TBC-2 is required for full lifespan extension and increased fat storage resulting from decreased insulin/IGF signaling. by İçten Meraş (13184380)

Perturbing the ORF57-REF/Aly interaction with point mutations decreases cytoplasmic accumulation of viral mRNA. by Richard B. Tunnicliffe (233562)

“…Point mutations of ORF57 residues implicated in direct interaction with REF, and reducing its binding, all caused significant decrease in cytoplasmic accumulation of viral mRNA.…”

Adaptation to cool temperature decreases basal and stimulated lipolysis and increases <i>de novo</i> lipogenesis and TAG synthesis. by Hiroyuki Mori (512656)

“…<p>(<b>A, B</b>) Adipocytes were treated with 10 μM forskolin or 2 μM CL-316,243 (CL) for 6 hours and secretion of glycerol (<b>A</b>) and NEFA (<b>B</b>) measured (<i>n</i> = 4). …”

The RsW50 of regulatory spleen cells is decreased by enriching for CD8⁺ regulatory spleen cells. by Roshanak Sharafieh (311047)

Decreased expression of SOCS1 protein and mRNA in SLE and its relation to Jak1 and STAT2 phosphorylation. by Gabriela Ramírez-Vélez (146925)

Inhibition of GLS1 decreases the proportion of CCR6 and CXCR3 expressing CD4⁺ T cells. by Zeynep Sener (3146064)

“…(B–C) The proportion of CCR6 expressing cells at day 3 (left) and day 5 (right) under normoxia (black bars) and hypoxia (grey bars) in the presence (+) and absence (-) of 25 μM BPTES and 50 μM 968. BPTES and 968 significantly decrease the proportion of CCR6 expressing cells under normoxia both at day 3 and 5, whereas 968 but not BPTES decrease the proportion of CCR6 expressing cells under hypoxia both at day 3 and 5. …”

THRα/β EC₅₀ values and selectivity of test compounds. by Xuan G. Luong (9761423)

Panobinostat downregulated Ron mRNA, protein expression and decreased downstream signaling through pAkt, XIAP, and survivin. by Yi Zou (439002)

Geniposide(Gen) significantly decreased the levels of TNF-α and MIP-1α in BALF of bleomycin-induced PF mice. by Jian-Bin Yin (19556105)

PDK1 inhibitor PF-5177624 decreased IGF-I induced AKT and p70S6K phosphorylation. by Sangita M. Baxi (123560)

Downregulation of G9a induces autophagy and decreases tumorigenicity in neuroblastoma cells. by Xiao-Xue Ke (626989)

SARS-CoV-2 induced lung inflammation is increased with IL-10 blockade and decreased with IFNγ blockade. by Christine E. Nelson (18946410)

IRE1 depletion decreases heterochromatin, DNA and H3K9me3 methylation, and UHRF1. by Iratxe Zuazo-Gaztelu (21071939)

CovR levels are decreased in the CovR-T65A strain. by Nicola Horstmann (201711)

Decreased pMHC avidity and CD8β-independence for functional avidity of D^bNPN3A-primed T cells for D^bNP₃₆₆. by Sophie A. Valkenburg (176257)

CFD-DEM Coupling Simulation and Cross-Scale Correlation Analysis of a Liquid-Containing Gas–Solid Spouted Fluidized Bed Reactor by Delong Feng (9075738)

“…When μ > 50 mPa·s, the reverse applies. The macroscale study demonstrates that growing liquid content and viscosity causes a reduction in the bed expansion ratio and the bubble phase volume. …”

Heterozygous deletion of <i>ERG251-A</i> leads to a transcriptional response in filamentation regulation. by Xin Zhou (54275)

Ustekinumab trough concentration are shown by responder status and anti-ustekinumab antibody (A) Patients with negative anti-ustekinumab antibody had significantly higher drug trou... by Hsien-Yi Chiu (799936)

General procedure for the synthesis of B. by Xueqin lu (22250795)

New hydrazonoindolin-2-ones: Synthesis, exploration of the possible anti-proliferative mechanism of action and encapsulation into PLGA microspheres by Mohamed I. Attia (2392672)

“…It increased caspase 3/7 activity by 2.4- and 1.85-fold between 4 and 8 h of treatment, respectively, at 10 μM and it caused a decrease in the percentage of cells in the G1 phase of the cell cycle with a corresponding increase in the S-phase. …”