

Knockdown of PTEN in breast cancer cell lines results in enrichment of breast cancer stem/progenitor cells via the Akt/GSK3-β/β-catenin pathway. by Hasan Korkaya (159560)

“…Perifosine treatment decreased the proportion of GFP-positive cells by more than 50%, whereas Bio treatment increased the proportion of GFP-positive cells more than 2-fold and reversed the inhibitory effect of perifosine. …”

Relative changes in glycolysis and the PPP observed in metabolomic analyses. by Julie Kovářová (4114573)

“…Numbers are relative values in Δtkt compared to WT, red numbers and arrows indicate the fold increase, whereas blue indicates the fold decrease. …”

Identification of rice embryo mitochondrial proteins from 0 d, 3 d, and 4 d aged seeds using MS/MS peptide spectra matched to iPSORT and NCBI entries. by Guangkun Yin (2635402)

“…<p>Compared to the control, fold changes were represented by a cut off following a 2-fold increase (Up-regulated) or decrease (Down-regulated).…”

Analysis of the relative expression of the PTEN pathway genes. by Edurne Novella-Maestre (746958)

“…G2 p = 0.01) and in previously cryopreserved ovarian tissues (G4 <i>vs</i>. G5 p = 0.04); (B) fold change of the <i>FOXO3</i> gene. A significant decrease was detected only in the fresh tissues that underwent IVA treatment when ∆Ct were analyzed (G1 <i>vs</i>. …”

Differential expression of cell cycle proteins on treatment with hUCBSC. by Kiran Kumar Velpula (183866)

“…Real time PCR was carried out and changes in gene expression were illustrated as fold increase/decrease according to manufacturer’s instructions. …”

Differentiation outcomes and gene expression from EPL cells cultured in an FGF signalling inhibitor. by Zhiqiang Zheng (91599)

“…(<b>B</b>) Differentiation outcomes from EPL cells cultured in serum-containing medium supplemented with 50 and 75 nM PD173074. Addition of PD173074 resulted in a significant decrease in cardiomyocytes and blood and a significant increase in neuron formation. n = 3. * indicates a significant increase (p<0.05) when compared to serum + DMSO. # indicates a significant decrease (p<0.05) when compared to serum + DMSO. …”

FIGURE 6 from Targeting <i>MALAT1</i> Augments Sensitivity to PARP Inhibition by Impairing Homologous Recombination in Prostate Cancer by Anjali Yadav (17117308)

“…The IC₅₀ values were calculated by generating a dose–response curve using GraphPad Prism software. …”

Key for figures and hypothesis tables. by Renée Deehan (326438)

“…<p>Green and red boxes = observed increases and decreases, respectively, in RNA expression of a given gene. …”

Characterization of hADRB1 and hADRB2 after trace amine challenge. by Gunnar Kleinau (103422)

“…TYR shows no agonistic effect on hADRB1 (p<0.05) and hADRB2 (p<0.01), but acts as an allosteric antagonist on hADRB1/2, indicated by a decreased maximum of stimulation (p<0.05) with comparable EC₅₀ values. …”

Exercise reduces <i>C1qa</i>⁺ microglia/monocytes in the aged cortex. by Ileana Soto (531878)

“…(B) Quantification of IBA1⁺ cells in aging, aged sedentary (Sd), and aged runner (Rn) mice shows a decrease in microglia/monocyte density in the aged runners versus the aged sedentary mice. …”

[Ca²⁺]_i oscillations during stimulation with 12 mM glucose. by Jurij Dolenšek (276793)

“…Y axis represents the normalized fraction of the difference between maximum and plateau baseline fluorescence. <b>D</b> A pseudo-colored representation of time lags between oscillation end₅₀ in the cell in which [Ca²⁺]_i decreased first and every other cell. …”