RI-OR2-TAT reduces the brain load of microglia and oxidative damage and stimulates neurogenesis in APP/PS1 transgenic mice. by Vadivel Parthsarathy (285723)

“…<p>Representative images of activated microglia in the cortical region of APP/PS1 mouse brains as shown by Iba1 immunostaining in animals treated with (<b>A</b>) 0.9% saline or (<b>B</b>) 100 nmol/kg RI-OR2-TAT in 0.9% saline; (<b>C</b>) quantitative analysis shows a decrease in mean microglial load in APP/PS1 mice treated with RI-OR2-TAT; detection of 8 oxo-guanine in the brains of animals treated with (<b>D</b>) 0.9% saline or (<b>E</b>) 100 nmol/kg RI-OR2-TAT; (<b>F</b>) quantitative analysis shows a decrease in mean 8 oxo-guanine staining in APP/PS1 mice treated with RI-OR2-TAT; detection of immature neurons as stained for doublecortin in the dentate gyrus of APP/PS1 mice treated with (<b>G</b>) 0.9% saline or (<b>H</b>) 100 nmol/kg RI-OR2-TAT; (<b>I</b>) quantitative analysis shows an increase in mean doublecortin staining in APP/PS1 mice treated with RI-OR2-TAT. …”

Timeline of the cognitive reappraisal task. by Jae-Hwan Kang (662310)

“…After a 200 ms blank period, a 4000 ms visual emotional stimulus appeared for the cognitive reappraisal task. …”

Image_4_The noise is the signal: spatio-temporal variability of production and productivity in high elevation meadows in the Sierra Nevada mountain range of North America.jpeg by Rob Klinger (2917100)

“…We evaluated spatio-temporal dynamics in production and productivity in meadows within the Sierra Nevada mountain range of North America by: (1) compiling Landsat satellite data for the Normalized Difference Vegetation Index (NDVI) across a 37-year period (1985–2021) for 8,095 meadows >2,500 m elevation; then, (2) used state-space models, changepoint analysis, geographically-weighted regression (GWR), and distance-decay analysis (DDA) to: (a) identify meadows with decreasing, increasing or no trends for NDVI; (b) detect meadows with abrupt changes (changepoints) in NDVI; and (c) evaluate variation along gradients of latitude, longitude, and elevation for eight indices of temporal dynamics in annual production (mean growing season NDVI; MGS) and productivity (rate of spring greenup; RSP). …”

Image_1_The noise is the signal: spatio-temporal variability of production and productivity in high elevation meadows in the Sierra Nevada mountain range of North America.jpeg by Rob Klinger (2917100)

“…We evaluated spatio-temporal dynamics in production and productivity in meadows within the Sierra Nevada mountain range of North America by: (1) compiling Landsat satellite data for the Normalized Difference Vegetation Index (NDVI) across a 37-year period (1985–2021) for 8,095 meadows >2,500 m elevation; then, (2) used state-space models, changepoint analysis, geographically-weighted regression (GWR), and distance-decay analysis (DDA) to: (a) identify meadows with decreasing, increasing or no trends for NDVI; (b) detect meadows with abrupt changes (changepoints) in NDVI; and (c) evaluate variation along gradients of latitude, longitude, and elevation for eight indices of temporal dynamics in annual production (mean growing season NDVI; MGS) and productivity (rate of spring greenup; RSP). …”

Image_3_The noise is the signal: spatio-temporal variability of production and productivity in high elevation meadows in the Sierra Nevada mountain range of North America.jpeg by Rob Klinger (2917100)

“…We evaluated spatio-temporal dynamics in production and productivity in meadows within the Sierra Nevada mountain range of North America by: (1) compiling Landsat satellite data for the Normalized Difference Vegetation Index (NDVI) across a 37-year period (1985–2021) for 8,095 meadows >2,500 m elevation; then, (2) used state-space models, changepoint analysis, geographically-weighted regression (GWR), and distance-decay analysis (DDA) to: (a) identify meadows with decreasing, increasing or no trends for NDVI; (b) detect meadows with abrupt changes (changepoints) in NDVI; and (c) evaluate variation along gradients of latitude, longitude, and elevation for eight indices of temporal dynamics in annual production (mean growing season NDVI; MGS) and productivity (rate of spring greenup; RSP). …”

Image_2_The noise is the signal: spatio-temporal variability of production and productivity in high elevation meadows in the Sierra Nevada mountain range of North America.jpeg by Rob Klinger (2917100)

“…We evaluated spatio-temporal dynamics in production and productivity in meadows within the Sierra Nevada mountain range of North America by: (1) compiling Landsat satellite data for the Normalized Difference Vegetation Index (NDVI) across a 37-year period (1985–2021) for 8,095 meadows >2,500 m elevation; then, (2) used state-space models, changepoint analysis, geographically-weighted regression (GWR), and distance-decay analysis (DDA) to: (a) identify meadows with decreasing, increasing or no trends for NDVI; (b) detect meadows with abrupt changes (changepoints) in NDVI; and (c) evaluate variation along gradients of latitude, longitude, and elevation for eight indices of temporal dynamics in annual production (mean growing season NDVI; MGS) and productivity (rate of spring greenup; RSP). …”

