Drugs altering the synchrony index modulate the function of MIN6 cells. by Sabine Bavamian (148288)

“…All drugs, but glibenclamide and quinine, also increased to control levels their fractional insulin release (<i>expressed as percentage of insulin content</i>), when challenged with a high glucose level (<i>right panel</i>). (<i>B</i>) The insulin content of MIN6 cells was reduced by all drugs decreasing the synchrony index and by glibenclamide. …”

The actin cytoskeleton in the basilar epithelium of the organ of Corti. by Guang-Jie Zhu (327772)

“…<p>(A) In the cochleae of MLCK^IKO mice, staining with phalloidin reveals decreased F-actin formation in the cytoplasm and cell membrane of IHCs, whereas its expression in pillar cells (PCs) and OHCs remains strong in comparison with that of CTR mice. …”

Comparison of neurogenic activity between levodopa and PPX in MTPT-treated PD animals. by Jin Young Shin (116728)

“…<p>The immunohistochemistry analysis revealed that the number of BrdU-positive cells decreased significantly in MPTP-treated mice compared to control mice, whereas levodopa or PPX treatment increased BrdU-positive cells in MPTP-treated mice compared to MPTP-only treated mice (A). …”

Fibrosis-related genes after eight weeks of MCD diet. by Daniel Heinrichs (323862)

“…However, mRNA expression of <i>TGF-β1</i> does not vary in <i>CCL3^−/−</i> mice (<b>A</b>). <i>α-SMA</i> expression is significantly decreased in <i>CCL3^−/−</i> mice after MCD diet. …”

Environmental enrichment and visceral inflammation modify stress-induced c-Fos expression in the hippocampus. by Florian Reichmann (288321)

“…<p>Environmental enrichment increases stress-induced expression of c-Fos in (A) the granular cell layer of the dentate gyrus, decreases c-Fos expression in (B) the hippocampal CA1 region, but does not alter c-Fos levels in (C) the hippocampal CA3 region. …”

Metastin and GPR54 protein expressions in early-onset and late-onset preeclamptic placenta. by Chong Qiao (299588)

“…Data represent means±SD after normalization to β-actin. *P<0.05, significantly decreased/increased compared with the respective control.…”

Cell viability of TGCs. by Hiromu Morimoto (11133531)

“…The percentages of dead TGCs decreased significantly in a P₄-dose-dependent manner. …”

Environmental enrichment and visceral inflammation modify stress-induced c-Fos expression in the medial prefrontal cortex and the hypothalamus. by Florian Reichmann (288321)

“…<p>Environmental enrichment decreases stress-induced c-Fos expression in (C) the infralimbic cortex but does not alter stress-induced c-Fos levels in (B) the cingulate cortex and (A) paraventricular nucleus of the hypothalamus. …”

Extracting T cell retention kinetics from two-photon data. by Johannes Textor (610955)

“…Moreover, persistence decreases (higher turning angles). <b>(C)</b> Aggregate results of the gating approach shown in (B) applied to 32 two-photon videos from 10 independent experiments <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1003752#pcbi.1003752-Henrickson1" target="_blank">[25]</a>. …”

PBMC activation and <i>ex vivo</i> cytokine/chemokine expression during seasonal influenza infection. by Nelson Lee (118132)

“…<p>PBMC actively expressed IL-6, (CXCL8/IL-8), CCL2/MCP-1, CXCL10/IP-10, and CXCL9/MIG during acute influenza infection; upon illness recovery, cytokine production decreased, and there was a corresponding increase in cellular responsiveness to stimuli. …”

Human papillomavirus type 16 E6 and NFX1-123 mislocalize immune signaling proteins and downregulate immune gene expression in keratinocytes by Justine Levan (4579156)

“…Knock down of NFX1-123 in 16E6 HFKs resulted in a derepression of innate immune genes, pointing to the requirement of NFX1-123 for immune regulation in the context of 16E6. …”

Ratio of oligomers, dimers, and monomers of Pmr_nt₆₁ and its variants. by Chiho Suzuki (377633)

“…Pmr_nt₆₁ variants are indicated, such as “E6A” for Pmr_nt₆₁-E6A. Data are expressed as means ± standard deviation from three (for Pmr_nt₆₁ variants) or five (for native Pmr_nt₆₁) independent experiments. …”

LncRNA SCARNA8 promotes atherosclerotic plaque instability by inhibiting macrophage efferocytosis by Xiaoliang Yin (13301607)

“…In addition, knockdown of lncRNA SCARNA8 improved the stability of atherosclerotic plaques by promoting cellular burial of Raw264.7 cells. LncRNA SCARNA8 is a key regulator of plaque vulnerability, and targeting lncRNA SCARNA8 May provide a novel means for the prevention and treatment of AS.…”

Analysis of MAPK and CREB activating phosphorylation. by Barbara Bellei (177809)

“…(C) The same immunoreactivities as in (A) were also tested following 24 h of mitogenic factors starvation (M254 medium containing 0.5% FBS) (VHM n = 8; NHM n = 8); NHM and VHM significantly decreased the level of CREB and MAPK phosphorylation. …”

Integrative Transcriptome Profiling of Cognitive Aging and Its Preservation through Ser/Thr Protein Phosphatase Regulation by C. Sehwan Park (759313)

“…Together, this study provides a comprehensive map of the transcriptome and proteome in the aging brain, and elucidates endogenous protein phosphatase-1 inhibition as a potential means through which environmental enrichment may ameliorate age-related cognitive deficits.…”

Effect of ST8SiaII inhibition on tumour cell migration. by Yousef M. J. Al-Saraireh (443980)

“…CMP treatment at all concentrations decreased the migration capacity of polySia-expressing SH-SY5Y and C6-STX cells in a concentration dependent manner. …”

ION ligation induces mechanical hyperalgesia. by Karine Thibault (533495)

“…<p>A: Schematic representation of the experimental paradigm. …”

Rabbit ATG and alemtuzumab increase FasL, TNFα and IFNγ mRNA in NK cells. by Diana Stauch (266579)

“…<p>(A) IL-2 (200 IU/ml) pre-activated NK cells cultured in the presence of rATG were analyzed for FasL, TNFα and IFNγ mRNA after 1, 2, 3 and 6 hours of co-culture. rATG induced a rapid and dose-dependent induction of FasL, TNFα and IFNγ mRNA in NK cells which decreased after 6 hours of co-incubation. …”

miR-493 expression levels are frequently downregulated in human lung cancer and associated with Prognosis. by Yixue Gu (294945)

“…A expression value <1 indicates that the miR-493 levels is decreased in tumors. …”

Alterations in bacterial and fungal community structures during RS-EX treatment revealed by alterations in phosphatidylethanolamine (PE) molecular species composition. by Meike Siebers (4338715)

“…<p>Changes in PE molecular species in A. control and B. RS-EX treated soil samples were measured by Q-TOF mass spectrometry. …”