Image_2_Dynamics of Type I and Type II Interferon Signature Determines Responsiveness to Anti-TNF Therapy in Rheumatoid Arthritis.jpeg by Takeshi Iwasaki (3279906)

“…The expression of type II IFN signaling-related genes did not significantly differ before treatment; however, it increased in non-responders and decreased in responders, with a significant difference being observed after three months of treatment (P = 1.2×10^-3). …”

Image_5_Dynamics of Type I and Type II Interferon Signature Determines Responsiveness to Anti-TNF Therapy in Rheumatoid Arthritis.jpeg by Takeshi Iwasaki (3279906)

“…The expression of type II IFN signaling-related genes did not significantly differ before treatment; however, it increased in non-responders and decreased in responders, with a significant difference being observed after three months of treatment (P = 1.2×10^-3). …”

Data_Sheet_1_Utilizing Andrographis paniculata leaves and roots by effective usage of the bioactive andrographolide and its nanodelivery: investigation of antikindling and antioxid... by Ramana Baru Venkata (15998264)

“…In this study, we used GSE28674 as a microarray expression profiling dataset to identify DEGs associated with andrographolide and those with fold changes >1 and p-value <0.05 GEO2R. …”

The conserved bioenergetic role of CAPER is essential for organismic survival and reproductive capacity in <i>C</i>. <i>elegans</i>. by Yun Kyoung Kang (715990)

“…<i>3</i> disturbs carbon and nitrogen balance in whole worms. A heat map showing altered metabolites by Log ₂ (FC: fold change) (left two colums-24 hour and 48 hour samples) and by Log ₁₀(p values) (p values adjusted for multiple comparisons using Benjamini-Hochberg method) (right two columns). …”

Image_3_Dynamics of Type I and Type II Interferon Signature Determines Responsiveness to Anti-TNF Therapy in Rheumatoid Arthritis.jpeg by Takeshi Iwasaki (3279906)

“…The expression of type II IFN signaling-related genes did not significantly differ before treatment; however, it increased in non-responders and decreased in responders, with a significant difference being observed after three months of treatment (P = 1.2×10^-3). …”

Image_4_Dynamics of Type I and Type II Interferon Signature Determines Responsiveness to Anti-TNF Therapy in Rheumatoid Arthritis.jpeg by Takeshi Iwasaki (3279906)

“…The expression of type II IFN signaling-related genes did not significantly differ before treatment; however, it increased in non-responders and decreased in responders, with a significant difference being observed after three months of treatment (P = 1.2×10^-3). …”

DataSheet_2_Dynamics of Type I and Type II Interferon Signature Determines Responsiveness to Anti-TNF Therapy in Rheumatoid Arthritis.docx by Takeshi Iwasaki (3279906)

“…The expression of type II IFN signaling-related genes did not significantly differ before treatment; however, it increased in non-responders and decreased in responders, with a significant difference being observed after three months of treatment (P = 1.2×10^-3). …”

The pattern of age declines and improvements across the adult lifespan. by Bob Uttl (53434)

“…<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0001568#pone.0001568-Salthouse1" target="_blank">[50]</a>; in blue: U'01 = Uttl et al. …”

PAI-1 inhibition leads to the accumulation of VE-cadherin at the Golgi apparatus. by Anna E. Daniel (841267)

“…<p>(A) HUVEC were treated with PAI-039 (25 μM) or solvent (DMSO 0.1%) for four hours and stained for VE-cadherin (green) and GM130 (red) (scale bar 50 μm). …”

Effect of azurin in FAK-Src signaling. by Nuno Bernardes (435240)

“…<p>Azurin at 50 µM and 100 µM decreased phosphorylation levels of FAK Y397 and Src Y416 in both MCF-7/AZ.Pcad and SUM149 breast cancer cells, but not Akt S473, in a dose-dependent manner. …”

Optimization of 4,6-Disubstituted Pyrido[3,2‑<i>d</i>]pyrimidines as Dual MNK/PIM Inhibitors to Inhibit Leukemia Cell Growth by Yu Han (251741)