Average relative abundance of the 6 main taxa in undiluted saliva and dilutions 1 to 3 (10⁷ to 10⁵ bacteria per ml, respectively). by Giske Biesbroek (104538)

“…We used ANOVA statistics to test for significant differences. Dilution 3 shows a significant increase in Proteobacteria (p<0.001, mean 26,11% and 3.6%, SD 17.5 and 2.5% respectively) and a significant decrease in Bacteroidetes (p<0.001, mean 18.99% and 43.1% respectively) compared to the undiluted saliva samples. …”

Tonic nM DA stabilizes the timing of LP activity over the short term. by Wulf-Dieter C. Krenz (693267)

“…<p><b>(A) Pyloric output is altered by 1mM 4AP</b>. Representative experiments showing the motor output at three time points for a preparation continuously superfused with 1mM 4AP (blue) or 1mM 4AP + 5nM DA (green) beginning at t = 0. …”

Overall number of deer paths in burned sites counteracted temporal trends observed in unburned sites. by Aishwarya Subramanian (14930268)

“…<p>Given that our data unexpectedly showed a decrease in the number of paths over time in unburned ‘control’ sites (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0297290#sec008" target="_blank">Discussion</a> for possible mechanisms), the inset shows expected change in path density between burned and unburned sites if wildfire had no influence on land use by deer (i.e., to help the reader develop a null expectation given these unexpected temporal trends). …”

Declining trend of <i>Plasmodium falciparum dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps)</i> mutant alleles after the withdrawal of Sulfadoxine-Pyrimethamine... by Sofonias K. Tessema (802681)

“…The prevalence of mutation in <i>Pfdhfr</i> and <i>Pfdhps</i> genes were evaluated and compared for a total of 159 isolates collected in two different time points, 2005 and 2007/08, from Pawe hospital, in North Western Ethiopia. …”

Expression of Shot^EGC and EB1 in adult <i>Drosophila</i> using the Geneswitch system improve locomotion of aged flies. by Pilar Okenve-Ramos (18150546)

“…Data points are shown as circles and as mean ± SEM; <i>p</i>-values obtained from comparisons of pairs of same genotypes with or without RU-486 via Mann–Whitney test. …”

Temporal Trends in Exposures to Six Phthalates from Biomonitoring Data: Implications for Cumulative Risk by Jeanette M. Reyes (1306353)

“…Over this period, there was a 2.2-fold decrease in the mean HI (0.34 to 0.15) and a 7.2-fold decrease in the percentage of participants with an HI > 1 (5.7% to 0.8%), indicating an overall decrease in combined exposure to these phthalates. …”

Activation of the <i>PC3</i> Transgene Accelerates the Differentiation of 1–5-d-Old Adult-Generated Dentate Gyrus Stem and Progenitor Cells by Stefano Farioli-Vecchioli (256006)

“…</p> <p>(B) The number of putative stem cells (type-1; BrdU/GFAP/nestin-positive) decreased about 50% in mice with activated <i>PC3</i> transgene.…”

Whole mount in situ hybridization (WISH) for <i>atp6v1e1</i> ohnologs in zebrafish embryos. by Lore Pottie (10994479)

“…<p>(A-C) Representative images demonstrating WISH for <i>atp6v1e1a</i> and <i>atp6v1e1b</i> at different developmental time points (24 hpf (n = 7), 48 hpf (n = 7), 72 hpf (n = 7), 120 hpf (n = 7) and 168 hpf (n = 7)). …”

Quantification of Errors in Ordinal Outcome Scales Using Shannon Entropy: Effect on Sample Size Calculations by Pitchaiah Mandava (431210)

“…While using the full range of mRS is conceptually appealing, a gain of information is counter-balanced by a decrease in reliability. …”

Epidemiological aspects of American cutaneous leishmaniasis and phlebotomine sandfly population, in the municipality of Monte Negro, State of Rondônia, Brazil by Carolina Bioni Garcia Teles (6044771)

“…RESULTS: There has been a significant decrease in the incidence of ACL of about 50% over the last ten years in the municipality. …”

Effects of S1P and SPHK I₂ on cellular migration/Scratch wound healing assay. by Sarah E. Nicholas (4353886)

“…(D) Scratch assay quantification of S1P stimulated HCFs showing significant decrease (p ≤ 0.0001) in cell migration distance at 24 and 48 hour time points compared to controls (A). …”

Feasibility of CT radiomics to predict treatment response of individual liver metastases in esophagogastric cancer patients by Remy Klaassen (3903154)

Analysis of egress, invasion, and motility in parental and mutant lines. by Shaojun Long (4007162)

“…-IAA or the TIR1 parental line, **, <i>P</i> ≤ 0.0001, the CaM3-AID line showed a significant decrease in twirling and increase in circling when grown in +IAA <i>vs</i>. …”

Individual recording analysis. by Sonya Marshall-Gradisnik (3525122)

“…Baseline = blue dash-lines; PregS baseline = green dash-lines. (A) Baseline; (B) PregS points; (C) PregS baseline; (D) Ononetin points. …”