ACβ and PKA are both essential for parasite proliferation. by Avnish Patel (6393182)

“…Double-headed arrows represent the regions amplified by PCR in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3000264#pbio.3000264.s004" target="_blank">S4C Fig</a>. …”

Data_Sheet_1_Longitudinal Associations Between Household Solid Fuel Use and Handgrip Strength in Middle-Aged and Older Chinese Individuals: The China Health and Retirement Longitud... by Yashu Liu (506892)

“…</p>Results<p>The study included 9,382 participants during a 4-year follow-up. The participants who used solid fuel for cooking had more decreases of HGS than those who used clean fuel (P < 0.0001). …”

Western blot analysis of heme oxygenase-1 (HO-1), NF-κB p65, ICAM-1 and PECAM-1 in the pancreas. by Fajing Yang (635723)

“…<p><b>A)</b> Representative photographs of HO-1 protein levels in the pancreas in the three groups. …”

Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis by Lorena Fernandez-Mosquera (5077820)

“…MCOLN1 is regulated by phosphoinositide kinase PIKFYVE and its product PtdIns(3,5)P₂, which is also decreased in RC-deficiency. Notably, reactivation of AMPK, in a PIKFYVE-dependent manner, or of MCOLN1 in RC-deficient cells, restores lysosomal hydrolytic capacity. …”

Influence of Substrates Present at the Liposomal Interior on Nucleotide Import by Oliver Trentmann (78814)

“…<p>ATP import (A) and ADP import (B) into liposomes loaded with decreasing internal ADP concentrations in absence of additional nucleotides (white bars) and in presence of GTP (light gray bars) or ATP (dark gray bars) was measured. …”

Validation of E. coli Signaling Network Model by Burton W Andrews (274358)

“…For comparison with experimental data, activity from the model is converted to the probability of CCW flagella rotation by means of a Hill function (<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.0020154#s4" target="_blank">Materials and Methods</a>). …”

Age-Related Changes following In Vitro Stimulation with <i>Rhodococcus equi</i> of Peripheral Blood Leukocytes from Neonatal Foals by Priyanka Kachroo (107357)

“…We found induction of genes critical for host immunity against pathogens (MHC class II) only at the later time-points (compared to birth). While it appears that foals up to 8-weeks of age are able to initiate a protective inflammatory response against the bacteria, relatively decreased expression of various other immune-related genes points toward inherent diminished immune responses closer to birth. …”

Data Sheet 1_Pediatric bacterial meningitis in southern China: analysis of 838 cases.docx by Lianfeng Chen (11537137)

“…Moreover, 92.0% of the patients were graded five Glasgow outcome scale (GOS) points at discharge. Differences in symptoms, pathogens, CSF results, brain MRI, and GOS points were observed across age groups (neonate [29 days, 12 months) and aged ≥12 months). …”

Asymmetric cell divisions can induce large cell-to-cell variability in mtDNA quality. by Robert C. Glastad (10692277)

“…The three columns for each panel give decreasing network heterogeneity, expressed via different seed numbers, 4, 16 and 64 (more seed points give a more homogeneous network). …”

Effect of PACAP on NPCs. by Johanna Mäkelä (223358)

“…<p>NPCs were treated for 24 h with 100 ng/ml IFNγ alone or in conjunction with 100 ng/ml PACAP. (<b>A</b>) Immunoblot. Cells were treated for 2 h. …”

Giant Cell Area, Number of Nuclei and Infection Tests of γ-Tubulin Mutants Compared to Wild-Type. by Mohamed Youssef Banora (194398)

“…Data shown represent means±SD from at least two experiments in which a minimum of 60 seedlings of each line were evaluated for nematode infection. …”

Effect of ST6GAL1-activated PI3K/Akt signaling pathway on the expression of P-gp and MRP1. by Hongye Ma (424073)

“…<p>(A) The main molecules of PI3K/Akt pathway were repressed at protein levels with ST6GAL1 shRNA transfection in K562/ADR cells. …”

Shortened and disorganized growth plate in mice with disrupted BMP signaling. by Bettina Keller (231677)

“…<p>(A–C) Growth plate sections of long bones of P1 and (D–F) eight weeks old mice stained with Hematoxylin and Eosin. …”

Effect of TCERG1 on staurosporine-mediated apoptosis involves changes in mitochondrial membrane permeabilization and in the emergence of the active form of Bak. by Marta Montes (812749)

“…<p>(A) TCERG1 knockdown decreases the mitochondrial membrane potential dissipation caused by staurosporine. …”

HO-1 induction increases HO-1, AKT and GSK3β expression in diabetic hearts. by Yossi Issan (540887)

“…<p>A:CoPP treatment significantly increased HO-1 expression levels (Means ± SD, n = 5. …”

Dysregulation of Autophagy Contributes to Anal Carcinogenesis by Evie H. Carchman (3195855)

“…These observations are consistent with autophagy being inhibited at a later stage in the autophagic process. In contrast, in high-grade dysplasia and SCC in the DMBA-treated K14E6/E7 mice, there were decreased levels of p62 with a continued increase in punctate LC3β expression by IF, while autophagolysosomes were seen on EM, consistent with the process of autophagy proceeded to completion. …”

iGP-1 selectively inhibits mitochondrial oxidation of glycerol phosphate. by Adam L. Orr (526725)

“…Data are normalized means ± S.E. (n = 4 for mGPDH, n = 3 for all other sites). …”

DataSheet_1_Dietary disodium fumarate supplementation alleviates subacute ruminal acidosis (SARA)-induced liver damage by inhibiting pyroptosis via mitophagy-NLRP3 inflammasome pat... by Hongzhu Zhang (15650402)

“…The results showed that feeding a high-concentrate diet induced decreased rumen fluid pH and increased ruminal LPS. …”

Root Exudation of Phytochemicals in Arabidopsis Follows Specific Patterns That Are Developmentally Programmed and Correlate with Soil Microbial Functions by Jacqueline M. Chaparro (130585)

“…Cumulative secretion levels of sugars and sugar alcohols were higher in early time points and decreased through development. In contrast, the cumulative secretion levels of amino acids and phenolics increased over time. …”

Reduced Photoreceptor Heterogeneity Packing Index (HPi) in an Eye with Capillary Non-Perfusion Contiguous with the Foveal Avascular Zone (FAZ). by Peter L. Nesper (3625847)

“…(E) Spectral-domain optical coherence tomography (SD-OCT) registered to the IR image showing the retinal area covered by the AOSLO montage. B-scan shows focal points where inner segment / outer segment junction is interrupted with decreased intensity of the outer segment / retinal pigment epithelium junction. …”