“…<b>21o</b> inhibits the growth of myeloid leukemia K562 and MOLM-13 cells with GI₅₀’s of 2.1 and 1.2 μM, respectively. <b>21o</b> decreases the levels of <i>p</i>-eIF4E and <i>p</i>-4EBP1, the downstream products of MNKs and PIMs, as well as cap-dependent proteins c-myc, cyclin D1, and Mcl-1. …”

DataSheet3_Polydatin attenuates tubulointerstitial fibrosis in diabetic kidney disease by inhibiting YAP expression and nuclear translocation.ZIP by Manlin He (13921176)

“…Our results prove for the first time from the biomechanical point of view that PD is a potential therapeutic strategy for delaying the progression of renal fibrosis by inhibiting YAP expression and nuclear translocation.…”

DataSheet3_Gallic Acid Alleviates Neuropathic Pain Behaviors in Rats by Inhibiting P2X7 Receptor-Mediated NF-κB/STAT3 Signaling Pathway.docx by Runan Yang (6579239)

“…<p>Neuropathic pain is a complex disease with high incidence. Adenosine triphosphate (ATP) and its activated P2X7 receptor are involved in the signal transmission of neuropathic pain. …”

Data Sheet 1_Altered immune cell profiles in blood of mature/peripheral T-cell leukemia/lymphoma patients: an EuroFlow study.docx by F. Javier Morán-Plata (18986483)

“…Further dissection of the normal T-cell compartment showed a significant reduction of the earliest T-cell maturation compartments (N/CM) in T-PLL and SS/MF, whereas T-cells remained within normal ranges in T-LGLL, with only a minor reduction of N/CM T-cells.…”

Data_Sheet_8_TREM2 improves neurological dysfunction and attenuates neuroinflammation, TLR signaling and neuronal apoptosis in the acute phase of intracerebral hemorrhage.ZIP by Sidan Liu (4353826)

“…ICH increased the percentage of TUNEL-positive cells, which was markedly decreased by TREM2 overexpression. A similar improvement was also observed by the administration of TAK242 following ICH. …”

DataSheet_2_Identifying Biomarkers from Transcriptomic Signatures in Renal Allograft Biopsies Using Deceased and Living Donors.docx by Bin Yang (103252)

“…These genes were further validated by quantitative polymerase chain reaction (qPCR) in 24 samples analysed by microarray, as well as in a validation cohort of 33 time point unpaired allograft biopsies. …”

Table_1_TREM2 improves neurological dysfunction and attenuates neuroinflammation, TLR signaling and neuronal apoptosis in the acute phase of intracerebral hemorrhage.XLSX by Sidan Liu (4353826)

“…ICH increased the percentage of TUNEL-positive cells, which was markedly decreased by TREM2 overexpression. A similar improvement was also observed by the administration of TAK242 following ICH. …”

Forced Trefoil Factor Family Peptide 3 (TFF3) Expression Reduces Growth, Viability, and Tumorigenicity of Human Retinoblastoma Cell Lines by Jan Große-Kreul (3119874)

“…Our study demonstrates that forced <i>TFF3</i> expression exerts a significant pro-apoptotic, anti-proliferative, and tumor suppressive effect in retinoblastoma cells, setting a starting point for new additive chemotherapeutic approaches in the treatment of retinoblastoma.…”

Data_Sheet_1_Non-specific markers of inflammation in bare-nosed wombats (Vombatus ursinus) with sarcoptic mange.pdf by Vicky Wilkinson (13173793)

“…Meanwhile, owing to its relatively low resource requirements and rapidity, the erythrocyte sedimentation rate assay may be useful as a point-of-care test to support therapeutic decisions in the field. …”

DataSheet_1_Identifying Biomarkers from Transcriptomic Signatures in Renal Allograft Biopsies Using Deceased and Living Donors.docx by Bin Yang (103252)

“…These genes were further validated by quantitative polymerase chain reaction (qPCR) in 24 samples analysed by microarray, as well as in a validation cohort of 33 time point unpaired allograft biopsies. …”