Synthesis and bioactivity of the γ-secretase modulator photo-probe AR243. by Thorsten Jumpertz (188948)

“…AR243 caused a dose-dependent decrease in Aβ42 levels with a concomitant increase in Aβ38 levels, confirming its bioactivity as a potent GSM with an IC₅₀ for Aβ42 reduction of 290 nM.…”

<i>foxP2</i> does not affect neuron specification, apoptosis, or proliferation, but does affect <i>cntnap2</i> expression levels. by Lingyan Xing (310457)

“…<p>Confocal z-stack images, rostral to the top, scale bars 50 μm. (A, B, E-H, K-L) ventral views. (C, D) dorsal views. …”

LANA31-GFP-IBD reverses effect of combined LEDGF/p75 depletion and GFP-IBD dominant interference. by Anne M. Meehan (261905)

“…(C) HIV-1 reporter virus challenge. TL4 cells demonstrate a 456-fold decrease in HIV-1 infectivity. LANA31-GFP-IBD effects a 200-fold rescue, functioning comparably to re-expressed LEDGF/p75 and in contrast to the LANA31-GFP-IBD^D366N. …”

Reduction of CSF leucocyte count and induction of apoptosis by roscovitine <i>in vivo.</i> by Uwe Koedel (263360)

“…<p>Wild type mice were subjected to pneumococcal meningitis by bacterial injection into the cisterna magna and treated either with a combination of ceftriaxone (100 mg/kg, intraperitoneally) and roscovitine (50 mg/kg intraperitoneally) or ceftriaxone and the vehicle of roscovitine (PBS+20% DMSO). …”

Data Sheet 2_Bevacizumab and anlotinib combination therapy acts via HIF-1α suppression to exert synergistic anti-angiogenic and anti-tumor effects in non-small cell lung cancer.pdf... by Nafeisha Simayi (22262161)

“…The phosphorylation of VEGFR2, PDGFRβ, and FGFR1 was also reduced. B+A reduced tumor volume 7.23-fold and weight 7.08-fold, decreased tumor cell density, and lowered Ki-67 expression in an in vivo mouse xenograft model. …”

Data Sheet 1_Bevacizumab and anlotinib combination therapy acts via HIF-1α suppression to exert synergistic anti-angiogenic and anti-tumor effects in non-small cell lung cancer.zip... by Nafeisha Simayi (22262161)

“…The phosphorylation of VEGFR2, PDGFRβ, and FGFR1 was also reduced. B+A reduced tumor volume 7.23-fold and weight 7.08-fold, decreased tumor cell density, and lowered Ki-67 expression in an in vivo mouse xenograft model. …”

Population statistics of latency tuning. by Oren Shriki (157992)

“…(C) A scatter plot of <i>A</i> vs. <i>B</i> for first spike latency (each point represents one unit; correlation coefficient 0.85). …”

Analysis of Oxygen/Glucose-Deprivation-Induced Changes in SUMO3 Conjugation Using SILAC-Based Quantitative Proteomics by Wei Yang (109917)

“…Collectively, these results suggest several mechanisms for OGD-modulated SUMOylation, point to a number of signaling pathways that may be targets of SUMO-based signaling and recovery from ischemic stress, and demonstrate a tightly controlled crosstalk between the SUMO and ubiquitin conjugation pathways.…”

Rheological behavior of concentrated tucupi by Telma dos Santos COSTA (4618960)

“…Rheology at 25 °C indicated that the partial gelification of starch during concentration causes a decrease in the product’s viscosity and, if the concentration is carried out at a temperature that favors total starch gelification, the product’s viscosity increases. …”

Rheological behavior of concentrated tucupi by Telma dos Santos COSTA (4618960)

“…Rheology at 25 °C indicated that the partial gelification of starch during concentration causes a decrease in the product’s viscosity and, if the concentration is carried out at a temperature that favors total starch gelification, the product’s viscosity increases. …”

Enhanced electropermeabilization of peroxidized cells with both ultra-short and conventional electric pulse treatments. by P. Thomas Vernier (142483)

“…Peroxidized cells treated with a single 100 µs, 50 kV/m pulse show a similar increased susceptibility to electropermeabilization. …”

Transcriptomics identifies keratin filaments working downstream of mitochondrial Ca²⁺ dynamics to regulate melanogenesis. by Jyoti Tanwar (2230597)

“…<p><b>(A)</b> Representative pellet images of B16 LD cells used for RNA sequencing. …”

TRIM5α induces an antiviral state following infection with restricted viruses. by Natacha Merindol (3521828)

“…The total percentage of GFP⁺ cells is shown in bold. <b>(b)</b> Fold decreases in NRC1_GFP (n = 25) and NRC10_GFP (n = 17) infectivity in T5KO and control (CAG) Jurkat cells subjected to a first infection with isolates-derived DsRed-vectors. …”

Genome-wide differentially methylated genes in prostate cancer tissues from African-American and Caucasian men by JM Devaney (722915)

“…Knockdown of either ABCG5 or SNRPN resulted in a significant decrease in both invasion and proliferation in Cau PCa cell lines but we did not observe these remarkable loss-of-function effects in AA PCa cell lines. …”

Characteristics of significantly associated miRs. by Stefan Wuchty (195634)

“…<p>(<b>A</b>) A sigmoidal curve described the fold change of all mRNAs that appeared in signaling pathways and were not bound by significantly associated miRs. …”

Simulated temporal dynamics in E2F activation using the stochastic Rb-E2F model. by Tae J. Lee (241477)

“…<p>(A) Stochastic simulations (25 events) exhibit variable time delays in E2F activation, as shown in gray lines. …”

DataSheet1_Non-target screening to track contaminant removal and release during nature-based water treatment.docx by Charlotte Guy (18392850)

“…Natural products predominantly increased after RB contact, while compounds exhibited a significant 75% decrease in peak area are mainly pharmaceuticals. …”

Table7_Non-target screening to track contaminant removal and release during nature-based water treatment.xlsx by Charlotte Guy (18392850)

“…Natural products predominantly increased after RB contact, while compounds exhibited a significant 75% decrease in peak area are mainly pharmaceuticals. …”

Table6_Non-target screening to track contaminant removal and release during nature-based water treatment.xlsx by Charlotte Guy (18392850)

“…Natural products predominantly increased after RB contact, while compounds exhibited a significant 75% decrease in peak area are mainly pharmaceuticals. …”

Transfection of catalytically active BPLF1 inhibits activation of the DDR and DNA repair in etoposide treated HeLa cells. by Jinlin Li (2267896)

“…Mean ± SE of two or three independent experiments where a minimum of 50 BPLF1 positive and 50 BPLF1 negative cells was scored in each condition.…”