Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents by Gianluca Santoni (1991434)

“…The chlorinated derivative was synthesized and, in line with the prediction, displayed a 10-fold decrease in inhibition but no significant decrease in reactivation efficiency. …”

Phenotypes associated with lifespan extension and stress resistance are observed in <i>hyl-1;lagr-1</i>. by Mai-Britt Mosbech (435186)

“…Bars represent the mean number of pumps per minute. Compared to N2 displaying a mean pumping rate of 201±2 pumps/min, <i>hyl-1;lagr-1</i> shows a 17.4% decrease with a mean pumping rate of 166±2, P<0.0001, while <i>eat-2</i> shows a 67.2% decrease with a mean pumping rate of 66±3, P<0.0001. …”

Heat map of the profiles of metabolites involved in photorespiration. by Fatma Kaplan (140972)

“…<p>All changes in metabolite levels had a statistically significant response (p-value ≤0.001) and more than 2 fold increase or decrease at any one treatment.…”

Variable importance plot for Eurasian beaver behaviours. by Patricia M. Graf (789356)

“…<p>A relative ranking of significant predictors, the permutation-based variable importance measure of the random forest model, is shown as the mean decrease in accuracy in percent. …”

Expression of microRNA-548ac <i>in vitro</i> and effect of SNP rs1414273. by Michael Hecker (51971)

“…(<b>C</b>) Relative expression of hsa-mir-548ac precursor transcripts after transient transfection. A more than 10-fold decrease in the precursor levels was consistently observed from the 24 h to the 48 h time point. …”

Nef Targets ABCA1-Dependent Cholesterol Efflux by Zahedi Mujawar (379543)

“…<div><p>(A) Cholesterol efflux to HDL (30 μg/ml) was measured from HIV-1 ADA-infected and mock-infected macrophages used also to measure efflux to apoA-I in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0040365#pbio-0040365-g001" target="_blank">Figure 1</a>A.…”

Changes in phosphorylation of cell-cell adhesion proteins. by Yashoda Kandel (6392810)

“…Green arrows represent an increase of at least 1.5-fold in phosphorylation at the specified residue between unfed and PBM mosquitoes, and red arrows represent a decrease of at least 1.5-fold in phosphorylation at the specified residue between unfed and PBM mosquitoes.…”

Anti-correlation functional profiling identifies relevant miRNA-target interactions, including miR-150 repression of p53, that regulate MV4-11 cell line growth. by Jared Wallace (410659)

“…<p>(A) Heat map indicating representative oncogenes whose loss leads to decreased cell growth according to Log2 Fold Change values from lentiCRISPRv2 library screen (first column), and functionally anti-correlated miRNAs that are predicted to target each oncogene. …”

Immunofluorescence staining of HS and Syndecan-1. by Scott Cooper (3373172)

“…<p>Following 24hr of flow conditioning (inlet WSS of 10 dyne/cm²), mean fluorescence intensity (n = 3, mean intensity ± SEM) of (A) of HS which showed a significant decrease in mean intensity in the Dean’s flow region relative to the inlet (Bonferroni post-hoc test, P<0.05) and (B) Syndecan-1 which also showed a significant decrease in mean intensity in the Dean’s flow region relative to the inlet (Bonferroni post-hoc test, P<0.05). …”

The effects of forskolin on TNF-α secretion by LPS-treated RT4-D6P2T cells. by Caitlyn Henry (18388577)

“…The Invitrogen Rat TNF alpha ELISA kit (RayBiotech) was used to quantify the TNF-α concentration (pg/mL) in media samples, which is displayed as mean fold change ± SEM. The dotted line indicates a fold change of 1, with a fold change above 1 representing increased TNF-α secretion and a fold change below 1 representing decreased TNF-α secretion compared to the N₂ control. …”

Protective effects of 20E against H₂O₂-induced cytotoxicity in B35 cells. by Jun Hu (5721)

“…Cells were pretreated with 20E (50 or 400 µM) for 24 h before a 12 h incubation with H₂O₂, and then LDH release (% of total) was calculated as the percentage of LDH in the medium versus total LDH activity in the cells. …”

Volcano plot of cell type specific genes. by Nelson T. Gross (9028031)

“…The two vertical lines indicate a threshold of log₂ fold of difference of -1 (left) or +1 (right). …”

Changes in titers to four recent strains. by Bingyi Yang (633876)

“…We divided the changes in titers into four categories, i.e. decrease (green), no change (grey), two-fold increase (light purple) and four-fold change (seroconversion, dark purple).…”

Percent reduction in the relative transcript levels due to target gene silencing in the females of <i>M</i>. <i>incogntia</i> feeding on the transgenic plants. by Pradeep Kumar Papolu (480570)

“…<p>(A) Decrease in mRNA abundance in <i>M. incogntia</i> females extracted from (A) <i>flp-14</i> (B) <i>flp-18</i> transgenic tobacco lines. …”

Concentrations of Mn from different species in brain extracts according to SEC-ICP-MS. by Katharina Neth (797376)

“…<p>(A) The figure shows by columns the respective Mn concentrations of SEC fractions A-F (MW in kDa) for control and +Mn samples as well at the fold-change in increase (n = 15 per group). …”

Fluorescence quenching in isolated CAC antennae. by Radek Kaňa (190860)

“…<b>B</b>) Protein samples were diluted 10-fold to decrease concentration of dodecyl-β-maltoside – sample addition to buffer (20 mM HEPES, pH 8.0) is visible as chlorophyll fluorescence appearance (arrow ‘Sample’) that slowly decrease. …”

Representative results of integrate-and-fire simulations for different learning rules. by Kendra S. Burbank (180062)

“…The simulations in <b>b–d</b> were classified as having “extreme weights” meaning that >50% of the weights were either at 0 or at the weight boundaries (±50). …”

Data_Sheet_1_Insulin Modulates the Immune Cell Phenotype in Pulmonary Allergic Inflammation and Increases Pulmonary Resistance in Diabetic Mice.pdf by Sabrina S. Ferreira (8432574)

“…</p><p>Materials and Methods: To evaluate the effects of relative insulin deficiency, an experimental model of diabetes was induced by a single dose of alloxan (50 mg/kg, i.v.). After 10 days, the mice were sensitized with ovalbumin [OVA, 20 μg and 2 mg of Al(OH)₃, i.p.]. …”

PITX2 promotes ovarian cancer cell growth. by Frederic K. C. Fung (164563)

“…(<b>D</b>) Depletion of endogenous PITX2 reduced cell proliferation in ovarian cancer cells. A 3- to 4- fold of reduction on cell viability in both knockdown clones (K1 and K2) of OV2008 cells (** <i>P</i><0.01) and 2- to 3- fold decrease on cell proliferation in knockdown clones (K1 and K2) of OVCA 433 cells (* <i>P</i><0.05) were observed.…”

<i>S</i>. <i>pneumoniae</i> RNA regulators are ligand responsive and most designed mutations function as anticipated. by Indu Warrier (581139)

“…Bar height indicates the mean replicate value, error bars indicate standard error of the mean, individual points shown in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011188#pgen.1011188.s009" target="_blank">S2 Fig</a>. …”